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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdmZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdmZSTAldose reductase1.1.1.211.000
2fz8ZSTAldose reductase1.1.1.210.739
1z8962PAldose reductase1.1.1.210.690
1t40ID5Aldose reductase1.1.1.210.671
2iki388Aldose reductase1.1.1.210.662
2ikj393Aldose reductase1.1.1.210.636
2dv0ZSTAldose reductase1.1.1.210.611
2pdiZSTAldose reductase1.1.1.210.605
2hv5ZSTAldose reductase1.1.1.210.599
2fz9ZSTAldose reductase1.1.1.210.594
2pdg47DAldose reductase1.1.1.210.581
1t41ID5Aldose reductase1.1.1.210.575
2pdxZSTAldose reductase1.1.1.210.575
3m64393Aldose reductase1.1.1.210.572
2pdfZSTAldose reductase1.1.1.210.571
1z3n3NAAldose reductase1.1.1.210.567
2hvnZSTAldose reductase1.1.1.210.565
3lqlLDTAldose reductase1.1.1.210.565
4gca2X9Aldose reductase1.1.1.210.564
2duzZSTAldose reductase1.1.1.210.560
3ghrLDTAldose reductase1.1.1.210.558
2ikhLITAldose reductase1.1.1.210.557
3m4h388Aldose reductase1.1.1.210.556
2pdu393Aldose reductase1.1.1.210.555
3lenZSTAldose reductase1.1.1.210.554
2qxwLDTAldose reductase1.1.1.210.551
2pdh47DAldose reductase1.1.1.210.548
3mb9ZSTAldose reductase1.1.1.210.547
3lboLDTAldose reductase1.1.1.210.546
2pd5ZSTAldose reductase1.1.1.210.542
2i16LDTAldose reductase1.1.1.210.541
2duxZSTAldose reductase1.1.1.210.540
3ld5LDTAldose reductase1.1.1.210.536
2hvoZSTAldose reductase1.1.1.210.535
2agtFIDAldose reductase1.1.1.210.533
3ghsLDTAldose reductase1.1.1.210.532
3ghuLDTAldose reductase1.1.1.210.531
2pdbZSTAldose reductase1.1.1.210.525
3ghtLDTAldose reductase1.1.1.210.524
3g5eQ74Aldose reductase1.1.1.210.523
2pdj393Aldose reductase1.1.1.210.522
1pwlBFIAldose reductase1.1.1.210.519
2pdp393Aldose reductase1.1.1.210.516
2pzn393Aldose reductase1.1.1.210.516
2pdc393Aldose reductase1.1.1.210.514
2pdn47DAldose reductase1.1.1.210.514
3t423T4Aldose reductase1.1.1.210.514
3m0iZSTAldose reductase1.1.1.210.510
2i17LDTAldose reductase1.1.1.210.509
3mc5393Aldose reductase1.1.1.210.498
1ieiZESAldose reductase1.1.1.210.491
2pdlTOLAldose reductase1.1.1.210.491
3lz5LDTAldose reductase1.1.1.210.488
1zuaTOLAldo-keto reductase family 1 member B101.1.10.483
1frbZSTAldose reductase-related protein 2/0.474
4yu153NAldose reductase1.1.1.210.474
2pdyFIDAldose reductase1.1.1.210.471
1pwmFIDAldose reductase1.1.1.210.466
1us0LDTAldose reductase1.1.1.210.454
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
2fzdTOLAldose reductase1.1.1.210.450
2pdq47DAldose reductase1.1.1.210.448
3zkyWT4Isopenicillin N synthase1.21.3.10.446
4li61XOTankyrase-12.4.2.300.445
3v94WYQPhosphodiesterase/0.443
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1ef3FIDAldose reductase1.1.1.210.441
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.441