sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ogy | C2F | 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase | 2.1.1.258 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ogy | C2F | 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase | 2.1.1.258 | 1.000 | |
| 2e7f | C2F | 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase | 2.1.1.258 | 0.563 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.476 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.457 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.456 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.453 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.451 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.451 | |
| 5dp2 | NAP | CurF | / | 0.450 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.449 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.448 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.448 | |
| 5da9 | AGS | Uncharacterized protein | / | 0.447 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.446 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.444 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.444 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.441 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.441 | |
| 4z0g | 5GP | Inosine-5'-monophosphate dehydrogenase | / | 0.441 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.440 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.440 |