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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2owfSAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2owfSAHDiphthine synthase/1.000
2ed3SAHDiphthine synthase/0.612
2ejzSAHDiphthine synthase/0.604
1vceSAHDiphthine synthase/0.578
2ed5SAHDiphthine synthase/0.578
2owuSAHDiphthine synthase/0.578
2e08SAHDiphthine synthase/0.575
2ehlSAHDiphthine synthase/0.574
2ejkSAHDiphthine synthase/0.572
2hr8SAHDiphthine synthase/0.564
2p6iSAHDiphthine synthase/0.563
2e07SAHDiphthine synthase/0.562
1wngSAHDiphthine synthase/0.561
2p5fSAHDiphthine synthase/0.561
2emuSAHDiphthine synthase/0.560
2owvSAHDiphthine synthase/0.559
2dekSAHDiphthine synthase/0.558
2p5cSAHDiphthine synthase/0.558
2e8qSAHDiphthine synthase/0.557
2eglSAHDiphthine synthase/0.557
2hutSAHDiphthine synthase/0.556
2dxwSAHDiphthine synthase/0.555
2owkSAHDiphthine synthase/0.555
2p9dSAHDiphthine synthase/0.555
2en5SAHDiphthine synthase/0.553
2el3SAHDiphthine synthase/0.552
2z6rSAHDiphthine synthase/0.552
2eh4SAHDiphthine synthase/0.551
2dv7SAHDiphthine synthase/0.550
2el0SAHDiphthine synthase/0.550
2p6dSAHDiphthine synthase/0.550
2e4nSAHDiphthine synthase/0.549
2eniSAHDiphthine synthase/0.549
2pb4SAHDiphthine synthase/0.549
2eldSAHDiphthine synthase/0.548
2huqSAHDiphthine synthase/0.548
2owgSAHDiphthine synthase/0.548
2huxSAHDiphthine synthase/0.546
2dsiSAHDiphthine synthase/0.545
2dxvSAHDiphthine synthase/0.545
2e16SAHDiphthine synthase/0.545
2e8hSAHDiphthine synthase/0.545
2ek7SAHDiphthine synthase/0.544
2dsgSAHDiphthine synthase/0.543
2egbSAHDiphthine synthase/0.543
2eleSAHDiphthine synthase/0.543
2huvSAHDiphthine synthase/0.543
2ejjSAHDiphthine synthase/0.542
2pcgSAHDiphthine synthase/0.542
2pcmSAHDiphthine synthase/0.542
2p2xSAHDiphthine synthase/0.541
2dv3SAHDiphthine synthase/0.540
2ek2SAHDiphthine synthase/0.540
2e7rSAHDiphthine synthase/0.539
2emrSAHDiphthine synthase/0.539
2e8sSAHDiphthine synthase/0.537
2dxxSAHDiphthine synthase/0.536
2e15SAHDiphthine synthase/0.536
2pcaSAHDiphthine synthase/0.535
2pchSAHDiphthine synthase/0.535
2egsSAHDiphthine synthase/0.534
2ek4SAHDiphthine synthase/0.534
2pb5SAHDiphthine synthase/0.534
2dv4SAHDiphthine synthase/0.533
2dshSAHDiphthine synthase/0.532
2p6kSAHDiphthine synthase/0.532
2eeqSAHDiphthine synthase/0.530
2eh2SAHDiphthine synthase/0.530
2ek3SAHDiphthine synthase/0.529
2pb6SAHDiphthine synthase/0.529
2pckSAHDiphthine synthase/0.529
2eh5SAHDiphthine synthase/0.527
2dv5SAHDiphthine synthase/0.524
2e17SAHDiphthine synthase/0.524
2p6lSAHDiphthine synthase/0.518
2pciSAHDiphthine synthase/0.516
2ekaSAHDiphthine synthase/0.509
2e8rSAHDiphthine synthase/0.504
1ohhANPATP synthase subunit alpha, mitochondrial/0.478
1ohhANPATP synthase subunit beta, mitochondrial3.6.3.140.478
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.477
1e1qANPATP synthase subunit alpha, mitochondrial/0.470
1e1qANPATP synthase subunit beta, mitochondrial3.6.3.140.470
3tjzGNPADP-ribosylation factor 1/0.469
1xe55FEPlasmepsin-23.4.23.390.465
1e79ATPATP synthase subunit alpha, mitochondrial/0.463
1e79ATPATP synthase subunit beta, mitochondrial3.6.3.140.463
3ig6438Urokinase-type plasminogen activator3.4.21.730.463
1h8hATPATP synthase subunit alpha, mitochondrial/0.462
1h8hATPATP synthase subunit beta, mitochondrial3.6.3.140.462
4asuADPATP synthase subunit alpha, mitochondrial/0.462
4g3jVNTLanosterol 14-alpha-demethylase/0.462
4g7gVFVLanosterol 14-alpha-demethylase/0.461
1w6hTITPlasmepsin-23.4.23.390.457
1lbcCYZGlutamate receptor 2/0.456
1w0kADPATP synthase subunit alpha, mitochondrial/0.455
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.455
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.455
4frkDWDBeta-secretase 13.4.23.460.454
1xddAAYIntegrin alpha-L/0.453
2a94AP0L-lactate dehydrogenase1.1.1.270.453
2uxoTACHTH-type transcriptional regulator TtgR/0.453
3p3zP3ZPutative cytochrome P450/0.453
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
4bfzZVZPantothenate kinase2.7.1.330.451
1a2nTETUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.449
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.449
3gw9VNILanosterol 14-alpha-demethylase/0.449
1rneC60Renin3.4.23.150.447
1t2cNAIL-lactate dehydrogenase1.1.1.270.446
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.445
2gjlFMNNitronate monooxygenase1.13.12.160.445
3a3gDLZLumazine protein/0.445
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.443
1tqf32PBeta-secretase 13.4.23.460.442
4bfxZVXPantothenate kinase2.7.1.330.442
4m83ERYOleandomycin glycosyltransferase2.4.10.442
2rlcCHDCholoylglycine hydrolase3.5.1.240.441
2xhd7T9Glutamate receptor 2/0.441
3in6FMNUncharacterized protein/0.440
4bfwZVWPantothenate kinase2.7.1.330.440
4h3j10WBeta-secretase 13.4.23.460.440
5c1mCLRMu-type opioid receptor/0.440