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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2p2h994Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2p2h994Vascular endothelial growth factor receptor 22.7.10.11.000
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.589
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.583
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.573
4nks2M2Fibroblast growth factor receptor 1/0.563
4nka2K7Fibroblast growth factor receptor 1/0.551
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.547
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.544
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.538
1m17AQ4Epidermal growth factor receptor2.7.10.10.537
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.532
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.529
4f640S8Fibroblast growth factor receptor 1/0.527
3s4qNK0Mitogen-activated protein kinase 14/0.526
4c62XWWTyrosine-protein kinase JAK2/0.522
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.520
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.519
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.519
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.518
4jr3KJREpidermal growth factor receptor2.7.10.10.518
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.517
4gk3L87Ephrin type-A receptor 32.7.10.10.517
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.516
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.516
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.516
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.515
5e8xSTUTGF-beta receptor type-12.7.11.300.515
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.512
2of2547Tyrosine-protein kinase Lck2.7.10.20.510
2yn8STUEphrin type-B receptor 42.7.10.10.509
2itnANPEpidermal growth factor receptor2.7.10.10.508
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.507
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.507
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.506
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.505
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.504
3ac2KSETyrosine-protein kinase Lck2.7.10.20.504
4fob0USALK tyrosine kinase receptor2.7.10.10.503
1u54ACPActivated CDC42 kinase 1/0.502
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.502
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.502
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.501
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.499
2fgiPD1Fibroblast growth factor receptor 1/0.499
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.499
3vjoANPEpidermal growth factor receptor2.7.10.10.499
4nk92K5Fibroblast growth factor receptor 1/0.499
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.499
2qo9ANPEphrin type-A receptor 32.7.10.10.498
4id71G0Activated CDC42 kinase 1/0.498
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.498
1zyjBI5Mitogen-activated protein kinase 14/0.497
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.497
4i231C9Epidermal growth factor receptor2.7.10.10.497
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.496
2itqITQEpidermal growth factor receptor2.7.10.10.496
2y6o1N1Ephrin type-A receptor 42.7.10.10.496
2hk51BMTyrosine-protein kinase HCK2.7.10.20.495
2q0bACPFibroblast growth factor receptor 2/0.495
3zewSTUEphrin type-B receptor 42.7.10.10.495
2xyuQ9GEphrin type-A receptor 42.7.10.10.494
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.494
3js2VM1Fibroblast growth factor receptor 1/0.494
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.494
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.494
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.493
2hog710Serine/threonine-protein kinase Chk12.7.11.10.493
2of4979Tyrosine-protein kinase Lck2.7.10.20.493
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.493
3vs3VSETyrosine-protein kinase HCK2.7.10.20.493
4gk2L66Ephrin type-A receptor 32.7.10.10.493
4riyADPEpidermal growth factor receptor2.7.10.10.493
4hjoAQ4Epidermal growth factor receptor2.7.10.10.490
2eb3ANPEpidermal growth factor receptor2.7.10.10.489
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.488
4wkqIREEpidermal growth factor receptor2.7.10.10.488
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.487
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.487
2itzIREEpidermal growth factor receptor2.7.10.10.486
4cd0AWJALK tyrosine kinase receptor2.7.10.10.486
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.485
4aa5NQBMitogen-activated protein kinase 14/0.485
4fnzNZFALK tyrosine kinase receptor2.7.10.10.485
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.485
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.484
4dce0JFALK tyrosine kinase receptor2.7.10.10.484
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.483
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.483
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.483
2py3ACPFibroblast growth factor receptor 2/0.482
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.481
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.481
3uvqFS8Mitogen-activated protein kinase 14/0.481
4jq7KJQEpidermal growth factor receptor2.7.10.10.481
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.480
3w33W19Epidermal growth factor receptor2.7.10.10.480
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.480
2balPQAMitogen-activated protein kinase 14/0.479
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.479
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.479
4jq8KJ8Epidermal growth factor receptor2.7.10.10.479
1agwSU2Fibroblast growth factor receptor 1/0.478
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.478
4j97ACPFibroblast growth factor receptor 2/0.478
4kiq1RAMitogen-activated protein kinase 14/0.478
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.477
2itwITQEpidermal growth factor receptor2.7.10.10.477
2pwlACPFibroblast growth factor receptor 2/0.476
2rg6287Mitogen-activated protein kinase 14/0.476
2xp2VGHALK tyrosine kinase receptor2.7.10.10.476
3zh8C58Protein kinase C iota type2.7.11.130.476
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.476
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.476
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.475
2itvANPEpidermal growth factor receptor2.7.10.10.475
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.475
3fklFKLMitogen-activated protein kinase 14/0.475
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.474
3dt1P40Mitogen-activated protein kinase 14/0.474
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.473
3tucFPWTyrosine-protein kinase SYK2.7.10.20.473
1bygSTUTyrosine-protein kinase CSK/0.472
1vjy460TGF-beta receptor type-12.7.11.300.472
2vwx7X4Ephrin type-B receptor 42.7.10.10.472
3ac1KZITyrosine-protein kinase Lck2.7.10.20.472
4g2fC07Ephrin type-A receptor 32.7.10.10.472
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.471
2xvdAS6Ephrin type-B receptor 42.7.10.10.471
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.471
4eh60ONMitogen-activated protein kinase 14/0.471
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.471
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
2zybKSLTyrosine-protein kinase Lck2.7.10.20.470
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.470
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.470
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.470
2itpAEEEpidermal growth factor receptor2.7.10.10.469
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.469
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.469
4ic7ANPMitogen-activated protein kinase 72.7.11.240.469
