sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pdj | 393 | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 1.000 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.630 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.626 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.598 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.571 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.570 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.568 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.559 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.556 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.551 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.547 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.543 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.543 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.538 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.538 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.532 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.531 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.529 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.528 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.528 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.526 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.526 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.525 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.524 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.522 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.522 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.522 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.522 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.522 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.521 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.521 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.521 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.520 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.519 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.518 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.517 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.516 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.514 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.513 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.512 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.512 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.509 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.509 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.509 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.509 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.509 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.508 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.508 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.506 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.504 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.503 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.502 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.501 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.500 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.499 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.498 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.497 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.497 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.496 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.495 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.493 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.493 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.492 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.491 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.491 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.491 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.491 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.490 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.490 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.489 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.488 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.486 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.483 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.483 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.482 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.482 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.478 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.478 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.477 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.475 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.475 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.474 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.471 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.470 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.469 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.469 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.468 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.468 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.467 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.467 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.462 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 3hgg | CHD | CmeR | / | 0.461 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.460 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.460 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.458 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2yhu | WHF | Pteridine reductase | / | 0.454 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.452 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.452 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.452 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.452 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.451 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.450 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.450 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
| 4j7g | TRH | PCZA361.3 | / | 0.450 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.448 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.448 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.447 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.446 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.446 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.445 | |
| 4dyb | 0MH | Nucleoprotein | / | 0.445 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.445 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.444 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.444 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.444 | |
| 2rcw | AAI | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3ocx | 2AM | Lipoprotein E | / | 0.443 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.442 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2y1w | 849 | Histone-arginine methyltransferase CARM1 | / | 0.442 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.442 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4phl | PIL | Phosphodiesterase | / | 0.442 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1uk1 | FRQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 4xwt | U5P | Ribonuclease J | / | 0.441 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.440 | |
| 3c1o | NAP | Eugenol synthase | / | 0.440 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.440 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.440 |