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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2p1t3TNRetinoic acid receptor RXR-alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2p1t3TNRetinoic acid receptor RXR-alpha/1.000
2p1u4TNRetinoic acid receptor RXR-alpha/0.576
1mznBM6Retinoic acid receptor RXR-alpha/0.566
1rdtL79Retinoic acid receptor RXR-alpha/0.558
2p1v5TNRetinoic acid receptor RXR-alpha/0.549
1xiuREARetinoic acid receptor RXR/0.539
4m8e29VRetinoic acid receptor RXR-alpha/0.536
4m8hR4MRetinoic acid receptor RXR-alpha/0.530
3uvvREARetinoic acid receptor RXR-alpha/0.522
3falREARetinoic acid receptor RXR-alpha/0.519
1xlsREARetinoic acid receptor RXR-alpha/0.517
1fbyREARetinoic acid receptor RXR-alpha/0.516
1fm69CRRetinoic acid receptor RXR-alpha/0.516
4k6i9RARetinoic acid receptor RXR-alpha/0.516
3fc6REARetinoic acid receptor RXR-alpha/0.508
1uhlMEIRetinoic acid receptor RXR-beta/0.506
1fm99CRRetinoic acid receptor RXR-alpha/0.492
3oapREARetinoic acid receptor RXR-alpha/0.491
1k749CRRetinoic acid receptor RXR-alpha/0.481
1mvcBM6Retinoic acid receptor RXR-alpha/0.474
1bk0ACVIsopenicillin N synthase1.21.3.10.470
4k4j1O8Retinoic acid receptor RXR-alpha/0.469
3h0a9RARetinoic acid receptor RXR-alpha/0.464
3vtbTKAVitamin D3 receptor/0.463
2aclREARetinoic acid receptor RXR-alpha/0.459
3emlZMAAdenosine receptor A2a/0.455
1qiqACCIsopenicillin N synthase1.21.3.10.454
2z3uCRRCytochrome P450/0.454
2iviACWIsopenicillin N synthase1.21.3.10.453
1hb1OCVIsopenicillin N synthase1.21.3.10.451
2ydvNECAdenosine receptor A2a/0.451
1hb3SCVIsopenicillin N synthase1.21.3.10.450
1rf9DBRCamphor 5-monooxygenase1.14.15.10.450
3zkyWT4Isopenicillin N synthase1.21.3.10.450
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
2y60M8FIsopenicillin N synthase1.21.3.10.447
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.447
4bb3KKAIsopenicillin N synthase1.21.3.10.446
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
5hs1VORLanosterol 14-alpha demethylase/0.443
1jomFFODihydrofolate reductase1.5.1.30.442
1uzwCDHIsopenicillin N synthase1.21.3.10.442
3zoiM2WIsopenicillin N synthase1.21.3.10.442
2vbdV10Isopenicillin N synthase1.21.3.10.441
4dvi2IWTankyrase-12.4.2.300.440