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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pd9FIDAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2pd9FIDAldose reductase1.1.1.211.000
2agtFIDAldose reductase1.1.1.210.720
2pdwFIDAldose reductase1.1.1.210.699
2is72CLAldose reductase1.1.1.210.681
2pdkSBIAldose reductase1.1.1.210.655
1ef3FIDAldose reductase1.1.1.210.645
1ekoI84Aldose reductase1.1.1.210.639
2f2kTGGAldose reductase1.1.1.210.638
2pdyFIDAldose reductase1.1.1.210.624
3p2vDOYAldose reductase1.1.1.210.616
1pwmFIDAldose reductase1.1.1.210.612
2nvcITAAldose reductase1.1.1.210.599
4gabFIDAldo-keto reductase family 1 member B101.1.10.597
3v35NTIAldose reductase1.1.1.210.596
3s3gTLTAldose reductase1.1.1.210.594
1zuaTOLAldo-keto reductase family 1 member B101.1.10.586
3u2cSUZAldose reductase1.1.1.210.585
2pdj393Aldose reductase1.1.1.210.582
5liu388Aldo-keto reductase family 1 member B101.1.10.581
1ah0SBIAldose reductase1.1.1.210.566
2fzdTOLAldose reductase1.1.1.210.558
2inzOHPAldose reductase1.1.1.210.558
2pdu393Aldose reductase1.1.1.210.553
1el3I84Aldose reductase1.1.1.210.550
3m4h388Aldose reductase1.1.1.210.547
2fzbTOLAldose reductase1.1.1.210.543
4wevSUZAldo-keto reductase family 1 member B101.1.10.537
3lqlLDTAldose reductase1.1.1.210.534
3lz5LDTAldose reductase1.1.1.210.534
3ghtLDTAldose reductase1.1.1.210.529
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.528
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.525
3h4gFIDAlcohol dehydrogenase [NADP(+)]1.1.1.20.523
4gca2X9Aldose reductase1.1.1.210.521
2vrjNCWBeta-glucosidase A3.2.1.210.520
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.519
2ikj393Aldose reductase1.1.1.210.519
2pdlTOLAldose reductase1.1.1.210.517
1az1ALRAldose reductase1.1.1.210.513
2iqdLPAAldose reductase1.1.1.210.511
1zq5E04Aldo-keto reductase family 1 member C3/0.510
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.509
2hv5ZSTAldose reductase1.1.1.210.508
2iki388Aldose reductase1.1.1.210.508
1t41ID5Aldose reductase1.1.1.210.505
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.505
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.503
4paaTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.503
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.502
1us0LDTAldose reductase1.1.1.210.501
2ipw2CLAldose reductase1.1.1.210.500
2hvnZSTAldose reductase1.1.1.210.499
3lboLDTAldose reductase1.1.1.210.499
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.498
2pdxZSTAldose reductase1.1.1.210.498
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.496
1tfz8694-hydroxyphenylpyruvate dioxygenase1.13.11.270.493
8catNDPCatalase1.11.1.60.493
1ry0PG2Aldo-keto reductase family 1 member C3/0.492
2duxZSTAldose reductase1.1.1.210.492
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.491
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.489
3qeoLLTDeoxycytidine kinase2.7.1.740.489
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.489
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.489
1blzACVIsopenicillin N synthase1.21.3.10.488
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.488
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.487
3f3y4OABile salt sulfotransferase2.8.2.140.487
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.487
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.486
3zkyWT4Isopenicillin N synthase1.21.3.10.486
1rxjBNIStreptavidin/0.485
2pdfZSTAldose reductase1.1.1.210.485
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.485
4xwtU5PRibonuclease J/0.485
2pdc393Aldose reductase1.1.1.210.484
2y6fM9FIsopenicillin N synthase1.21.3.10.484
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.484
4fam0SZAldo-keto reductase family 1 member C3/0.484
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.484
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.483
1z8962PAldose reductase1.1.1.210.482
2f3815MAldo-keto reductase family 1 member C3/0.481
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.481
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.480
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.480
4blcNDPCatalase1.11.1.60.479
4h7c10HAldo-keto reductase family 1 member C3/0.479
1oc1ASVIsopenicillin N synthase1.21.3.10.478
2w3mFOLDihydrofolate reductase1.5.1.30.478
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.478
1dlrMXADihydrofolate reductase1.5.1.30.477
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.477
3r7mSUZAldo-keto reductase family 1 member C3/0.477
1ycgFMNNitric oxide reductase10.476
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.476
3n0hTOPDihydrofolate reductase1.5.1.30.476
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.476
1upw444Oxysterols receptor LXR-beta/0.475
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.475
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.475
2hzqSTRApolipoprotein D/0.474
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.474
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
4dbs0HVAldo-keto reductase family 1 member C3/0.474
1pqc444Oxysterols receptor LXR-beta/0.473
1zz1SHHHistone deacetylase-like amidohydrolase3.5.10.473
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.473
1dlsMTXDihydrofolate reductase1.5.1.30.472
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
2tohHBITyrosine 3-monooxygenase1.14.16.20.472
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.472
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.471
3dr7GPDGDP-perosamine synthase/0.471
1hb1OCVIsopenicillin N synthase1.21.3.10.470
1hfrMOTDihydrofolate reductase1.5.1.30.470
1kmsLIHDihydrofolate reductase1.5.1.30.470
2aj4ANPGalactokinase2.7.1.60.470
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.470
2r6jNDPEugenol synthase 11.1.1.3180.470
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.470
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.470
1obnASVIsopenicillin N synthase1.21.3.10.469
1w29TS16,7-dimethyl-8-ribityllumazine synthase2.5.1.780.469
1x8lOXRRetinol dehydratase/0.469
2vdyHCYCorticosteroid-binding globulin/0.469
3fx4FX4Alcohol dehydrogenase [NADP(+)]1.1.1.20.469
1dgbNDPCatalase1.11.1.60.468
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.468
3g5eQ74Aldose reductase1.1.1.210.468
4dbw511Aldo-keto reductase family 1 member C3/0.468
1ut6A8NAcetylcholinesterase3.1.1.70.467
2aclL05Oxysterols receptor LXR-alpha/0.467
2wo7ASVIsopenicillin N synthase1.21.3.10.467
2xi4AFTAcetylcholinesterase3.1.1.70.467
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.467
3r8gIZPAldo-keto reductase family 1 member C3/0.467
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.467
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.466
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
1pwlBFIAldose reductase1.1.1.210.466
1qjfACSIsopenicillin N synthase1.21.3.10.466
3zoiM2WIsopenicillin N synthase1.21.3.10.466
1p0pBCHCholinesterase3.1.1.80.465
1ry8RUTAldo-keto reductase family 1 member C3/0.465
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.465
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2b8jADNClass B acid phosphatase3.1.3.20.465
2e94364Geranylgeranyl pyrophosphate synthase/0.465
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.465
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.465
3r6iJMSAldo-keto reductase family 1 member C3/0.465
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.465
3v94WYQPhosphodiesterase/0.465
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4li61XOTankyrase-12.4.2.300.465
4pnmNU1Tankyrase-22.4.2.300.465
1s36CEIObelin/0.464
1zgbA1EAcetylcholinesterase3.1.1.70.464
2vbpVB1Isopenicillin N synthase1.21.3.10.464
3cuiX4SExoglucanase/xylanase3.2.1.910.464
3nn6HNK6-hydroxy-L-nicotine oxidase/0.464
3nu03TUDihydrofolate reductase1.5.1.30.464
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.464
4i5xFLFAldo-keto reductase family 1 member B101.1.10.464
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.463
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.463
1zgcA2EAcetylcholinesterase3.1.1.70.463
2a8gGNGAvidin/0.463
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.463
2xufTZ4Acetylcholinesterase3.1.1.70.463
3i9kNADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase3.2.2.60.463
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
3uyk0CXProbable NDP-rhamnosyltransferase/0.463
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.462
