Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2oxnOANBeta-hexosaminidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2oxnOANBeta-hexosaminidase/1.000
4yau2AMNADPH--cytochrome P450 reductase/0.502
2bpoNAPNADPH--cytochrome P450 reductase/0.500
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.498
5cuqNSCGenome polyprotein/0.491
4y9uNAPNADPH--cytochrome P450 reductase/0.489
4yaw2AMNADPH--cytochrome P450 reductase/0.488
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.485
5jy1NADPutative short-chain dehydrogenase/reductase/0.484
3eblGA4Gibberellin receptor GID1/0.483
4y9rNAPNADPH--cytochrome P450 reductase/0.483
2zevB71Geranylgeranyl pyrophosphate synthase/0.482
2vd7PD2Lysine-specific demethylase 4A1.14.110.481
2w03ADNAcsD/0.481
4y7cNAPNADPH--cytochrome P450 reductase/0.481
2du2FMNLactate oxidase/0.476
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.476
4jxrACOAcetyltransferase/0.476
2bf4NAPNADPH--cytochrome P450 reductase/0.475
4awgCI3Polymerase acidic protein/0.473
4yao2AMNADPH--cytochrome P450 reductase/0.472
1ppjANYCytochrome b/0.469
1i59ANPChemotaxis protein CheA2.7.13.30.468
3ggcH26Hypoxanthine-guanine phosphoribosyltransferase2.4.2.80.468
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
4yal2AMNADPH--cytochrome P450 reductase/0.466
4ybrNAPProbable nicotinate-nucleotide adenylyltransferase2.7.7.180.466
2a7r5GPGMP reductase 2/0.465
3kc12T6Fructose-1,6-bisphosphatase 13.1.3.110.465
4lutDCSAlanine racemase/0.465
2oegUPGUDP-glucose pyrophosphorylase/0.464
4e5h0N8Polymerase acidic protein/0.464
4yaf2AMNADPH--cytochrome P450 reductase/0.464
2gevCOKPantothenate kinase2.7.1.330.463
2w6pOA4Biotin carboxylase6.3.4.140.463
2w6zL21Biotin carboxylase6.3.4.140.463
4a6nFADTetX family tetracycline inactivation enzyme/0.463
3qe2NAPNADPH--cytochrome P450 reductase/0.462
4m2bUPGUDP-glucose pyrophosphorylase/0.462
1cqp803Integrin alpha-L/0.461
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
5d9j0N8Polymerase acidic protein/0.461
1amoNAPNADPH--cytochrome P450 reductase/0.460
2acxANPG protein-coupled receptor kinase 62.7.11.160.460
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.460
1itzTPPTransketolase, chloroplastic2.2.1.10.459
3hazFADBifunctional protein PutA/0.459
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
1ay0TPPTransketolase 12.2.1.10.458
1nzfUPGDNA beta-glucosyltransferase/0.458
1culFOKAdenylate cyclase type 2/0.457
1culFOKAdenylate cyclase type 5/0.457
1jedADPSulfate adenylyltransferase/0.457
2ejvNADL-threonine 3-dehydrogenase/0.457
2oapANPType II secretion system protein (GspE-2)/0.457
2wwjY28Lysine-specific demethylase 4A/0.457
3ed1GA3Gibberellin receptor GID1/0.457
3vjoANPEpidermal growth factor receptor2.7.10.10.457
4mlp2CXCryptochrome-2/0.457
5kgpACOPredicted acetyltransferase/0.457
1kt3RTLRetinol-binding protein 4/0.456
2nnqT4BFatty acid-binding protein, adipocyte/0.456
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.456
3fvlBHKCarboxypeptidase A13.4.17.10.456
3qfsNAPNADPH--cytochrome P450 reductase/0.456
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
3uleC69Actin-related protein 3/0.456
1bwsNDPGDP-L-fucose synthase/0.455
1nzdUPGDNA beta-glucosyltransferase/0.455
1i59ADPChemotaxis protein CheA2.7.13.30.454
1ove358Mitogen-activated protein kinase 14/0.454
1xe55FEPlasmepsin-23.4.23.390.454
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2rc6NAPFerredoxin--NADP reductase/0.454
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.453
1kqwRTLCellular retinol-binding protein type II/0.453
2i7nACOPantothenate kinase 12.7.1.330.453
3iexGMPPurine nucleoside phosphorylase/0.453
4gd40WSLysine-specific demethylase 4A1.14.110.453
4jhz1KVBeta-glucuronidase3.2.1.310.453
4zrnUPGUDP-glucose 4-epimerase, putative/0.453
1fmlRTLRetinol dehydratase/0.452
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.452
