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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ojj82AMitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ojj82AMitogen-activated protein kinase 12.7.11.241.000
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.564
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.550
4gt3ATPMitogen-activated protein kinase 12.7.11.240.547
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.530
4s33ANPMitogen-activated protein kinase 12.7.11.240.506
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
4ic7ANPMitogen-activated protein kinase 72.7.11.240.499
3i60E86Mitogen-activated protein kinase 12.7.11.240.497
4fv6E57Mitogen-activated protein kinase 12.7.11.240.494
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.490
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.489
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.487
3c4xATPRhodopsin kinase/0.483
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.477
4l9i8PRRhodopsin kinase/0.475
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.475
4nifANPMitogen-activated protein kinase 12.7.11.240.473
4h3qANPMitogen-activated protein kinase 12.7.11.240.470
2yaaATPDeath-associated protein kinase 2/0.469
4qnyANPMitogen activated protein kinase, putative/0.468
4aguD15Cyclin-dependent kinase-like 1/0.467
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.461
3c4wATPRhodopsin kinase/0.460
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4s34ANPMitogen-activated protein kinase 12.7.11.240.456
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.455
4bcmT7ZCyclin-dependent kinase 22.7.11.220.455
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.454
4fmqANPMitogen-activated protein kinase 12.7.11.240.453
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.452
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4fv9E71Mitogen-activated protein kinase 12.7.11.240.452
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3qc9ADPRhodopsin kinase/0.451
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.449
5av2KMPDeath-associated protein kinase 12.7.11.10.449
4c3pACPAurora kinase A2.7.11.10.448
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.447
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.446
2j0lANPFocal adhesion kinase 12.7.10.20.445
3c4zADPRhodopsin kinase/0.445
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1qmzATPCyclin-dependent kinase 22.7.11.220.443
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.443
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
5ap7SVEDual specificity protein kinase TTK2.7.12.10.440