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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2op07PCEnoyl-ACP reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2op07PCEnoyl-ACP reductase/1.000
1nnuTCTEnoyl-ACP reductase/0.690
2ol4JPNEnoyl-ACP reductase/0.598
3f4bTCLEnoyl-acyl carrier protein reductase/0.582
1zxlJP1Enoyl-ACP reductase/0.577
1nhwTCCEnoyl-ACP reductase/0.574
4igeCHJEnoyl-acyl carrier reductase/0.574
3lsyFT0Enoyl-ACP reductase/0.573
3lt2FT3Enoyl-ACP reductase/0.572
1zsnTN2Enoyl-ACP reductase/0.568
3nj8NJ8Enoyl-acyl carrier reductase/0.566
1uh5TCLEnoyl-ACP reductase/0.565
2foiJPAEnoyl-acyl carrier reductase/0.560
1nhgTCLEnoyl-ACP reductase/0.543
2o2yTCLEnoyl-ACP reductase/0.542
3lt1FT2Enoyl-ACP reductase/0.542
3lt0FT1Enoyl-ACP reductase/0.540
3am3TCLEnoyl-ACP reductase/0.536
3am4FT1Enoyl-ACP reductase/0.536
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.534
2o2sTCLEnoyl-acyl carrier reductase/0.529
1zw1TN5Enoyl-ACP reductase/0.520
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.515
2nq8ZIDEnoyl-ACP reductase/0.514
3am5TCLEnoyl-ACP reductase/0.499
3owaFADAcyl-CoA dehydrogenase/0.491
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.489
3nrcTCLEnoyl-[acyl-carrier-protein] reductase [NADH]/0.486
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.482
5e7oMGDDMSO reductase family type II enzyme, molybdopterin subunit/0.478
1yobFMNFlavodoxin 2/0.477
2z1qFADAcyl-CoA dehydrogenase/0.477
1vrwNAIEnoyl-ACP reductase/0.473
1blzACVIsopenicillin N synthase1.21.3.10.472
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.471
1n83CLRNuclear receptor ROR-alpha/0.470
1re9DSOCamphor 5-monooxygenase1.14.15.10.470
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
2zl9VDAVitamin D3 receptor/0.470
4g2h0VQVitamin D3 receptor A/0.470
4q0a4OAVitamin D3 receptor A/0.470
3w8dNAD3-hydroxybutyrate dehydrogenase/0.469
2bxqIMNSerum albumin/0.468
4gevCB3Thymidylate synthase/0.468
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
2gpjFADSiderophore-interacting protein/0.467
2hcdBIVVitamin D3 receptor A/0.467
1tlcF89Thymidylate synthase/0.466
2vqoTFGHistone deacetylase 43.5.1.980.466
3fx4FX4Alcohol dehydrogenase [NADP(+)]1.1.1.20.466
1txiTX5Vitamin D3 receptor/0.465
3lqfNADGalactitol dehydrogenase/0.465
4ixc1JDGlucokinase2.7.1.20.465
3vt5YI2Vitamin D3 receptor/0.464
3w0hW12Vitamin D3 receptor/0.464
2c29NAPDihydroflavonol 4-reductase/0.463
4dc0NDPPutative ketoacyl reductase1.3.10.463
4g1y0VOVitamin D3 receptor A/0.463
4iwv1J9Glucokinase2.7.1.20.463
5hs1VORLanosterol 14-alpha demethylase/0.463
2j9lATPH(+)/Cl(-) exchange transporter 5/0.462
3gkjHC3Niemann-Pick C1 protein/0.462
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.461
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
3a783EVVitamin D3 receptor/0.461
3w2eNADNADH-cytochrome b5 reductase 31.6.2.20.461
4isf1FXGlucokinase2.7.1.20.461
5cb3APRO-acetyl-ADP-ribose deacetylase/0.461
1hk5T44Serum albumin/0.460
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
2o4rVD5Vitamin D3 receptor/0.460
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
1d7oTCLEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.458
3b9lAZZSerum albumin/0.458
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
1hvyD16Thymidylate synthase2.1.1.450.457
1fmjRTLRetinol dehydratase/0.456
1s0xC3SNuclear receptor ROR-alpha/0.456
4enhFVXCholesterol 24-hydroxylase/0.456
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.456
1mczRMNBenzoylformate decarboxylase4.1.1.70.455
2cy2ACOProbable acetyltransferase/0.455
2uzfCAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.455
3bg7FADPyranose 2-oxidase/0.455
3up0D7SaceDAF-12/0.455
3vev0H4Glucokinase2.7.1.20.455
4fogC2FThymidylate synthase ThyA/0.455
4jln18VDeoxycytidine kinase2.7.1.740.455
