Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2p15EZTEstrogen receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2p15EZTEstrogen receptor/1.000
2g44T3OEstrogen receptor/0.515
4iv21GREstrogen receptor/0.515
4iui1GQEstrogen receptor/0.512
2q70DC8Estrogen receptor/0.506
2yatEEUEstrogen receptor/0.505
4iw8KN3Estrogen receptor/0.502
1zky689Estrogen receptor/0.500
4ivy1GTEstrogen receptor/0.500
2fai459Estrogen receptor/0.497
1rf9DBRCamphor 5-monooxygenase1.14.15.10.492
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.488
1fbyREARetinoic acid receptor RXR-alpha/0.483
4p6wMOFGlucocorticoid receptor/0.482
1bk0ACVIsopenicillin N synthase1.21.3.10.481
3nx4NAPPutative oxidoreductase/0.481
4iarERM5-hydroxytryptamine receptor 1B/0.478
2iviACWIsopenicillin N synthase1.21.3.10.477
4bb3KKAIsopenicillin N synthase1.21.3.10.477
1q5dEPBEpothilone C/D epoxidase1.140.476
1fm69CRRetinoic acid receptor RXR-alpha/0.475
1osvCHCBile acid receptor/0.475
2aclREARetinoic acid receptor RXR-alpha/0.475
3kytHC2Nuclear receptor ROR-gamma/0.475
1x7e244Estrogen receptor/0.474
2pnuENMAndrogen receptor/0.474
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.474
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.473
1re9DSOCamphor 5-monooxygenase1.14.15.10.472
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.472
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.472
4j6dTESCytochrome P450 monooxygenase/0.472
3eta351Insulin receptor2.7.10.10.471
4j6cSTRCytochrome P450 monooxygenase/0.471
1oc1ASVIsopenicillin N synthase1.21.3.10.470
2qe4JJ3Estrogen receptor/0.470
3ds6A17Mitogen-activated protein kinase 14/0.470
3q95ESLEstrogen receptor/0.470
2qgtEEDEstrogen receptor/0.469
4h9614QDihydrofolate reductase1.5.1.30.469
4iaq2GM5-hydroxytryptamine receptor 1B/0.469
1r9oFLPCytochrome P450 2C9/0.468
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.468
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.467
1pkfEPDEpothilone C/D epoxidase1.140.467
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.467
3ol5SAWCamphor 5-monooxygenase1.14.15.10.467
3s41S41Glucokinase2.7.1.20.467
3tubFPUTyrosine-protein kinase SYK2.7.10.20.467
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.467
4pxmESTEstrogen receptor/0.466
2jb4A14Isopenicillin N synthase1.21.3.10.465
4ia3BIVVitamin D3 receptor A/0.465
1iyzNDPProbable quinone oxidoreductase/0.464
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.464
1ykdCMPAdenylate cyclase/0.464
2hb7O1CVitamin D3 receptor/0.464
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.464
3l6jZ90Alr2278 protein/0.464
3uudESTEstrogen receptor/0.464
4r20AERCytochrome P450 family 17 polypeptide 2/0.464
1nq7ARLNuclear receptor ROR-beta/0.463
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.463
3l0lHC3Nuclear receptor ROR-gamma/0.463
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.463
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.463
1m7aMQUDihydrofolate reductase1.5.1.30.462
2w4qCBWProstaglandin reductase 21.3.1.480.462
2z3uCRRCytochrome P450/0.462
4a83DXCMajor pollen allergen Bet v 1-A/0.462
4g1z0VPVitamin D3 receptor A/0.462
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.462
5hyrESTEstrogen receptor/0.462
1trgCB3Thymidylate synthase/0.461
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.461
3uvvREARetinoic acid receptor RXR-alpha/0.461
4j6bPLOCytochrome P450 monooxygenase/0.461
5ab7MLCNonspecific lipid-transfer protein, putative/0.461
1lwlDSOCamphor 5-monooxygenase1.14.15.10.460
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.460
3l034OHEstrogen receptor/0.460
3p6pA6BCamphor 5-monooxygenase1.14.15.10.460
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.460
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
1ezfIN0Squalene synthase2.5.1.210.459
1ie9VDXVitamin D3 receptor/0.459
1k749CRRetinoic acid receptor RXR-alpha/0.459
1w06W05Isopenicillin N synthase1.21.3.10.459
2vcmM11Isopenicillin N synthase1.21.3.10.459
3eigMTXDihydrofolate reductase1.5.1.30.459
3irxUDRGag-Pol polyprotein2.7.7.490.459
3lu8IQXSerum albumin/0.459
3p6oETGCamphor 5-monooxygenase1.14.15.10.459
1g50ESTEstrogen receptor/0.458
3t8xT8XT-cell surface glycoprotein CD1b/0.458
