Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pmoHMDProtein kinase 7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pmoHMDProtein kinase 7/1.000
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.520
2pmlANPUncharacterized protein/0.507
2pmnK51Protein kinase 7/0.506
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.506
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.503
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.503
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.497
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.494
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.487
5e8wSTUTGF-beta receptor type-12.7.11.300.484
3q9xEMOCasein kinase II subunit alpha2.7.11.10.483
4deeADPAurora kinase A2.7.11.10.480
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.480
3be9P04Casein kinase II subunit alpha2.7.11.10.478
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.476
5dr9SKEAurora kinase A2.7.11.10.476
2vu3LZECyclin-dependent kinase 22.7.11.220.474
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.473
1psa0ZLPepsin A3.4.23.10.472
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.472
4hge15VTyrosine-protein kinase JAK2/0.472
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.470
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
1mq4ADPAurora kinase A2.7.11.10.469
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.469
4ix6ADPUncharacterized protein/0.469
1xddAAYIntegrin alpha-L/0.467
2pvnP63Casein kinase II subunit alpha2.7.11.10.467
4jia1K3Tyrosine-protein kinase JAK2/0.467
2pvhP19Casein kinase II subunit alpha2.7.11.10.466
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.465
1m2pHNACasein kinase II subunit alpha2.7.11.10.464
3rak03ZCyclin-dependent kinase 22.7.11.220.464
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.464
2po7CHDFerrochelatase, mitochondrial4.99.1.10.463
3r9dX6BCyclin-dependent kinase 22.7.11.220.463
2w05FRTCyclin-dependent kinase 22.7.11.220.461
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.461
1k6tXN1Gag-Pol polyprotein3.4.23.160.460
1nzdUPGDNA beta-glucosyltransferase/0.460
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.460
3iok1P6Tyrosine-protein kinase JAK2/0.460
3sw418KCyclin-dependent kinase 22.7.11.220.460
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.460
3mtfA3FActivin receptor type-12.7.11.300.459
4gmy0X5Tyrosine-protein kinase JAK2/0.459
4jr7GNPCasein kinase II subunit alpha2.7.11.10.459
2ckeIQUDeath-associated protein kinase 2/0.458
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.458
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.458
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.458
4hvi19STyrosine-protein kinase JAK32.7.10.20.458
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.458
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.457
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.457
2g1s4IGRenin3.4.23.150.456
2vttLZDCyclin-dependent kinase 22.7.11.220.456
2vv9IM9Cyclin-dependent kinase 22.7.11.220.456
3gxlQIGTGF-beta receptor type-12.7.11.300.456
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.456
4bbe3O4Tyrosine-protein kinase JAK2/0.456
4qmpDKISerine/threonine-protein kinase 242.7.11.10.456
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.456
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
3hx4ANPCalmodulin-domain protein kinase 1/0.455
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.455
4wsqKSAAP2-associated protein kinase 12.7.11.10.455
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.454
2cciATPCyclin-dependent kinase 22.7.11.220.454
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.454
3nieANPMitogen-activated protein kinase/0.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.454
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.454
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.454
4o0wADNAurora kinase A2.7.11.10.454
2a0cCK9Cyclin-dependent kinase 22.7.11.220.453
2xa4AZ5Tyrosine-protein kinase JAK2/0.453
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.453
4anmWULCasein kinase II subunit alpha2.7.11.10.453
4aqc88ATyrosine-protein kinase JAK2/0.453
4hgs15GCasein kinase I isoform gamma-32.7.11.10.453
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.452
2h96893Mitogen-activated protein kinase 82.7.11.240.452
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
2uxuNARHTH-type transcriptional regulator TtgR/0.452
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.452
3kvxFMYMitogen-activated protein kinase 102.7.11.240.452
3nwq2NCGag-Pol polyprotein3.4.23.160.452
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.452
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.452
2wotZZGTGF-beta receptor type-12.7.11.300.451
3oqkS52Renin3.4.23.150.451