1ie8KH1Vitamin D3 receptor/0.454
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
2o7pNAPRiboflavin biosynthesis protein RibD/0.454
2zynBCDPeriplasmic binding protein/0.454
3p3zP3ZPutative cytochrome P450/0.454
4dhyS41Glucokinase2.7.1.20.454
4g1z0VPVitamin D3 receptor A/0.454
4j6dTESCytochrome P450 monooxygenase/0.454
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.454
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.453
1suiFRECaffeoyl-CoA O-methyltransferase2.1.1.1040.453
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2zlaVDBVitamin D3 receptor/0.453
3bgxMEFThymidylate synthase/0.453
4itfTFYVitamin D3 receptor/0.453
1s19MC9Vitamin D3 receptor/0.452
1w06W05Isopenicillin N synthase1.21.3.10.452
2jh0701Prothrombin3.4.21.50.452
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.452
3e2sFADBifunctional protein PutA1.5.5.20.452
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.452
4rujVDXVitamin D3 receptor A/0.452
1dkfBMSRetinoic acid receptor alpha/0.451
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
3to3ATPPetrobactin biosynthesis protein AsbB/0.451
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.451
4knzCB3Thymidylate synthase/0.451
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
3p6mDSOCamphor 5-monooxygenase1.14.15.10.450
4iarERM5-hydroxytryptamine receptor 1B/0.450
1oc1ASVIsopenicillin N synthase1.21.3.10.449
2hb8MVDVitamin D3 receptor/0.449
2ptfFMNUncharacterized protein MTH_863/0.449
3cnjFADCholesterol oxidase1.1.3.60.449
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3p2oNADBifunctional protein FolD/0.449
4g1d0VKVitamin D3 receptor A/0.449
4iteTEYVitamin D3 receptor/0.449
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.449
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1pkfEPDEpothilone C/D epoxidase1.140.448
1rkhVD2Vitamin D3 receptor/0.448
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2xveFADPutative flavin-containing monooxygenase/0.448
3h3sH15Collagen type IV alpha-3-binding protein/0.448
3zkyWT4Isopenicillin N synthase1.21.3.10.448
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.448
4ma628EAra h 8 allergen/0.448
5dp2NAPCurF/0.448
1kceCB3Thymidylate synthase/0.447
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.447
3h1vTK1Glucokinase2.7.1.20.447
3ijdC2FMethylenetetrahydrofolate reductase/0.447
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3pqbVGPPutative oxidoreductase/0.447
3q0uLL3HTH-type transcriptional regulator EthR/0.447
3sf6FDAGlutaryl-CoA dehydrogenase/0.447
4bquCLRJapanin/0.447
4nmbFADBifunctional protein PutA/0.447
4xwrFADCholesterol oxidase1.1.3.60.447
5cp4CAMCamphor 5-monooxygenase1.14.15.10.447
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.446
1poxFADPyruvate oxidase1.2.3.30.446
2mscGDPMHC class I alpha chain/0.446
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.446
3gkiCLRNiemann-Pick C1 protein/0.446
3q3cNADNAD-dependent L-serine dehydrogenase/0.446
3w0c6DSVitamin D3 receptor/0.446
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4g20484Vitamin D3 receptor A/0.446
4jq3NAPAldo-keto reductase family 1 member C2/0.446
4jtqNAPAldo-keto reductase family 1 member C2/0.446
4k9yK9YFocal adhesion kinase 12.7.10.20.446
5kf1ACOPredicted acetyltransferase/0.446
1b2lNDCAlcohol dehydrogenase1.1.1.10.445
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.445
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1ybgTAVUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
2dvlFADAcyl-CoA dehydrogenase/0.445
2o4jVD4Vitamin D3 receptor/0.445
2xgs44PUncharacterized protein/0.445
3gdsVAL_TYR_TYR_PHESerine endoprotease DegS3.4.21.1070.445
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.445
4eh9IRGMitogen-activated protein kinase 14/0.445