2impNAILactaldehyde dehydrogenase1.2.1.220.452
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.452
4bis8HQLysine-specific demethylase 4A1.14.110.452
2v59LZKBiotin carboxylase6.3.4.140.451
3af1GDPPantothenate kinase2.7.1.330.451
1qcjAPTAntiviral protein I3.2.2.220.450
1xjqADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.450
2z4y252Geranylgeranyl pyrophosphate synthase/0.450
3a8wATPProtein kinase C iota type2.7.11.130.450
3v94WYQPhosphodiesterase/0.450
4bfyZVYPantothenate kinase2.7.1.330.450
4iawLIZNeutrophil gelatinase-associated lipocalin/0.450
4lxlPD2Lysine-specific demethylase 4B1.14.110.450
1vyrFMNPentaerythritol tetranitrate reductase/0.449
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.449
1gveNAPAflatoxin B1 aldehyde reductase member 310.448
3ahiHTLProbable phosphoketolase/0.448
3hx4ANPCalmodulin-domain protein kinase 1/0.448
3nf8CDQGag-Pol polyprotein/0.448
3r1rATPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.448
4ww4ADPRuvB-like helicase/0.448
1l8qADPChromosomal replication initiator protein DnaA/0.447
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.447
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.447
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3enkUPGUDP-glucose 4-epimerase/0.447
3h3r14HCollagen type IV alpha-3-binding protein/0.447
3qfcNAPNADPH--cytochrome P450 reductase/0.447
3qftNAPNADPH--cytochrome P450 reductase/0.447
3zc3NAPFerredoxin--NADP reductase1.18.1.20.447
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.446
3h3t16HCollagen type IV alpha-3-binding protein/0.446
3kbz2T4Fructose-1,6-bisphosphatase 13.1.3.110.446
4b99R4LMitogen-activated protein kinase 72.7.11.240.446
1lluNADAlcohol dehydrogenase/0.445
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.445
2flhZEACytokinin-specific binding protein/0.445
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.445
4gk3L87Ephrin type-A receptor 32.7.10.10.445
1kvtUPGUDP-glucose 4-epimerase5.1.3.20.444
1u3cFADCryptochrome-1/0.444
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.444
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.444
3u8hBHPPhospholipase A2, membrane associated/0.444
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.444
1f52ADPGlutamine synthetase6.3.1.20.443
1hncGDNGlutathione S-transferase Mu 22.5.1.180.443
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1rywEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443
2cy0NAPShikimate dehydrogenase (NADP(+))/0.443
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.443
4m2aUPGUDP-glucose pyrophosphorylase/0.443
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.443
1ek5NADUDP-glucose 4-epimerase/0.442
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.442
1uycPU7Heat shock protein HSP 90-alpha/0.442
2iviACWIsopenicillin N synthase1.21.3.10.442
3nmnPYVAbscisic acid receptor PYL1/0.442
3zxvMXIGlutamine synthetase6.3.1.20.442
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.441
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.441
2xf3J01Uncharacterized protein/0.441
2xfsJ01Uncharacterized protein/0.441
3m9vTYDFAD-dependent oxidoreductase/0.441
3zkyWT4Isopenicillin N synthase1.21.3.10.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4i6gFADCryptochrome-2/0.441
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
4m4922YL-lactate dehydrogenase A chain1.1.1.270.441
4qa0SHHHistone deacetylase 83.5.1.980.441
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.440
1z4uPH9Polyprotein/0.440
2ggqTTPDual sugar-1-phosphate nucleotidylyltransferase/0.440
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.440
3h3sH15Collagen type IV alpha-3-binding protein/0.440
4f9fGDPPutative glycosyltransferase/0.440
4gncASORegucalcin3.1.1.170.440
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.440