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.468
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.468
3gfeP37Mitogen-activated protein kinase 14/0.468
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.468
4gk4L90Ephrin type-A receptor 32.7.10.10.468
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.467
2vwu7X1Ephrin type-B receptor 42.7.10.10.467
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.467
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.467
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.467
4hvh19RTyrosine-protein kinase JAK32.7.10.20.467
1oecAA2Fibroblast growth factor receptor 2/0.466
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.466
3flwFLWMitogen-activated protein kinase 14/0.466
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.466
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.465
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.464
1xkkFMMEpidermal growth factor receptor2.7.10.10.464
2vd5BI8Myotonin-protein kinase2.7.11.10.464
3uvp048Mitogen-activated protein kinase 14/0.464
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.464
5aaaVGHALK tyrosine kinase receptor2.7.10.10.464
3a62STURibosomal protein S6 kinase beta-12.7.11.10.463
3fln3FNMitogen-activated protein kinase 14/0.463
4c58824Cyclin-G-associated kinase2.7.11.10.463
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.462
2i0ePDSProtein kinase C beta type2.7.11.130.461
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.461
5e8wSTUTGF-beta receptor type-12.7.11.300.461
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.460
2rg5279Mitogen-activated protein kinase 14/0.460
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.460
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.460
2xa4AZ5Tyrosine-protein kinase JAK2/0.459
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.459
4btkDTQTau-tubulin kinase 12.7.11.10.459
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.459
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
1zrzBI1Protein kinase C iota type2.7.11.130.458
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4hvg19QTyrosine-protein kinase JAK32.7.10.20.458
3fskRO6Mitogen-activated protein kinase 14/0.457
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.457
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.457
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.457
2x9fX9FEphrin type-B receptor 42.7.10.10.456
3gc9B45Mitogen-activated protein kinase 112.7.11.240.456
3l8xN4DMitogen-activated protein kinase 14/0.456
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.456
1di9MSQMitogen-activated protein kinase 14/0.455
2pz5ACPFibroblast growth factor receptor 2/0.455
2pzpACPFibroblast growth factor receptor 2/0.455
4jrvKJVEpidermal growth factor receptor2.7.10.10.455
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.455
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.454
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.454
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.454
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.454
3w2rW2REpidermal growth factor receptor2.7.10.10.454
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.454
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.454
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.453
2ittAEEEpidermal growth factor receptor2.7.10.10.453
2j0k4STFocal adhesion kinase 12.7.10.20.453
2vx17X8Ephrin type-B receptor 42.7.10.10.453
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.453
3eb0DRKUncharacterized protein/0.453
3fi4FI4Mitogen-activated protein kinase 14/0.453
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.453
3mpt1GKMitogen-activated protein kinase 14/0.453
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.453
4aa4QC0Mitogen-activated protein kinase 14/0.453
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.453
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.453
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.452
1py5PY1TGF-beta receptor type-12.7.11.300.452
2j7t274Serine/threonine-protein kinase 102.7.11.10.452
2qocANPEphrin type-A receptor 32.7.10.10.452
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.452
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.452
4kip1R9Mitogen-activated protein kinase 14/0.452
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.452
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.451
1u4dDBQActivated CDC42 kinase 1/0.451
2wouZZFTGF-beta receptor type-12.7.11.300.451
3nww3NWMitogen-activated protein kinase 14/0.451
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.451
4anqVGHALK tyrosine kinase receptor2.7.10.10.451
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.451
4jia1K3Tyrosine-protein kinase JAK2/0.451
1w84L12Mitogen-activated protein kinase 14/0.450
2vwy7X5Ephrin type-B receptor 42.7.10.10.450
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.450
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.450
4aotGW8Serine/threonine-protein kinase 102.7.11.10.450
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.450
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.449
3hx4ANPCalmodulin-domain protein kinase 1/0.449
3mvl38PMitogen-activated protein kinase 14/0.449
3ocgOCGMitogen-activated protein kinase 14/0.449
3vryB43Tyrosine-protein kinase HCK2.7.10.20.449
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.449
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.448
3gubGUBDeath-associated protein kinase 12.7.11.10.448
3mvm39PMitogen-activated protein kinase 14/0.448
3wmxNADNAD dependent epimerase/dehydratase/0.448
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.448
1jpaANPEphrin type-B receptor 22.7.10.10.447
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.447
3tk3CPZCytochrome P450 2B41.14.14.10.447
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.447
1rw8580TGF-beta receptor type-12.7.11.300.446
2i40BLZCyclin-dependent kinase 22.7.11.220.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.446
3gxlQIGTGF-beta receptor type-12.7.11.300.446
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.446
3q5iANPProtein kinase, putative/0.446
4f630S7Fibroblast growth factor receptor 1/0.446
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.445
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.445
4b99R4LMitogen-activated protein kinase 72.7.11.240.445
4h3g10QBeta-secretase 13.4.23.460.445
4lopSB4Mitogen-activated protein kinase 14/0.445
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.444
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.444
3mtfA3FActivin receptor type-12.7.11.300.444
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4bb432WEphrin type-B receptor 42.7.10.10.444
4c61LMMTyrosine-protein kinase JAK2/0.444
4ccbOFGALK tyrosine kinase receptor2.7.10.10.444
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.444
4g7gVFVLanosterol 14-alpha-demethylase/0.444
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.443
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.443
1wvxBD4Death-associated protein kinase 12.7.11.10.442
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.442
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.442
2h96893Mitogen-activated protein kinase 82.7.11.240.441
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.441
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.441
4jpe1M7Beta-secretase 13.4.23.460.441
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.441
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.440
3oom507Activin receptor type-12.7.11.300.440
3w32W32Epidermal growth factor receptor2.7.10.10.440
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.440