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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2op9WR1Orf1ab polyprotein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2op9WR1Orf1ab polyprotein/1.000
3v3m0ENReplicase polyprotein 1a3.4.19.120.565
2gz7D3FOrf1a polyprotein/0.555
2qiqCYVReplicase polyprotein 1ab/0.521
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.486
2gz8F3FOrf1a polyprotein/0.474
2ebaFADPutative glutaryl-CoA dehydrogenase/0.471
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.468
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
1k6cMK1Gag-Pol polyprotein3.4.23.160.465
3pqbVGPPutative oxidoreductase/0.464
3omuIBDHeat shock protein 83/0.462
4bfvZVVPantothenate kinase2.7.1.330.461
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.460
4g3jVNTLanosterol 14-alpha-demethylase/0.460
1e3eNAIAlcohol dehydrogenase 41.1.1.10.459
2uxoTACHTH-type transcriptional regulator TtgR/0.459
2a5kAZPReplicase polyprotein 1ab3.4.220.458
4g7gVFVLanosterol 14-alpha-demethylase/0.458
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
3d4pNADL-lactate dehydrogenase 11.1.1.270.456
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.456
1mjbACOHistone acetyltransferase ESA1/0.455
3gw9VNILanosterol 14-alpha-demethylase/0.455
1mp0NADAlcohol dehydrogenase class-31.1.1.10.454
3toxNAPPutative oxidoreductase/0.453
1dhjMTXDihydrofolate reductase1.5.1.30.452
5dp2NAPCurF/0.452
5jscFADPutative acyl-CoA dehydrogenase/0.452
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.451
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
4nbwNADShort-chain dehydrogenase/reductase SDR/0.450
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.449
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.449
1jkx138Phosphoribosylglycinamide formyltransferase/0.448
1k6tXN1Gag-Pol polyprotein3.4.23.160.448
1xe55FEPlasmepsin-23.4.23.390.448
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.448
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.448
3ijoB4DGlutamate receptor 2/0.446
4gl4NAIAlcohol dehydrogenase class-3/0.446
2ejjSAHDiphthine synthase/0.445
4bfwZVWPantothenate kinase2.7.1.330.445
2ejzSAHDiphthine synthase/0.444
2ikuLIYRenin3.4.23.150.444
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.444
1jg0DDTThymidylate synthase/0.443
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2g20L1ARenin3.4.23.150.443
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.443
2z3lPHE_ARG_TYR_LEU_GLYLeucyl/phenylalanyl-tRNA--protein transferase2.3.2.60.442
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.442
1lf2R37Plasmepsin-23.4.23.390.441
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.441
2gtbAZPOrf1ab polyprotein/0.441
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.441
4bfxZVXPantothenate kinase2.7.1.330.441
1dhiMTXDihydrofolate reductase1.5.1.30.440
1geeNADGlucose 1-dehydrogenase1.1.1.470.440
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2g1r3IGRenin3.4.23.150.440
2hk9NAPShikimate dehydrogenase (NADP(+))/0.440
2ou2ACOHistone acetyltransferase KAT5/0.440
2pckSAHDiphthine synthase/0.440