sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 1.000 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.766 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.631 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.617 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.605 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.599 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.598 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.596 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.592 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.591 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.590 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.588 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.585 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.584 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.583 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.578 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.575 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.573 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.570 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.567 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.565 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.565 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.563 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.497 | |
| 3p9t | TCL | Repressor | / | 0.493 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.493 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.491 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.488 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.488 | |
| 2p15 | EZT | Estrogen receptor | / | 0.483 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.483 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.483 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.483 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.483 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.482 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.481 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.480 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.480 | |
| 3aba | FLI | Cytochrome P450 | / | 0.477 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.477 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.477 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.477 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.476 | |
| 2wpw | ACO | Orf14 | / | 0.476 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.476 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.475 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.474 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.474 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.474 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.474 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.473 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.473 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.473 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.472 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.472 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.472 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.471 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.471 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.471 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.471 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.470 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.470 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.470 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.470 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.469 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.469 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.469 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.469 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.468 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.468 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.467 | |
| 4e6a | 0O9 | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.466 | |
| 3kr6 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.466 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.466 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.465 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.464 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.464 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.464 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.464 | |
| 3rpn | GTX | Glutathione S-transferase kappa 1 | 2.5.1.18 | 0.464 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.464 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1e7a | PFL | Serum albumin | / | 0.463 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.463 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.463 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 3up0 | D7S | aceDAF-12 | / | 0.463 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.462 | |
| 1zdw | FLV | Prenyltransferase | / | 0.462 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.462 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.462 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.462 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.462 | |
| 1osv | CHC | Bile acid receptor | / | 0.461 | |
| 2wpx | ACO | Orf14 | / | 0.461 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.461 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.461 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.461 | |
| 3wix | LC3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.461 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.461 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.461 | |
| 5doz | NDP | JamJ | / | 0.461 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.460 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.460 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.460 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.460 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.459 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.459 | |
| 4apu | A2K | Progesterone receptor | / | 0.459 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.459 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.458 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.458 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.458 | |
| 3tgu | WF3 | Cytochrome b | / | 0.458 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.458 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.458 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.457 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.457 | |
| 4iae | 1DX | Alr2278 protein | / | 0.457 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.457 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.456 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.456 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.456 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4fz6 | 0VG | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.456 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.456 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.456 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.456 | |
| 1tg5 | 645 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.455 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.455 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.455 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.455 | |
| 3dol | GWI | Pol protein | / | 0.455 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.455 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.454 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.454 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.454 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.454 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.454 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 3qly | 55V | Uncharacterized protein | / | 0.454 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.454 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.454 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.454 | |
| 1ikv | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 1t0i | FMN | NAD(P)H-dependent FMN reductase LOT6 | / | 0.453 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.453 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.453 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 3dya | PZL | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.453 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.453 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.453 | |
| 4k4f | K4F | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.453 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.452 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.452 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.452 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.452 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.452 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.452 | |
| 1fko | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.451 | |
| 2bxq | IMN | Serum albumin | / | 0.451 | |
| 2pnu | ENM | Androgen receptor | / | 0.451 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.451 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.451 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.451 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.450 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.450 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.449 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.449 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.449 | |
| 3c6u | M22 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3cse | N22 | Uncharacterized protein | / | 0.449 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.449 | |
| 3q92 | XNB | Ketohexokinase | / | 0.449 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.449 | |
| 4iah | 1DX | Alr2278 protein | / | 0.449 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.449 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.449 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.448 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.448 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.448 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.448 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.448 | |
| 4bub | ADP | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase | / | 0.448 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4ubu | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.448 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.448 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.448 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.448 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.447 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.447 | |
| 3ufn | ROC | Gag-Pol polyprotein | / | 0.447 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.447 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.447 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.446 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.446 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.446 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.446 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.446 | |
| 3qai | XNN | Ketohexokinase | / | 0.446 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.446 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.446 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.446 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.445 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.445 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.445 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.445 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.445 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.445 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.445 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.445 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.445 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.445 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.445 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.445 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.444 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.444 | |
| 1l0l | FMX | Cytochrome b | / | 0.444 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.444 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.444 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
| 3stx | BKA | Methylketone synthase I | / | 0.444 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.444 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.444 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.444 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.443 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1eio | GCH | Gastrotropin | / | 0.443 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1hvi | A77 | Protease | / | 0.443 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.443 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.443 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.443 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.443 | |
| 3b9l | AZZ | Serum albumin | / | 0.443 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3i1f | GCP | Translation initiation factor 2 subunit gamma | / | 0.443 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.443 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.443 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.443 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.443 | |
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.443 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.443 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4n4t | 2GV | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.442 | |
| 1kyo | SMA | Cytochrome b | / | 0.442 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.442 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.442 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.442 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.442 | |
| 3gds | VAL_TYR_TYR_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.442 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.442 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.442 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.442 | |
| 4a2j | AS0 | Progesterone receptor | / | 0.442 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dif | A85 | Gag-Pol polyprotein | / | 0.441 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.441 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1pp9 | SMA | Cytochrome b | / | 0.441 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.441 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.441 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.441 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.441 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 3eel | 53T | Uncharacterized protein | / | 0.441 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.441 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.441 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.441 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.440 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.440 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.440 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.440 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2ops | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 2rl1 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3nxe | 2NC | Protease | / | 0.440 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.440 | |
| 3tfq | 07M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.440 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.440 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.440 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.440 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.440 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.440 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.440 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |