sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2puc | GUN | HTH-type transcriptional repressor PurR |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2puc | GUN | HTH-type transcriptional repressor PurR | / | 1.000 | |
| 1wet | GUN | HTH-type transcriptional repressor PurR | / | 0.547 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.495 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.484 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.476 | |
| 4j7h | TRH | PCZA361.3 | / | 0.471 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.452 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.452 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.450 | |
| 2yye | APC | Selenide, water dikinase | 2.7.9.3 | 0.450 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.449 | |
| 2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.448 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.447 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.446 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4j7g | TRH | PCZA361.3 | / | 0.446 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.446 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 5j60 | FAD | Thioredoxin reductase | / | 0.444 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 |