scPDB - Distribution of Binding site Similarity values of 2pg2 entry / Site 3

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2pg2	ADP	Kinesin-like protein KIF11

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2pg2	ADP	Kinesin-like protein KIF11	/	1.000
2xae	ADP	Kinesin-like protein KIF11	/	0.630
1yrs	ADP	Kinesin-like protein KIF11	/	0.587
2q2y	ADP	Kinesin-like protein KIF11	/	0.563
2x2r	ADP	Kinesin-like protein KIF11	/	0.559
2g1q	ADP	Kinesin-like protein KIF11	/	0.529
3l9h	ADP	Kinesin-like protein KIF11	/	0.521
3k3b	ADP	Kinesin-like protein KIF11	/	0.517
4zhi	ADP	Kinesin-like protein KIF11	/	0.516
2x7e	ADP	Kinesin-like protein KIF11	/	0.511
2fl2	ADP	Kinesin-like protein KIF11	/	0.509
3hqd	ANP	Kinesin-like protein KIF11	/	0.509
1ii6	ADP	Kinesin-like protein KIF11	/	0.507
2gm1	ADP	Kinesin-like protein KIF11	/	0.501
4feu	537	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.500
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.480
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.475
8cat	NDP	Catalase	1.11.1.6	0.475
2pbw	DOQ	Glutamate receptor ionotropic, kainate 1	/	0.474
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.471
4few	PP2	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.470
4ej7	ATP	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.468
4ap0	ADP	Kinesin-like protein KIF11	/	0.467
1dis	BDM	Dihydrofolate reductase	1.5.1.3	0.465
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.464
7cat	NDP	Catalase	1.11.1.6	0.463
2xtb	KRM	Adenosine kinase, putative	/	0.462
4a51	ADP	Kinesin-like protein KIF11	/	0.462
4j52	1J3	Serine/threonine-protein kinase PLK1	2.7.11.21	0.462
2q2z	ADP	Kinesin-like protein KIF11	/	0.461
3lfc	Z86	Mitogen-activated protein kinase 14	/	0.461
4fev	PP1	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.461
1yho	TRR	Dihydrofolate reductase	1.5.1.3	0.460
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.460
3c0g	3AM	Peripheral plasma membrane protein CASK	2.7.11.1	0.460
3c34	KAI	Glutamate receptor ionotropic, kainate 1	/	0.460
3s41	S41	Glucokinase	2.7.1.2	0.460
4fgh	0U6	Dihydrofolate reductase	1.5.1.3	0.460
2jb4	A14	Isopenicillin N synthase	1.21.3.1	0.459
4ele	31I	Dihydrofolate reductase	/	0.459
3c35	KAI	Glutamate receptor ionotropic, kainate 1	/	0.458
4a4x	JUP	Serine/threonine-protein kinase Nek2	2.7.11.1	0.458
4pl9	ADP	Ethylene receptor 1	/	0.458
1ne6	SP1	cAMP-dependent protein kinase type I-alpha regulatory subunit	/	0.457
3qm4	PN0	Cytochrome P450 2D6	/	0.457
4a1z	ADP	Kinesin-like protein KIF11	/	0.456
5c6c	CMP	cGMP-dependent protein kinase 2	2.7.11.12	0.456
2xkc	4VQ	Serine/threonine-protein kinase Nek2	2.7.11.1	0.455
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.455
2bu9	HFV	Isopenicillin N synthase	1.21.3.1	0.454
2wqo	VGK	Serine/threonine-protein kinase Nek2	2.7.11.1	0.454
3sqw	ANP	ATP-dependent RNA helicase MSS116, mitochondrial	3.6.4.13	0.454
4l8u	9AZ	Serum albumin	/	0.454
1jxz	BCA	4-chlorobenzoyl coenzyme A dehalogenase	3.8.1.7	0.453
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.453
2xk4	OL2	Serine/threonine-protein kinase Nek2	2.7.11.1	0.453
4j53	1J4	Serine/threonine-protein kinase PLK1	2.7.11.21	0.453
5d7q	4I5	NAD-dependent protein deacetylase sirtuin-2	3.5.1	0.453
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.452
1qjf	ACS	Isopenicillin N synthase	1.21.3.1	0.452
2xke	WI2	Serine/threonine-protein kinase Nek2	2.7.11.1	0.452
3cth	319	Hepatocyte growth factor receptor	2.7.10.1	0.452
3jwc	EKB	Dihydrofolate reductase	/	0.452
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.452
4dhy	S41	Glucokinase	2.7.1.2	0.451
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.451
4elg	52J	Dihydrofolate reductase	/	0.451
4u0m	GTP	Cyclic GMP-AMP synthase	/	0.451
5uvi	ZMA	Adenosine receptor A2a	/	0.451
1s7g	NAD	NAD-dependent protein deacylase 2	/	0.450
2hm9	TRR	Dihydrofolate reductase	1.5.1.3	0.450
2xk6	EQH	Serine/threonine-protein kinase Nek2	2.7.11.1	0.450
2xkd	T3M	Serine/threonine-protein kinase Nek2	2.7.11.1	0.450
4gxs	0YS	Glutamate receptor 2	/	0.450
4lt6	3AT	Poly(A) polymerase gamma	2.7.7.19	0.450