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.458
4ia2BIVVitamin D3 receptor A/0.458
4nb6444Nuclear receptor ROR-gamma/0.458
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.458
1gwrESTEstrogen receptor/0.457
3a1l2CCCytochrome P450/0.457
3bejMUFBile acid receptor/0.457
3p6nDSOCamphor 5-monooxygenase1.14.15.10.457
3zkuHCVIsopenicillin N synthase1.21.3.10.457
3zkyWT4Isopenicillin N synthase1.21.3.10.457
4jbtASDCytochrome P450 monooxygenase/0.457
4jqh1MFAlr2278 protein/0.457
4wa9AXITyrosine-protein kinase ABL12.7.10.20.457
1dajMOTDihydrofolate reductase1.5.1.30.456
1hb1OCVIsopenicillin N synthase1.21.3.10.456
1x7rGENEstrogen receptor/0.456
2b1z17MEstrogen receptor/0.456
2bxoOPBSerum albumin/0.456
2g78REACellular retinoic acid-binding protein 2/0.456
2giuFBREstrogen receptor beta/0.456
2zlaVDBVitamin D3 receptor/0.456
3njoPYVAbscisic acid receptor PYR1/0.456
3p6mDSOCamphor 5-monooxygenase1.14.15.10.456
3qm4PN0Cytochrome P450 2D6/0.456
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.456
4h9753SDihydrofolate reductase1.5.1.30.456
4l9q9TPSerum albumin/0.456
1lriCLRBeta-elicitin cryptogein/0.455
1ppjANYCytochrome b/0.455
2dhfDZFDihydrofolate reductase1.5.1.30.455
2zbaZBATrichothecene 3-O-acetyltransferase/0.455
4a9mP9MBromodomain-containing protein 2/0.455
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.455
4j26ESTEstrogen receptor beta/0.455
1uzwCDHIsopenicillin N synthase1.21.3.10.454
3v9v21LPeroxisome proliferator-activated receptor gamma/0.454
3vtdTKDVitamin D3 receptor/0.454
4b7dQLECytochrome P450 monooxygenase PikC/0.454
4iq71G9Mycocyclosin synthase1.14.21.90.454
4k6i9RARetinoic acid receptor RXR-alpha/0.454
1l2jETCEstrogen receptor beta/0.453
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.453
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4dhyS41Glucokinase2.7.1.20.453
4ia1BIVVitamin D3 receptor A/0.453
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
1hb3SCVIsopenicillin N synthase1.21.3.10.452
1ia3TQ5Dihydrofolate reductase1.5.1.30.452
2hcdBIVVitamin D3 receptor A/0.452
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.452
2vn0TDZCytochrome P450 2C8/0.452
3p9tTCLRepressor/0.452
3tdaPN0Cytochrome P450 2D6/0.452
4ict1EDMycocyclosin synthase1.14.21.90.452
1fm99CRRetinoic acid receptor RXR-alpha/0.451
2po7CHDFerrochelatase, mitochondrial4.99.1.10.451
2y6fM9FIsopenicillin N synthase1.21.3.10.451
3tmz06XCytochrome P450 2B41.14.14.10.451
4g1d0VKVitamin D3 receptor A/0.451
1cbrREACellular retinoic acid-binding protein 1/0.450
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.450
1qjfACSIsopenicillin N synthase1.21.3.10.450
1rdtL79Retinoic acid receptor RXR-alpha/0.450
2w2lNADD-mandelate dehydrogenase/0.450
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3g5hYTTMycocyclosin synthase1.14.21.90.450
3ua506XCytochrome P450 2B61.14.130.450
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.450
4nr42LKCREB-binding protein/0.450
1cd2FOLDihydrofolate reductase1.5.1.30.449
1dgfNDPCatalase1.11.1.60.449
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1qiqACCIsopenicillin N synthase1.21.3.10.449
2lbdREARetinoic acid receptor gamma/0.449
2p1v5TNRetinoic acid receptor RXR-alpha/0.449
2pogWSTEstrogen receptor/0.449
2zb8IMNProstaglandin reductase 21.3.1.480.449
3bfa9ODOdorant binding protein ASP1/0.449
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4jlk1NODeoxycytidine kinase2.7.1.740.449
4nieNBHNuclear receptor ROR-gamma/0.449
4pd6URINucleoside permease/0.449
1fmlRTLRetinol dehydratase/0.448
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.448
2c7xNRBCytochrome P450 monooxygenase PikC/0.448
2hm9TRRDihydrofolate reductase1.5.1.30.448
2k62ITLFatty acid-binding protein, liver/0.448
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.448
3zoiM2WIsopenicillin N synthase1.21.3.10.448
4b4w9L9Bifunctional protein FolD/0.448
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.448
4kbn25UDihydrofolate reductase1.5.1.30.448
5hs1VORLanosterol 14-alpha demethylase/0.448
1kb9SMACytochrome b/0.447
1s19MC9Vitamin D3 receptor/0.447
2nnhREACytochrome P450 2C8/0.447
2wo7ASVIsopenicillin N synthase1.21.3.10.447
3hz5Z64Heat shock protein HSP 90-alpha/0.447
3oapREARetinoic acid receptor RXR-alpha/0.447
