sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2puf | GUN | HTH-type transcriptional repressor PurR |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2puf | GUN | HTH-type transcriptional repressor PurR | / | 1.000 | |
| 2puc | GUN | HTH-type transcriptional repressor PurR | / | 0.544 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.505 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.494 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.490 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.490 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.478 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.477 | |
| 4fw0 | 5KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.477 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.477 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.475 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.473 | |
| 4zvm | DM2 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.473 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1mq0 | BRD | Cytidine deaminase | 3.5.4.5 | 0.471 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.471 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.471 | |
| 1f28 | F89 | Thymidylate synthase | 2.1.1.45 | 0.470 | |
| 1g28 | FMN | PHY3 | / | 0.470 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.470 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.469 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 3nhw | ZXZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.468 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.468 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.468 | |
| 4gqi | M49 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.468 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 4zvn | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.467 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4uga | Q05 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.466 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.465 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.465 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.465 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.464 | |
| 2fai | 459 | Estrogen receptor | / | 0.464 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.464 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.463 | |
| 1uwz | THU | Cytidine deaminase | 3.5.4.5 | 0.463 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 2v95 | HCY | Corticosteroid-binding globulin | / | 0.463 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 1dib | L34 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.462 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.462 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4dju | 0KK | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4k5f | Q14 | Nitric oxide synthase, brain | 1.14.13.39 | 0.462 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.461 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 4fvz | 4KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.461 | |
| 3n5y | XFL | Nitric oxide synthase, brain | 1.14.13.39 | 0.460 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4h6p | FMN | Chromate reductase | / | 0.460 | |
| 4hsh | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.460 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.459 | |
| 3dqr | JI2 | Nitric oxide synthase, brain | 1.14.13.39 | 0.459 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.458 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3gts | D3M | DdmC | / | 0.458 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.458 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.458 | |
| 5ahk | FAD | Acetolactate synthase II, large subunit | / | 0.458 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3uxe | 465 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.457 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.457 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.457 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.456 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
| 3d5w | ADP | Serine/threonine-protein kinase PLK | / | 0.456 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3nhf | VVV | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.456 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.456 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.456 | |
| 3ufs | HW6 | Nitric oxide synthase, brain | 1.14.13.39 | 0.456 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4djw | 0KP | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.456 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.456 | |
| 1til | ATP | Anti-sigma F factor | / | 0.455 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.455 | |
| 4l8u | 9AZ | Serum albumin | / | 0.455 | |
| 1jtk | THU | Cytidine deaminase | 3.5.4.5 | 0.454 | |
| 2p2b | COA | Acetyl-coenzyme A synthetase | / | 0.454 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.454 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.454 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.454 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.454 | |
| 3up3 | XCA | aceDAF-12 | / | 0.454 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.454 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.453 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.453 | |
| 2zi5 | 3L1 | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.453 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.453 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.452 | |
| 3g5m | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.452 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.452 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.452 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4mub | OAQ | Sulfotransferase oxamniquine resistance protein | / | 0.452 | |
| 2qmy | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.451 | |
| 2v34 | CTN | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.451 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.451 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.451 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.451 | |
| 1djq | FMN | Trimethylamine dehydrogenase | 1.5.8.2 | 0.450 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.450 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 3dle | GFA | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 3jq3 | ADP | Lombricine kinase | / | 0.450 | |
| 3qfv | NM7 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.450 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.450 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.450 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.449 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.449 | |
| 2rgx | AP5 | Adenylate kinase | / | 0.449 | |
| 2vag | V25 | Dual specificity protein kinase CLK1 | 2.7.12.1 | 0.449 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.449 | |
| 3e7t | B14 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.449 | |
| 3zkn | WZV | Beta-secretase 2 | 3.4.23.45 | 0.449 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.449 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.448 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.448 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.448 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4jsh | Q15 | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.447 | |
| 5erm | 210 | Fusicoccadiene synthase | 4.2.3.43 | 0.447 | |
| 2bzs | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 2hq9 | FAD | Mll6688 protein | / | 0.446 | |
| 2hru | ADP | Phosphoribosylformylglycinamidine synthase subunit PurL | / | 0.446 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.446 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.446 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.446 | |
| 4imu | 1ET | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.446 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.445 | |
| 1xi2 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.445 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 3eah | 327 | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.445 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.445 | |
| 3png | 8CX | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.445 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.445 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.444 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3n65 | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.444 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.444 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.443 | |
| 1syn | F89 | Thymidylate synthase | / | 0.443 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1uxv | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.443 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.443 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.443 | |
| 2v18 | FMN | Dodecin | / | 0.443 | |
| 3nhk | VAP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4gqe | 6KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 4jpe | 1M7 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.443 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1zzr | DP9 | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3ebf | 332 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.442 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.442 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 4gcx | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.442 | |
| 4tv3 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.442 | |
| 5fbh | TCR | Extracellular calcium-sensing receptor | / | 0.442 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.442 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.442 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.441 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.441 | |
| 2ejz | SAH | Diphthine synthase | / | 0.441 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.441 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3cqu | CQU | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.441 | |
| 3mcv | MCV | Pteridine reductase | / | 0.441 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.441 | |
| 3owx | XRA | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.441 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.441 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.441 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.441 | |
| 4gr9 | 372 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 4hqv | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 1tsd | F89 | Thymidylate synthase | / | 0.440 | |
| 1zzq | DP9 | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.440 | |
| 2qjp | ANJ | Cytochrome b | / | 0.440 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.440 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.440 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.440 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4jsf | QJ4 | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 4n1g | CEI | Obelin | / | 0.440 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.440 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.440 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 |