3rk708ZCyclin-dependent kinase 22.7.11.220.451
4bb3KKAIsopenicillin N synthase1.21.3.10.451
4dymIYZActivin receptor type-12.7.11.300.451
1gii1PUCyclin-dependent kinase 22.7.11.220.450
1me6IVSPlasmepsin-23.4.23.390.450
3lltANPProtein serine/threonine kinase-1/0.450
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.450
4bbfO19Tyrosine-protein kinase JAK2/0.450
4bgg844Activin receptor type-12.7.11.300.450
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.450
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.450
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.449
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2zjwREFCasein kinase II subunit alpha2.7.11.10.449
3pe2E1BCasein kinase II subunit alpha2.7.11.10.449
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.449
4bfvZVVPantothenate kinase2.7.1.330.449
5drdATPAurora kinase A2.7.11.10.449
1c6yMK1Protease/0.448
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.448
2np8CC3Aurora kinase A2.7.11.10.448
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3sw719KCyclin-dependent kinase 22.7.11.220.448
3u9eCOALmo1369 protein/0.448
3w2sW2REpidermal growth factor receptor2.7.10.10.448
4bcmT7ZCyclin-dependent kinase 22.7.11.220.448
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
1k6cMK1Gag-Pol polyprotein3.4.23.160.447
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2iw84SPCyclin-dependent kinase 22.7.11.220.447
3juhANPCasein kinase II subunit alpha2.7.11.10.447
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.447
3w33W19Epidermal growth factor receptor2.7.10.10.447
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.447
4ic7ANPMitogen-activated protein kinase 72.7.11.240.447
4ocvANPAminoglycoside phosphotransferase/0.447
5eoxADPType 4 fimbrial biogenesis protein PilM/0.447
5k2bZMAAdenosine receptor A2a/0.447
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.446
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2ikuLIYRenin3.4.23.150.446
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.446
3zep1NXTyrosine-protein kinase JAK32.7.10.20.446
3zh8C58Protein kinase C iota type2.7.11.130.446
4iarERM5-hydroxytryptamine receptor 1B/0.446
4y93746Tyrosine-protein kinase/0.446
2pvlP55Casein kinase II subunit alpha2.7.11.10.445
2r3lSCWCyclin-dependent kinase 22.7.11.220.445
3bheBZNGag-Pol polyprotein3.4.23.160.445
3gu83GUDeath-associated protein kinase 12.7.11.10.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.445
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.445
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
1aq1STUCyclin-dependent kinase 22.7.11.220.444
1dawANPCasein kinase II subunit alpha2.7.11.10.444
1rdwLARActin, alpha skeletal muscle/0.444
1u4dDBQActivated CDC42 kinase 1/0.444
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.444
2dwbANPAurora kinase A2.7.11.10.444
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.444
2iko7IGRenin3.4.23.150.444
2xikJ60Serine/threonine-protein kinase 252.7.11.10.444
3nynSGVG protein-coupled receptor kinase 62.7.11.160.444
3oroAGSSerine/threonine protein kinase/0.444
3oxv478Gag-Pol polyprotein3.4.23.160.444
4dgo0JWCasein kinase II subunit alpha2.7.11.10.444
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.444
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.444
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.444
5cvfATPCasein kinase II subunit alpha2.7.11.10.444
1k6pXN3Gag-Pol polyprotein3.4.23.160.443
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.443
3ibdCPZCytochrome P450 2B61.14.130.443
3w32W32Epidermal growth factor receptor2.7.10.10.443
4dgnLU2Casein kinase II subunit alpha2.7.11.10.443
1k6vXN2Gag-Pol polyprotein3.4.23.160.442
1sh9RITGag-Pol polyprotein3.4.23.160.442
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.442
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.442
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4ek816KCyclin-dependent kinase 22.7.11.220.442
5e8ySTUTGF-beta receptor type-22.7.11.300.442
1bygSTUTyrosine-protein kinase CSK/0.441
1g1aNADdTDP-glucose 4,6-dehydratase/0.441
1nzfUPGDNA beta-glucosyltransferase/0.441
1p2a5BNCyclin-dependent kinase 22.7.11.220.441
1qrpHH0Pepsin A-43.4.23.10.441
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.441
2fvdLIACyclin-dependent kinase 22.7.11.220.441
2gjlFMNNitronate monooxygenase1.13.12.160.441
2p54735Peroxisome proliferator-activated receptor alpha/0.441
2uxpCLMHTH-type transcriptional regulator TtgR/0.441
3kpkFADSulfide-quinone reductase/0.441
5dnrATPAurora kinase A2.7.11.10.441
1eh4IC1Casein kinase I homolog 12.7.11.10.440
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
3ddpRC8Cyclin-dependent kinase 22.7.11.220.440
3qtuX44Cyclin-dependent kinase 22.7.11.220.440
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4fx360KCyclin-dependent kinase 22.7.11.220.440