Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 1.000 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.565 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.558 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.553 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.551 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.546 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.540 | |
| 4tyj | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.536 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.531 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.531 | |
| 4qrc | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.528 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.527 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.527 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.525 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.524 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.521 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.521 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.518 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.518 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.515 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.512 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.510 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.510 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.509 | |
| 4agc | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.509 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.508 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.507 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.506 | |
| 3b2w | 9NH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.504 | |
| 2osc | MUH | Angiopoietin-1 receptor | 2.7.10.1 | 0.502 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.502 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.498 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.498 | |
| 4ag8 | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.498 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.497 | |
| 3vw8 | DF6 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.497 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.496 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.496 | |
| 2qu5 | 276 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.495 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.495 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.495 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.494 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.493 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.492 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.492 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.491 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.490 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.490 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.489 | |
| 2zv9 | PP2 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.488 | |
| 3qri | 919 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.488 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.488 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.487 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.486 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.485 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.483 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.482 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.482 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.482 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.482 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.481 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.480 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.479 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.478 | |
| 4uxq | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.478 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.478 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.477 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.477 | |
| 3cjf | SAV | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.476 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 3fzt | 4JZ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.475 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 0.474 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.474 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.473 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.472 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.472 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.472 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.471 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.471 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.471 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.471 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.471 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2py3 | ACP | Fibroblast growth factor receptor 2 | / | 0.470 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.469 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.469 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.469 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.469 | |
| 2fgi | PD1 | Fibroblast growth factor receptor 1 | / | 0.468 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.468 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.467 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.467 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.467 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.466 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.466 | |
| 2vx1 | 7X8 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.466 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.466 | |
| 3h1j | SMA | Cytochrome b | / | 0.466 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 3vry | B43 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.466 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.466 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.466 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.465 | |
| 2xir | 00J | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.465 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.465 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.465 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.464 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.463 | |
| 2buj | STU | Serine/threonine-protein kinase 16 | / | 0.463 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.463 | |
| 3l70 | JZV | Cytochrome b | / | 0.463 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.463 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.463 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.462 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.462 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.461 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.461 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.461 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.461 | |
| 2yix | YIX | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3w2c | N15 | Aurora kinase A | 2.7.11.1 | 0.461 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.461 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.461 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.461 | |
| 1mj3 | HXC | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.460 | |
| 1y6b | AAX | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.460 | |
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.460 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.460 | |
| 1qpe | PP2 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.459 | |
| 2i1m | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.459 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.459 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.459 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.459 | |
| 3hp5 | 52P | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 3tam | M06 | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.459 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.459 | |
| 4mxy | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.459 | |
| 4mxz | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.459 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.459 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.458 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.458 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.458 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.458 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.458 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.457 | |
| 1wbw | LI4 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.457 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.457 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3dle | GFA | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 3sfi | 3SF | HTH-type transcriptional regulator EthR | / | 0.457 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.457 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3g0f | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.456 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.456 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.456 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.456 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 4lgh | 0JN | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1rt2 | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.454 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.454 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.453 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.453 | |
| 3ac5 | KZM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.453 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.452 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.452 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.452 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.452 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.452 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.452 | |
| 1ep4 | S11 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.451 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.450 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.450 | |
| 3q0v | LL4 | HTH-type transcriptional regulator EthR | / | 0.450 | |
| 3qlf | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.450 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.450 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.450 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.450 | |
| 1s1v | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.449 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.449 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.449 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.449 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.449 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.449 | |
| 4id5 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.449 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.448 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.448 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.448 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.448 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.448 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 1nue | GDP | Nucleoside diphosphate kinase B | 2.7.4.6 | 0.447 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.447 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.447 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.447 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.447 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.447 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.447 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.447 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4i2q | 1BT | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 4imt | 1EW | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.447 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.446 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.446 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.446 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.446 | |
| 3dya | PZL | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3t9i | 3T9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.446 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.446 | |
| 4g1q | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.446 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1q4l | 679 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.445 | |
| 1qvn | FRI | Interleukin-2 | / | 0.445 | |
| 1sqv | UHD | Cytochrome b | / | 0.445 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.445 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.445 | |
| 4ftc | H6K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4ftl | H0K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4oav | ACP | 2-5A-dependent ribonuclease | 3.1.26 | 0.445 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.444 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3t19 | 5MA | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.444 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.443 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.443 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.443 | |
| 2xf0 | 4UB | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2xnn | 430 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.443 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.443 | |
| 3p9t | TCL | Repressor | / | 0.443 | |
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.443 | |
| 4ct1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.443 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.443 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.443 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.442 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2vgp | AD6 | Aurora kinase B-A | 2.7.11.1 | 0.442 | |
| 3g0e | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.442 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.442 | |
| 3uvq | FS8 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.442 | |
| 4i7f | NVE | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.441 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.441 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.441 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.441 | |
| 3c5u | P41 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.441 | |
| 3dej | RXC | Caspase-3 | 3.4.22.56 | 0.441 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3lfs | A07 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.441 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.441 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.441 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.441 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.441 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.440 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.440 | |
| 2fvd | LIA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 2xyn | VX6 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.440 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.440 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3ngu | ADP | Nucleoside diphosphate kinase | / | 0.440 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.440 | |
| 3tgu | WF3 | Cytochrome b | / | 0.440 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.440 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
| 4fog | C2F | Thymidylate synthase ThyA | / | 0.440 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.440 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4tqq | UQ1 | Reaction center protein L chain | / | 0.440 | |
| 4xli | 1N1 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.440 | |
| 5amn | DTQ | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.440 | |
| 5doz | NDP | JamJ | / | 0.440 |