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
4ag7COAGlucosamine 6-phosphate N-acetyltransferase/0.447
4dsgFADUncharacterized protein/0.447
4j24ESTEstrogen receptor beta/0.447
4uyf73BBromodomain-containing protein 2/0.447
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1o5rFR9Adenosine deaminase3.5.4.40.446
1s6qTPBGag-Pol polyprotein2.7.7.490.446
1x78244Estrogen receptor beta/0.446
2fszOHTEstrogen receptor beta/0.446
2hasC3OVitamin D3 receptor/0.446
2igyA2TPlasmepsin 2/0.446
2uxpCLMHTH-type transcriptional regulator TtgR/0.446
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.446
4iah1DXAlr2278 protein/0.446
4r21STRCytochrome P450 family 17 polypeptide 2/0.446
3uzcT4EAdenosine receptor A2a/0.446
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
2g5oDRQEstrogen receptor/0.445
2vbpVB1Isopenicillin N synthase1.21.3.10.445
3sls77DDual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
5br4NADLactaldehyde reductase1.1.1.770.445
5dx3ESTEstrogen receptor/0.445
1fm4DXCMajor pollen allergen Bet v 1-L/0.444
1sj0E4DEstrogen receptor/0.444
1uhlMEIRetinoic acid receptor RXR-beta/0.444
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.444
3eem53VUncharacterized protein/0.444
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3p3zP3ZPutative cytochrome P450/0.444
3qlhT27Gag-Pol polyprotein2.7.7.490.444
4japCOAAlpha-pyrone synthesis polyketide synthase-like Pks112.3.10.444
4kak06UDihydrofolate reductase1.5.1.30.444
1blzACVIsopenicillin N synthase1.21.3.10.443
1e26GPBDihydrofolate reductase1.5.1.30.443
1kzjCB3Thymidylate synthase/0.443
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.443
2hw2RFPRifampin ADP-ribosyl transferase/0.443
2i9pNAD3-hydroxyisobutyrate dehydrogenase, mitochondrial1.1.1.310.443
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3cv9VDXVitamin D3 dihydroxylase/0.443
3gc9B45Mitogen-activated protein kinase 112.7.11.240.443
3u8hBHPPhospholipase A2, membrane associated/0.443
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4ez8DHFThymidylate synthase2.1.1.450.443
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
4ia7BIVVitamin D3 receptor A/0.443
4ixeIXEDihydrofolate reductase1.5.1.30.443
4kd79DRDihydrofolate reductase1.5.1.30.443
5bt42LOBromodomain-containing protein 4/0.443
5cmsAPRO-acetyl-ADP-ribose deacetylase/0.443
5k2bZMAAdenosine receptor A2a/0.443
1crbRTLRetinol-binding protein 1/0.442
1fd0254Retinoic acid receptor gamma/0.442
1ia4TQ6Dihydrofolate reductase1.5.1.30.442
1xddAAYIntegrin alpha-L/0.442
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.442
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
3eel53TUncharacterized protein/0.442
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.442
4jlj1NMDeoxycytidine kinase2.7.1.740.442
4o71CPBBromodomain-containing protein 4/0.442
4y8wSTRSteroid 21-hydroxylase/0.442
1klkPMDDihydrofolate reductase1.5.1.30.441
1rd4L08Integrin alpha-L/0.441
1rrmAPRLactaldehyde reductase1.1.1.770.441
1ysx4EBSerum albumin/0.441
2ca0PXICytochrome P450 monooxygenase PikC/0.441
2imkGTXAGAP009194-PA/0.441
2y01Y01Beta-1 adrenergic receptor/0.441
2ydwWSHBromodomain-containing protein 2/0.441
3abaFLICytochrome P450/0.441
3lfeZ84Mitogen-activated protein kinase 14/0.441
3p99LNPLanosterol 14-alpha-demethylase/0.441
4hee14RPeroxisome proliferator-activated receptor gamma/0.441
4ktkKTKCytochrome P450/0.441
4ktl1CQCytochrome P450/0.441
4ucnMYAGlycylpeptide N-tetradecanoyltransferase/0.441
5bp9SAHPutative methyltransferase protein/0.441
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.440
1mznBM6Retinoic acid receptor RXR-alpha/0.440
1ndeMONEstrogen receptor beta/0.440
1qknRALEstrogen receptor beta/0.440
1yb5NAPQuinone oxidoreductase1.6.5.50.440
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.440
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
2rkvZBATrichothecene 3-O-acetyltransferase/0.440
2vbdV10Isopenicillin N synthase1.21.3.10.440
3ibdCPZCytochrome P450 2B61.14.130.440
3stxBKAMethylketone synthase I/0.440
3vt3VDXVitamin D3 receptor/0.440
3vt7VDXVitamin D3 receptor/0.440
3vtcTK3Vitamin D3 receptor/0.440
4dma0L8Estrogen receptor/0.440
4i8vBHFCytochrome P450 1A11.14.14.10.440
4n4t2GVTankyrase-12.4.2.300.440