1odnAPVIsopenicillin N synthase1.21.3.10.462
2bjsACVIsopenicillin N synthase1.21.3.10.462
2cekN8TAcetylcholinesterase3.1.1.70.462
2pdp393Aldose reductase1.1.1.210.462
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3zj7C1KStrictosidine-O-beta-D-glucosidase3.2.1.1050.462
7catNDPCatalase1.11.1.60.462
1dgfNDPCatalase1.11.1.60.461
1pq6965Oxysterols receptor LXR-beta/0.461
1xf0ASDAldo-keto reductase family 1 member C3/0.461
2pdbZSTAldose reductase1.1.1.210.461
2xuiTZ5Acetylcholinesterase3.1.1.70.461
4dbuBT9Aldo-keto reductase family 1 member C3/0.461
4jpg1OXPyruvate kinase PKM2.7.1.400.461
4kn104JFolate receptor beta/0.461
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
1lelBH7Avidin/0.460
1s9dAFBCytohesin-2/0.460
1s9dAFBADP-ribosylation factor 1/0.460
2dhfDZFDihydrofolate reductase1.5.1.30.460
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.460
2pdh47DAldose reductase1.1.1.210.460
1drfFOLDihydrofolate reductase1.5.1.30.459
1hb3SCVIsopenicillin N synthase1.21.3.10.459
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
2gywOBIAcetylcholinesterase3.1.1.70.459
2pb1NFGGlucan 1,3-beta-glucosidase/0.459
2pd5ZSTAldose reductase1.1.1.210.459
2q0gUPUPoly(A) polymerase, putative/0.459
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.459
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.459
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.459
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
4jq3ZOMAldo-keto reductase family 1 member C2/0.459
4kebFOLDihydrofolate reductase1.5.1.30.459
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.459
5agkH4BNitric oxide synthase, brain1.14.13.390.459
1d3dBZTProthrombin3.4.21.50.458
1gt5BZQOdorant-binding protein/0.458
1pkfEPDEpothilone C/D epoxidase1.140.458
2ha6SCKAcetylcholinesterase3.1.1.70.458
2qg4UGAUDP-glucose 6-dehydrogenase1.1.1.220.458
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3m0iZSTAldose reductase1.1.1.210.458
4m6kFOLDihydrofolate reductase1.5.1.30.458
5cxv0HKMuscarinic acetylcholine receptor M1/0.458
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2fzjDH3Dihydrofolate reductase1.5.1.30.457
2oazI96Methionine aminopeptidase 2/0.457
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
4n3l2FNProthrombin3.4.21.50.457
4yu153NAldose reductase1.1.1.210.457
1dggNDPCatalase1.11.1.60.456
1m67BOAGlycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal1.1.1.80.456
1s3uTQDDihydrofolate reductase1.5.1.30.456
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.456
1u65CP0Acetylcholinesterase3.1.1.70.456
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2cleF6FTryptophan synthase alpha chain/0.456
2vbdV10Isopenicillin N synthase1.21.3.10.456
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
4bjbP34Tankyrase-22.4.2.300.456
1bk0ACVIsopenicillin N synthase1.21.3.10.455
1kw9BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.455
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
2gmvUN8Phosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.455
2vqqTFGHistone deacetylase 43.5.1.980.455
2xltNA0Putative flavin-containing monooxygenase/0.455
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.455
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3qfrFADNADPH--cytochrome P450 reductase/0.455
3stdMQ0Scytalone dehydratase4.2.1.940.455
4jqaID8Aldo-keto reductase family 1 member C2/0.455
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
5epvACPBlue-light-activated histidine kinase2.7.13.30.455
1enpNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.454
2pdn47DAldose reductase1.1.1.210.454
2po3T4K4-dehydrase/0.454
3ug8IMNAldo-keto reductase family 1 member C3/0.454
3zkuHCVIsopenicillin N synthase1.21.3.10.454
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
1ohjCOPDihydrofolate reductase1.5.1.30.453
2f99AKVAklanonic acid methyl ester cyclase AcmA5.5.1.230.453
2ikhLITAldose reductase1.1.1.210.453
2jb4A14Isopenicillin N synthase1.21.3.10.453
3c3dFO12-phospho-L-lactate transferase/0.453
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3gyf51PDihydrofolate reductase1.5.1.30.453
3k7tFAD6-hydroxy-L-nicotine oxidase/0.453
3lenZSTAldose reductase1.1.1.210.453
3mb9ZSTAldose reductase1.1.1.210.453
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
5a4vQUEGlutathione S-transferase F22.5.1.180.453
4mqt2CUMuscarinic acetylcholine receptor M2/0.453
1dghNDPCatalase1.11.1.60.452
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
1lnmDTXBilin-binding protein/0.452
1t40ID5Aldose reductase1.1.1.210.452
2zhe13UProthrombin3.4.21.50.452
2zs9ADPPantothenate kinase2.7.1.330.452
3nxtD2EDihydrofolate reductase1.5.1.30.452
4bb3KKAIsopenicillin N synthase1.21.3.10.452
5cc9DDFDihydrofolate reductase1.5.1.30.452
1re0AFBADP-ribosylation factor 1/0.451
1re0AFBARF guanine-nucleotide exchange factor 1/0.451
1votHUPAcetylcholinesterase3.1.1.70.451
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1zgv501Prothrombin3.4.21.50.451
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.451
2gvcFADThiol-specific monooxygenase1.14.130.451
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
2pdmZSTAldose reductase1.1.1.210.451
2r7nADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.451
2y60M8FIsopenicillin N synthase1.21.3.10.451
3r8hZOMAldo-keto reductase family 1 member C3/0.451
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.451
4dyp0MSNucleoprotein/0.451
4kfjFOLDihydrofolate reductase1.5.1.30.451
2rh1CAUBeta-2 adrenergic receptor/0.451
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.450
1fmlRTLRetinol dehydratase/0.450
1z5uCMPClass B acid phosphatase/0.450
2hvoZSTAldose reductase1.1.1.210.450
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.450
3rl45GPMetallophosphoesterase MPPED23.10.450
3ugrIMNAldo-keto reductase family 1 member C3/0.450
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4jtqFLPAldo-keto reductase family 1 member C2/0.450
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
1w06W05Isopenicillin N synthase1.21.3.10.449
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.449
2vqoTFGHistone deacetylase 43.5.1.980.449
3af1GDPPantothenate kinase2.7.1.330.449
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.449
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3nwlNDPCatalase1.11.1.60.449
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.449
1gm8SOXPenicillin G acylase3.5.1.110.448
1rkwPNTHTH-type transcriptional regulator QacR/0.448
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.448
2jl1NAPTriphenylmethane reductase/0.448
2vcmM11Isopenicillin N synthase1.21.3.10.448
3ai0PNWBeta-glucosidase/0.448
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3fznD7KBenzoylformate decarboxylase4.1.1.70.448
3ghuLDTAldose reductase1.1.1.210.448
3vf60H6Glucokinase2.7.1.20.448
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4qa0SHHHistone deacetylase 83.5.1.980.448
5ctoNTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.448
5a8eXTKBeta-1 adrenergic receptor/0.448
1d3pBT3Prothrombin3.4.21.50.447
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1oytFSNProthrombin3.4.21.50.447
1p8dCO1Oxysterols receptor LXR-beta/0.447
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.447
1ygjRMCPyridoxal kinase2.7.1.350.447
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.447
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
3khuUPGUDP-glucose 6-dehydrogenase1.1.1.220.447
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.447
4dyn0MRNucleoprotein/0.447
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.447
4uugPXGBranched-chain amino acid aminotransferase, putative/0.447
1d6w00RProthrombin3.4.21.50.446
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.446
1uzwCDHIsopenicillin N synthase1.21.3.10.446
1vkgCRIHistone deacetylase 83.5.1.980.446
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2bdyUNBProthrombin3.4.21.50.446
2ipjFFAAldo-keto reductase family 1 member C2/0.446
2qcxPF1Aminopyrimidine aminohydrolase/0.446
2xugTZ4Acetylcholinesterase3.1.1.70.446
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3ojxFADNADPH--cytochrome P450 reductase/0.446
4bb2STRCorticosteroid-binding globulin/0.446
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.446
1eveE20Acetylcholinesterase3.1.1.70.445
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.445
1s2cFLFAldo-keto reductase family 1 member C3/0.445
1z3n3NAAldose reductase1.1.1.210.445