4o1mNADEnoyl-acyl carrier reductase/0.445
4q71FADBifunctional protein PutA/0.445
1e1lFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.444
1eioGCHGastrotropin/0.444
1fmlRTLRetinol dehydratase/0.444
1ie9VDXVitamin D3 receptor/0.444
1tj1FADBifunctional protein PutA1.5.5.20.444
2xpuTDCTetracycline repressor protein class D/0.444
3slkNDPPolyketide synthase extender module 2/0.444
3tk3CPZCytochrome P450 2B41.14.14.10.444
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.444
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.444
4ead0NPThymidine phosphorylase2.4.2.40.444
4tyqAP5Adenylate kinase/0.444
4xwtU5PRibonuclease J/0.444
1b4vFADCholesterol oxidase1.1.3.60.443
1db1VDXVitamin D3 receptor/0.443
1osvCHCBile acid receptor/0.443
2bu9HFVIsopenicillin N synthase1.21.3.10.443
2gpvOHTEstrogen-related receptor gamma/0.443
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3cobADPKinesin heavy chain-like protein/0.443
3lu8IQXSerum albumin/0.443
3mdmFJZCholesterol 24-hydroxylase/0.443
3p6nDSOCamphor 5-monooxygenase1.14.15.10.443
3qly55VUncharacterized protein/0.443
3rgaILDEpoxide hydrolase LasB5.5.10.443
3vrtYS2Vitamin D3 receptor/0.443
3vt8YI3Vitamin D3 receptor/0.443
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.443
3emlZMAAdenosine receptor A2a/0.443
1cbrREACellular retinoic acid-binding protein 1/0.442
1q4xG24Thyroid hormone receptor beta/0.442
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.442
1y4lSVRBasic phospholipase A2 homolog 2/0.442
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.442
2feuCAMCamphor 5-monooxygenase1.14.15.10.442
2hasC3OVitamin D3 receptor/0.442
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2rc6NAPFerredoxin--NADP reductase/0.442
2x9dITCTetracycline repressor protein class D/0.442
2y6fM9FIsopenicillin N synthase1.21.3.10.442
3gwfFADCyclohexanone monooxygenase/0.442
3r354CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.442
3w0yDS4Vitamin D3 receptor/0.442
4q73FADBifunctional protein PutA/0.442
1gjrNAPFerredoxin--NADP reductase1.18.1.20.441
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.441
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.441
1jpaANPEphrin type-B receptor 22.7.10.10.441
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.441
1pz1NAPGeneral stress protein 69/0.441
1v4sMRKGlucokinase2.7.1.20.441
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.441
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2fj1CTCTetracycline repressor protein class D/0.441
2vbpVB1Isopenicillin N synthase1.21.3.10.441
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3lpfZ77Beta-glucuronidase3.2.1.310.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4boeCLRJapanin/0.441
4j6cSTRCytochrome P450 monooxygenase/0.441
4l9kEHFSerum albumin/0.441
4mzuCOAWxcM-like protein/0.441
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.441
4r20AERCytochrome P450 family 17 polypeptide 2/0.441
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3pwhZMAAdenosine receptor A2a/0.441
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1s3uTQDDihydrofolate reductase1.5.1.30.440
1tsdF89Thymidylate synthase/0.440
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.440
2uxoTACHTH-type transcriptional regulator TtgR/0.440
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.440
3pvcFADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.440
3vtbTKAVitamin D3 receptor/0.440
3w5p4OAVitamin D3 receptor/0.440
4a32MYAGlycylpeptide N-tetradecanoyltransferase/0.440
4fhh0U3Vitamin D3 receptor A/0.440
4h2dFMNNADPH-dependent diflavin oxidoreductase 1/0.440
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.440
4l8u9AZSerum albumin/0.440
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4xxgFADCholesterol oxidase1.1.3.60.440