3uza	T4G	Adenosine receptor A2a	/	0.450
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.449
4afe	GGY	Serine/threonine-protein kinase Nek2	2.7.11.1	0.449
4jbt	ASD	Cytochrome P450 monooxygenase	/	0.449
4u0o	MTA	Lipoyl synthase 2	/	0.449
2xk8	5R1	Serine/threonine-protein kinase Nek2	2.7.11.1	0.448
4k9y	K9Y	Focal adhesion kinase 1	2.7.10.2	0.448
2wo7	ASV	Isopenicillin N synthase	1.21.3.1	0.447
2ydo	ADN	Adenosine receptor A2a	/	0.447
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.447
4gkh	0J9	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.447
4rlh	0WE	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.447
3rey	XAC	Adenosine receptor A2a	/	0.447
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.446
1syn	F89	Thymidylate synthase	/	0.446
1w06	W05	Isopenicillin N synthase	1.21.3.1	0.446
2w9g	TOP	Dihydrofolate reductase	1.5.1.3	0.446
3clr	FAD	Electron transfer flavoprotein subunit alpha	/	0.446
3gkj	HC3	Niemann-Pick C1 protein	/	0.446
3i5x	ANP	ATP-dependent RNA helicase MSS116, mitochondrial	3.6.4.13	0.446
3prf	FP3	Serine/threonine-protein kinase B-raf	2.7.11.1	0.446
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.446
4uoh	ADP	Nucleoside diphosphate kinase	/	0.446
3uzc	T4E	Adenosine receptor A2a	/	0.446
1ejb	INJ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.445
1phe	PIY	Camphor 5-monooxygenase	1.14.15.1	0.445
1ygk	RRC	Pyridoxal kinase	2.7.1.35	0.445
2c59	NAD	GDP-mannose 3,5-epimerase	5.1.3.18	0.445
2in6	839	Wee1-like protein kinase	2.7.10.2	0.445
1lb9	DNQ	Glutamate receptor 2	/	0.444
1n71	COA	Aac(6')-Ii protein	/	0.444
1uzw	CDH	Isopenicillin N synthase	1.21.3.1	0.444
1w7h	3IP	Mitogen-activated protein kinase 14	/	0.444
2a19	ANP	Interferon-induced, double-stranded RNA-activated protein kinase	2.7.11.1	0.444
2bbq	PFG	Thymidylate synthase	/	0.444
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.444
2y60	M8F	Isopenicillin N synthase	1.21.3.1	0.444
3aw9	GDU	NAD-dependent epimerase/dehydratase	/	0.444
3hf6	LX0	Tryptophan 5-hydroxylase 1	1.14.16.4	0.444
5iu4	ZMA	Adenosine receptor A2a	/	0.444
3qak	UKA	Adenosine receptor A2a	/	0.444
1o97	FAD	Electron transfer flavoprotein subunit alpha	/	0.443
1oc1	ASV	Isopenicillin N synthase	1.21.3.1	0.443
1uae	UD1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	/	0.443
2c94	TSF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.443
3sgy	06W	Dihydrofolate reductase	1.5.1.3	0.443
3vg9	ZMA	Adenosine receptor A2a	/	0.443
4k6i	9RA	Retinoic acid receptor RXR-alpha	/	0.443
4twn	B96	Ephrin type-A receptor 3	2.7.10.1	0.443
4tx9	AMZ	Phosphoribosyl isomerase A	/	0.443
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.442
1v8k	ANP	Kinesin-like protein KIF2C	/	0.442
2p1t	3TN	Retinoic acid receptor RXR-alpha	/	0.442
2qk8	MTX	Dihydrofolate reductase	/	0.442
2xk3	XK3	Serine/threonine-protein kinase Nek2	2.7.11.1	0.442
3m4n	PA9	N-acetylornithine carbamoyltransferase	2.1.3.9	0.442
4iar	ERM	5-hydroxytryptamine receptor 1B	/	0.442
4jx1	CAH	Camphor 5-monooxygenase	1.14.15.1	0.442
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.441
1krv	147	Galactoside O-acetyltransferase	2.3.1.18	0.441
2owb	626	Serine/threonine-protein kinase PLK1	2.7.11.21	0.441
3ol5	SAW	Camphor 5-monooxygenase	1.14.15.1	0.441
3t5i	SER_SER_CMT_FAR	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	/	0.441
4a4l	939	Serine/threonine-protein kinase PLK1	2.7.11.21	0.441
4be7	ATP	Type I restriction enzyme EcoR124II R protein	3.1.21.3	0.441
4h6z	ACO	Alpha-tubulin N-acetyltransferase 1	/	0.441
4j4v	SVR	Nucleocapsid protein	/	0.441
5ej5	TD6	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	/	0.441
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.440
1ltz	HBI	Phenylalanine-4-hydroxylase	1.14.16.1	0.440
2rku	R78	Serine/threonine-protein kinase PLK1	2.7.11.21	0.440
2xkf	BX1	Serine/threonine-protein kinase Nek2	2.7.11.1	0.440
3upk	UD1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	/	0.440
3zdf	NAD	Glyceraldehyde-3-phosphate dehydrogenase	/	0.440
4a4o	664	Serine/threonine-protein kinase PLK1	2.7.11.21	0.440
4a9m	P9M	Bromodomain-containing protein 2	/	0.440