2cf9348Prothrombin3.4.21.50.445
2ea4F79Methionine aminopeptidase 2/0.445
2gl0ADNUncharacterized protein/0.445
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.445
2xukTZ5Acetylcholinesterase3.1.1.70.445
3l3rOAGDihydrofolate reductase1.5.1.30.445
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.445
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.445
1jf0CZHObelin/0.444
1pq944BOxysterols receptor LXR-beta/0.444
1s3wTQTDihydrofolate reductase1.5.1.30.444
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.444
2dv0ZSTAldose reductase1.1.1.210.444
2i16LDTAldose reductase1.1.1.210.444
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.444
2pdiZSTAldose reductase1.1.1.210.444
2qjpANJCytochrome b/0.444
2wu4HBPAcetylcholinesterase3.1.1.70.444
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.444
3c1oNAPEugenol synthase/0.444
3cr0809Wee1-like protein kinase2.7.10.20.444
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
4a16H34Acetylcholinesterase3.1.1.70.444
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.444
4phlPILPhosphodiesterase/0.444
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
1q83TZ5Acetylcholinesterase3.1.1.70.443
1w76GNTAcetylcholinesterase3.1.1.70.443
1z71L17Prothrombin3.4.21.50.443
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.443
2bu9HFVIsopenicillin N synthase1.21.3.10.443
2xuhTZ4Acetylcholinesterase3.1.1.70.443
3b9gIMHIAG-nucleoside hydrolase/0.443
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3ghrLDTAldose reductase1.1.1.210.443
3gi2GHWDihydrofolate reductase1.5.1.30.443
3gwfFADCyclohexanone monooxygenase/0.443
3iu9T07Methionine aminopeptidase 2/0.443
3m64393Aldose reductase1.1.1.210.443
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.443
3pn1IVHDNA ligase/0.443
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.443
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.443
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.443
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4araC56Acetylcholinesterase3.1.1.70.443
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.443
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.443
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4yfy0FXVioF/0.443
2y0468HBeta-1 adrenergic receptor/0.443
1frbZSTAldose reductase-related protein 2/0.442
1ja1FMNNADPH--cytochrome P450 reductase/0.442
1odcA8BAcetylcholinesterase3.1.1.70.442
1w4lGL8Acetylcholinesterase3.1.1.70.442
2bd0BIOSepiapterin reductase/0.442
2pucGUNHTH-type transcriptional repressor PurR/0.442
3af0GDPPantothenate kinase2.7.1.330.442
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.442
3d2dRENReticuline oxidase1.21.3.30.442
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.442
3up3XCAaceDAF-12/0.442
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.442
4hh4SAHCcbJ/0.442
4jvmXDIEstrogen sulfotransferase2.8.2.40.442
4kn0MTXFolate receptor beta/0.442
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
1stdBFSScytalone dehydratase4.2.1.940.441
2getCOKPantothenate kinase2.7.1.330.441
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2vq3NAPMetalloreductase STEAP3/0.441
2ycwCAUBeta-1 adrenergic receptor/0.441
2zc922UProthrombin3.4.21.50.441
3mjrAC2Deoxycytidine kinase2.7.1.740.441
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.441
4b7754MBeta-secretase 13.4.23.460.441
4bvhOCZNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.441
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
4fal0T0Aldo-keto reductase family 1 member C3/0.441
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.441
4kxjP34Nucleoprotein/0.441
1mdtAPUDiphtheria toxin/0.440
1nceCB3Thymidylate synthase/0.440
1yhjR6CPyridoxal kinase2.7.1.350.440
1yw8A75Methionine aminopeptidase 2/0.440
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.440
2iuzD1HEndochitinase B13.2.1.140.440
2oacGTBGlutathione S-transferase P 12.5.1.180.440
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.440
2uuk897Prothrombin3.4.21.50.440
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.440
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
4epq0RRPoly(ADP-ribose) glycohydrolase/0.440
4jq2SUZAldo-keto reductase family 1 member C2/0.440