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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2olrATPPhosphoenolpyruvate carboxykinase (ATP)

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2olrATPPhosphoenolpyruvate carboxykinase (ATP)/1.000
2olqATPPhosphoenolpyruvate carboxykinase (ATP)/0.636
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/0.626
1ytmATPPhosphoenolpyruvate carboxykinase (ATP)/0.572
1aylATPPhosphoenolpyruvate carboxykinase (ATP)/0.562
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.532
1aq2ATPPhosphoenolpyruvate carboxykinase (ATP)/0.523
3t1tGDPProbable gliding protein mglA/0.501
2ql6ADPNicotinamide riboside kinase 1/0.491
3nbzGTPGTP-binding nuclear protein Ran/0.489
1ptjSNDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.480
3pcrGTPADP-ribosylation factor 6/0.479
1esvLARActin, alpha skeletal muscle/0.476
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.476
3f3sNADLambda-crystallin homolog/0.473
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.471
2ylrNAPPhenylacetone monooxygenase1.14.13.920.471
3tjzGNPADP-ribosylation factor 1/0.465
3cisATPUniversal stress protein Rv2623/0.463
5k5zANPUncharacterized protein/0.462
1p9wANPType II secretion system protein E/0.461
5jlaNADPutative short-chain dehydrogenase/reductase/0.460
2bn4NAPNADPH--cytochrome P450 reductase/0.458
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.457
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.457
4wxlBB2Peptide deformylase/0.457
2oapANPType II secretion system protein (GspE-2)/0.456
3ibqATPPyridoxal kinase/0.456
4e07ACPPlasmid partitioning protein ParF/0.456
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.456
4lnkADPGlutamine synthetase6.3.1.20.456
4n9iPCGCatabolite expression activator/0.455
1iqrFADDeoxyribodipyrimidine photo-lyase4.1.99.30.454
3o3pGDDGlycosyl transferase, family 2/0.454
4dieC5PCytidylate kinase/0.454
4uj5GNPRas-related protein Rab-11A/0.453
3hyoADPPyridoxal kinase/0.452
4dpwAGSMevalonate diphosphate decarboxylase/0.452
1yb5NAPQuinone oxidoreductase1.6.5.50.451
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.451
1i3nUD1UDP-glucose 4-epimerase/0.450
1bygSTUTyrosine-protein kinase CSK/0.449
1orrCDPCDP-paratose 2-epimerase/0.449
4ipw1G7Mycocyclosin synthase1.14.21.90.449
4hwkNAPSepiapterin reductase1.1.1.1530.448
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.448
2fy4COACholine O-acetyltransferase2.3.1.60.447
2x7hPFNProstaglandin reductase 310.447
3oq6NAJAlcohol dehydrogenase E chain1.1.1.10.447
4ohvANPProtein clpf-1/0.447
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.446
4d5gFADCyclohexane-1,2-dione hydrolase3.7.1.110.446
1i3mUD1UDP-glucose 4-epimerase/0.445
1xddAAYIntegrin alpha-L/0.445
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.445
5ftcADPTPR domain protein/0.445
1lrjUD1UDP-glucose 4-epimerase5.1.3.20.444
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.444
2rc3NADCBS domain/0.444
3r9iADPSeptum site-determining protein MinD/0.444
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.444
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1p3jAP5Adenylate kinase/0.443
4j7uNAPSepiapterin reductase1.1.1.1530.443
1w0kADPATP synthase subunit alpha, mitochondrial/0.442
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.442
2j5xGSPADP-ribosylation factor 6/0.442
3enkUPGUDP-glucose 4-epimerase/0.442
4y8vADPAcyl-CoA synthetase (NDP forming)/0.442
1h47C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.441
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.441
2oo5TXDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
2y0mACOHistone acetyltransferase KAT8/0.441
3af1GDPPantothenate kinase2.7.1.330.441
3ea0ATPATPase, ParA family/0.441
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.441
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.441
1hzjUD1UDP-glucose 4-epimerase/0.440
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.440
1v9aSAHUncharacterized protein/0.440
1zrzBI1Protein kinase C iota type2.7.11.130.440
3c15GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.440
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.440