sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pvk | P45 | Casein kinase II subunit alpha | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2pvk | P45 | Casein kinase II subunit alpha | 2.7.11.1 | 1.000 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.652 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.634 | |
| 2pvj | P44 | Casein kinase II subunit alpha | 2.7.11.1 | 0.617 | |
| 2pvh | P19 | Casein kinase II subunit alpha | 2.7.11.1 | 0.595 | |
| 2pvm | P29 | Casein kinase II subunit alpha | 2.7.11.1 | 0.579 | |
| 1daw | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.555 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.546 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.519 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.506 | |
| 4dgm | AGI | Casein kinase II subunit alpha | 2.7.11.1 | 0.504 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.501 | |
| 2bun | FAD | AppA protein | / | 0.500 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.500 | |
| 3at3 | ATK | Casein kinase II subunit alpha | 2.7.11.1 | 0.498 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.496 | |
| 4kxn | 6K6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.496 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.495 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.491 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.491 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.491 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.490 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.490 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.489 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.488 | |
| 1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.487 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 2j9m | PY8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.487 | |
| 3lpb | NVB | Tyrosine-protein kinase JAK2 | / | 0.486 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.485 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 4ijp | 1EH | Serine/threonine-protein kinase PRP4 homolog | 2.7.11.1 | 0.484 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.483 | |
| 2ejz | SAH | Diphthine synthase | / | 0.481 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.480 | |
| 4xwt | U5P | Ribonuclease J | / | 0.479 | |
| 3qwi | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.478 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.477 | |
| 3ofm | 4B0 | Casein kinase II subunit alpha' | 2.7.11.1 | 0.477 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.476 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.475 | |
| 3t8v | BTJ | M1 family aminopeptidase | 3.4.11 | 0.475 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.475 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.474 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.474 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.474 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.473 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.473 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.473 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.472 | |
| 3rvg | 17P | Tyrosine-protein kinase JAK2 | / | 0.471 | |
| 4f08 | 1RS | Tyrosine-protein kinase JAK2 | / | 0.471 | |
| 2xs0 | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.470 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.470 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.469 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.469 | |
| 3a3b | RBF | Lumazine protein | / | 0.467 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.467 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.467 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.467 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.467 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.466 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.466 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.466 | |
| 4b4d | FAD | Ferredoxin-NADP reductase | / | 0.466 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.465 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 2cdu | ADP | NADH oxidase | / | 0.465 | |
| 2gst | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.465 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.465 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.465 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.465 | |
| 4ix5 | ANP | Uncharacterized protein | / | 0.465 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.465 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.464 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.464 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.464 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.464 | |
| 3u9e | COA | Lmo1369 protein | / | 0.464 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.464 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.463 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.463 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.463 | |
| 2xb5 | I7T | Tetracycline repressor protein class D | / | 0.463 | |
| 3qx2 | X63 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.463 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.462 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.462 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.462 | |
| 3q9z | TXQ | Casein kinase II subunit alpha | 2.7.11.1 | 0.462 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.462 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.462 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.461 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.461 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.461 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.461 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.461 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.460 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.460 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.460 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.459 | |
| 1j21 | ATP | Argininosuccinate synthase | / | 0.459 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.459 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.459 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.459 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.459 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.459 | |
| 1gqt | ACP | Ribokinase | / | 0.458 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.458 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.458 | |
| 2np8 | CC3 | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 3csc | ACO | Citrate synthase, mitochondrial | 2.3.3.1 | 0.458 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.458 | |
| 4e2b | FMN | Dehydrogenase | / | 0.458 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.458 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.457 | |
| 3gob | HXX | DdmC | / | 0.457 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.457 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.457 | |
| 4e20 | 0MY | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.457 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4g73 | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.457 | |
| 5dnr | ATP | Aurora kinase A | 2.7.11.1 | 0.457 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.456 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.456 | |
| 1jnk | ANP | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.456 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.456 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2eka | SAH | Diphthine synthase | / | 0.456 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.456 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.456 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.456 | |
| 4dij | BLF | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.456 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.456 | |
| 4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.456 | |
| 1dv2 | ATP | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.455 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.455 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.455 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.455 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.455 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.454 | |
| 1ppj | ANY | Cytochrome b | / | 0.454 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.454 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.454 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.454 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.454 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.454 | |
| 3uim | ANP | BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 | 2.7.10.1 | 0.454 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.454 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 4ibm | IR1 | Insulin receptor | 2.7.10.1 | 0.454 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.453 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.453 | |
| 2ele | SAH | Diphthine synthase | / | 0.453 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2yyy | NAP | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.59 | 0.453 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.453 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.453 | |
| 3zmm | F9J | Tyrosine-protein kinase JAK2 | / | 0.453 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.453 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.453 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.453 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.452 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 1zdw | FLV | Prenyltransferase | / | 0.452 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.452 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.452 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3f7z | 34O | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.452 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.452 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.452 | |
| 1dfo | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.451 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1r2j | FAD | FkbI | / | 0.451 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.451 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.451 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.451 | |
