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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdyFIDAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdyFIDAldose reductase1.1.1.211.000
1pwmFIDAldose reductase1.1.1.210.661
2pdwFIDAldose reductase1.1.1.210.629
2f2kTGGAldose reductase1.1.1.210.628
2inzOHPAldose reductase1.1.1.210.598
3u2cSUZAldose reductase1.1.1.210.585
2fz8ZSTAldose reductase1.1.1.210.582
3s3gTLTAldose reductase1.1.1.210.572
3ghsLDTAldose reductase1.1.1.210.569
2iqdLPAAldose reductase1.1.1.210.558
2fz9ZSTAldose reductase1.1.1.210.555
2is72CLAldose reductase1.1.1.210.554
3ghtLDTAldose reductase1.1.1.210.551
2nvcITAAldose reductase1.1.1.210.550
2pdu393Aldose reductase1.1.1.210.549
3ghrLDTAldose reductase1.1.1.210.542
1ef3FIDAldose reductase1.1.1.210.540
4gabFIDAldo-keto reductase family 1 member B101.1.10.525
2pd9FIDAldose reductase1.1.1.210.521
3p2vDOYAldose reductase1.1.1.210.521
2pdmZSTAldose reductase1.1.1.210.520
4gca2X9Aldose reductase1.1.1.210.519
2pdkSBIAldose reductase1.1.1.210.513
2hv5ZSTAldose reductase1.1.1.210.508
5liu388Aldo-keto reductase family 1 member B101.1.10.506
2hvnZSTAldose reductase1.1.1.210.505
2pdh47DAldose reductase1.1.1.210.504
2pdlTOLAldose reductase1.1.1.210.504
1ekoI84Aldose reductase1.1.1.210.503
2i17LDTAldose reductase1.1.1.210.503
2hvoZSTAldose reductase1.1.1.210.502
2pdfZSTAldose reductase1.1.1.210.501
1ah0SBIAldose reductase1.1.1.210.500
2i16LDTAldose reductase1.1.1.210.500
2agtFIDAldose reductase1.1.1.210.496
3mb9ZSTAldose reductase1.1.1.210.496
1ieiZESAldose reductase1.1.1.210.495
2dv0ZSTAldose reductase1.1.1.210.495
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.494
4ga8SBIAldo-keto reductase family 1 member B101.1.10.491
2pdxZSTAldose reductase1.1.1.210.486
2pdj393Aldose reductase1.1.1.210.483
1el3I84Aldose reductase1.1.1.210.482
3v35NTIAldose reductase1.1.1.210.481
2f3815MAldo-keto reductase family 1 member C3/0.476
2pzn393Aldose reductase1.1.1.210.476
2ikj393Aldose reductase1.1.1.210.475
3m64393Aldose reductase1.1.1.210.475
4fam0SZAldo-keto reductase family 1 member C3/0.474
2pdp393Aldose reductase1.1.1.210.473
3ghuLDTAldose reductase1.1.1.210.471
3v94WYQPhosphodiesterase/0.469
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.466
4wevSUZAldo-keto reductase family 1 member B101.1.10.465
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.462
2duzZSTAldose reductase1.1.1.210.461
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
3ld5LDTAldose reductase1.1.1.210.457
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.457
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.455
2iki388Aldose reductase1.1.1.210.454
2xupTZ5Acetylcholinesterase3.1.1.70.454
3zkuHCVIsopenicillin N synthase1.21.3.10.452
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
4c5oFADPutative monooxygenase/0.449
2xuoTZ4Acetylcholinesterase3.1.1.70.447
4dbs0HVAldo-keto reductase family 1 member C3/0.447
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.447
1obnASVIsopenicillin N synthase1.21.3.10.446
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3f3y4OABile salt sulfotransferase2.8.2.140.446
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1z3n3NAAldose reductase1.1.1.210.445
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.444
1ry0PG2Aldo-keto reductase family 1 member C3/0.443
2vbpVB1Isopenicillin N synthase1.21.3.10.443
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.443
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
7catNDPCatalase1.11.1.60.443
1fvpFMANon-fluorescent flavoprotein/0.442
1t40ID5Aldose reductase1.1.1.210.442
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2fzdTOLAldose reductase1.1.1.210.441
2iviACWIsopenicillin N synthase1.21.3.10.441
3g5eQ74Aldose reductase1.1.1.210.441
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
1blzACVIsopenicillin N synthase1.21.3.10.440
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
3lboLDTAldose reductase1.1.1.210.440
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440