sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 1.000 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.607 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.585 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.553 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.549 | |
| 3igo | ANP | Calmodulin-domain protein kinase 1, putative | / | 0.468 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.457 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.457 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.456 | |
| 3eej | 53R | Uncharacterized protein | / | 0.453 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.449 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4j95 | ACP | Fibroblast growth factor receptor 2 | / | 0.447 | |
| 4qml | ANP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.445 | |
| 2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.444 | |
| 2v7a | 627 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.444 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3a7h | ATP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.442 | |
| 5auw | QUE | Death-associated protein kinase 1 | 2.7.11.1 | 0.442 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2cke | IQU | Death-associated protein kinase 2 | / | 0.441 | |
| 3eem | 53V | Uncharacterized protein | / | 0.441 | |
| 3ort | AGS | Serine/threonine protein kinase | / | 0.441 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.441 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 1wvx | BD4 | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3qly | 55V | Uncharacterized protein | / | 0.440 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.440 |