| 2owk | SAH | Diphthine synthase | / | 0.451 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.451 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.451 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.451 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.451 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.451 | |
| 4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.451 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.451 | |
| 1kqn | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.450 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 2ehl | SAH | Diphthine synthase | / | 0.450 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.450 | |
| 2pzi | AXX | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.450 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.450 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.450 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.450 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.450 | |
| 3suf | SUE | Polyprotein | / | 0.450 | |
| 3tqc | ADP | Pantothenate kinase | / | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.450 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.450 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.450 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.450 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.450 | |
| 4qny | ANP | Mitogen activated protein kinase, putative | / | 0.450 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.449 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.449 | |
| 1ol5 | ADP | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 2pcg | SAH | Diphthine synthase | / | 0.449 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.449 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.449 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 3i81 | EBI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.449 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.449 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 4fdp | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.449 | |
| 4iva | 1J5 | Tyrosine-protein kinase JAK2 | / | 0.449 | |
| 4j95 | ACP | Fibroblast growth factor receptor 2 | / | 0.449 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.449 | |
| 4kqq | VPP | Peptidoglycan D,D-transpeptidase FtsI | / | 0.449 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.449 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.449 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.449 | |
| 1q8y | ADP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.448 | |
| 1s60 | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.448 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.448 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.448 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.448 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.448 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.448 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.448 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.448 | |
| 4ww0 | ADP | ATP-dependent zinc metalloprotease FtsH | / | 0.448 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.448 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 5hyn | SAH | Histone-lysine N-methyltransferase EZH2 | 2.1.1.43 | 0.448 | |
| 6cts | CIC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.448 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.447 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.447 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.447 | |
| 2emu | SAH | Diphthine synthase | / | 0.447 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.447 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.447 | |
| 3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.447 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.447 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.447 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.447 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.447 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.447 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.446 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.446 | |
| 1pyx | ANP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1u5r | ATP | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.446 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.446 | |
| 2czf | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.446 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 3bej | MUF | Bile acid receptor | / | 0.446 | |
| 3l1s | Z92 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.446 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.446 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.446 | |
| 4gap | NAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.446 | |
| 4jay | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.446 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.446 | |
| 1i6x | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.445 | |
| 1ig1 | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.445 | |
| 1m0b | 0ZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1m4d | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.445 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 2e07 | SAH | Diphthine synthase | / | 0.445 | |
| 2eva | ADN | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.445 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.445 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3uqd | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.445 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.445 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.445 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.445 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.444 | |
| 1g9d | BAB | Botulinum neurotoxin type B | 3.4.24.69 | 0.444 | |
| 1lik | ADN | Adenosine kinase | 2.7.1.20 | 0.444 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.444 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.444 | |
| 2w6n | OA2 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.444 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.444 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.444 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.444 | |
| 4lsl | 1YQ | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.444 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.443 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.443 | |
| 1osv | CHC | Bile acid receptor | / | 0.443 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.443 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.443 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.443 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.443 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 2w1g | L0G | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.443 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3juh | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3ort | AGS | Serine/threonine protein kinase | / | 0.443 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 4cgp | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.443 | |
| 4ful | 0VU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4hvg | 19Q | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.443 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.443 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.443 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.443 | |
| 6gsw | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.443 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.442 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2p2x | SAH | Diphthine synthase | / | 0.442 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.442 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.442 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 4die | C5P | Cytidylate kinase | / | 0.442 | |
| 4en4 | ATP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.442 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.442 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.441 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.441 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 1ork | ATC | Tetracycline repressor protein class D | / | 0.441 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.441 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2gqt | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.441 | |
| 2i0a | MUI | Protease | / | 0.441 | |
| 2izu | P01 | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.441 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.441 | |
| 2pvy | ACP | Fibroblast growth factor receptor 2 | / | 0.441 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.441 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.441 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.441 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.441 | |
| 4c61 | LMM | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4dn5 | AGS | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.441 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.441 | |
| 4hvi | 19S | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.441 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.441 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.441 | |
| 5fkl | TDC | Tetracycline repressor protein class D | / | 0.441 | |
| 1c7o | PPG | Hemolysin | / | 0.440 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.440 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.440 | |
| 1zp3 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.440 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 2wtk | ANP | STE20-related kinase adapter protein alpha | / | 0.440 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.440 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.440 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.440 | |
| 3r7u | X96 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.440 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3w8q | AGS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.440 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.440 | |
| 4f9c | 0SX | Cell division cycle 7-related protein kinase | 2.7.11.1 | 0.440 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.440 | |
| 4l9k | EHF | Serum albumin | / | 0.440 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.440 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 |