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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2objVRVSerine/threonine-protein kinase pim-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2objVRVSerine/threonine-protein kinase pim-12.7.11.11.000
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.658
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.607
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.598
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.597
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.589
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.571
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.569
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.569
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.555
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.548
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.547
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.546
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.546
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.539
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.537
2ckeIQUDeath-associated protein kinase 2/0.535
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.533
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.531
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.531
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.528
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.521
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.520
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.520
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.516
1jklANPDeath-associated protein kinase 12.7.11.10.514
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.511
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.511
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.511
2ijmADPFocal adhesion kinase 12.7.10.20.509
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.508
3bqr4RBDeath-associated protein kinase 3/0.507
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.507
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.507
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.506
3umw596Serine/threonine-protein kinase pim-12.7.11.10.506
5av2KMPDeath-associated protein kinase 12.7.11.10.506
1xjdSTUProtein kinase C theta type2.7.11.130.505
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.505
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.504
4ic7ANPMitogen-activated protein kinase 72.7.11.240.503
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.503
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.500
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.500
5cvfATPCasein kinase II subunit alpha2.7.11.10.500
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.499
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.499
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.499
4dgnLU2Casein kinase II subunit alpha2.7.11.10.499
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.497
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.496
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.496
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.494
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.494
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.494
1wvxBD4Death-associated protein kinase 12.7.11.10.492
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.492
3zh8C58Protein kinase C iota type2.7.11.130.492
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.491
5av3KMPDeath-associated protein kinase 12.7.11.10.491
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.490
4gmy0X5Tyrosine-protein kinase JAK2/0.490
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.489
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.488
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.487
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.487
3lltANPProtein serine/threonine kinase-1/0.487
3nynSGVG protein-coupled receptor kinase 62.7.11.160.487
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.487
3q9xEMOCasein kinase II subunit alpha2.7.11.10.486
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
4hvi19STyrosine-protein kinase JAK32.7.10.20.485
2j0m4STFocal adhesion kinase 12.7.10.20.483
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.483
3t8oATPRhodopsin kinase/0.483
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.483
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.483
5auwQUEDeath-associated protein kinase 12.7.11.10.483
2yaaATPDeath-associated protein kinase 2/0.482
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.482
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.481
4xlvACPInsulin receptor2.7.10.10.481
1aq1STUCyclin-dependent kinase 22.7.11.220.480
3gubGUBDeath-associated protein kinase 12.7.11.10.480
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.480
2c7xNRBCytochrome P450 monooxygenase PikC/0.478
1pkdUCNCyclin-dependent kinase 22.7.11.220.477
5auvAGIDeath-associated protein kinase 12.7.11.10.477
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.476
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.475
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.475
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.475
3uyt0CKCasein kinase I isoform delta2.7.11.10.475
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.475
2uzbC75Cyclin-dependent kinase 22.7.11.220.474
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.474
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.474
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.474
4j95ACPFibroblast growth factor receptor 2/0.473
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.472
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.471
3oroAGSSerine/threonine protein kinase/0.471
3w2sW2REpidermal growth factor receptor2.7.10.10.471
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4j99ACPFibroblast growth factor receptor 2/0.471
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.470
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.470
2vu3LZECyclin-dependent kinase 22.7.11.220.470
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.470
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.469
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.469
3u4uLNHCasein kinase II subunit alpha2.7.11.10.469
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.469
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.469
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.468
3i60E86Mitogen-activated protein kinase 12.7.11.240.468
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.468
1m2pHNACasein kinase II subunit alpha2.7.11.10.467
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.467
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.467
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.467
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.467
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.467
3gu6ADPDeath-associated protein kinase 12.7.11.10.467
4ez50RSCyclin-dependent kinase 62.7.11.220.467
4grb0XGCasein kinase II subunit alpha2.7.11.10.467
4yuqKS1Calmodulin-like domain protein kinase/0.467
3c4xATPRhodopsin kinase/0.466
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.466
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.466
4erwSTUCyclin-dependent kinase 22.7.11.220.466
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.466
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.466
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.465
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2w17I19Cyclin-dependent kinase 22.7.11.220.465
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.464
2pvlP55Casein kinase II subunit alpha2.7.11.10.464
2w05FRTCyclin-dependent kinase 22.7.11.220.464
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.464
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.464
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.464
4i22IREEpidermal growth factor receptor2.7.10.10.464
4ix6ADPUncharacterized protein/0.464
5dosATPAurora kinase A2.7.11.10.464
1oiyN41Cyclin-dependent kinase 22.7.11.220.463
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2pvnP63Casein kinase II subunit alpha2.7.11.10.463
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.463
4bbfO19Tyrosine-protein kinase JAK2/0.463
4riyADPEpidermal growth factor receptor2.7.10.10.463
1h1s4SPCyclin-dependent kinase 22.7.11.220.462
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.462
3a62STURibosomal protein S6 kinase beta-12.7.11.10.462
4bbe3O4Tyrosine-protein kinase JAK2/0.462
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.461
2fvdLIACyclin-dependent kinase 22.7.11.220.461
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.461
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.461
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.461
2i40BLZCyclin-dependent kinase 22.7.11.220.460
3dfcANPDeath-associated protein kinase 12.7.11.10.460
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.460
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.460
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2hog710Serine/threonine-protein kinase Chk12.7.11.10.459
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.459
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.459
4ii5ADPCyclin-dependent kinase 22.7.11.220.459
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.459
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
1eh4IC1Casein kinase I homolog 12.7.11.10.458
1yvj4STTyrosine-protein kinase JAK32.7.10.20.458
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.458
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.458
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.458
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.457
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.457
3gu7ADPDeath-associated protein kinase 12.7.11.10.457
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.457
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.457
4jia1K3Tyrosine-protein kinase JAK2/0.457
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
4q5hANPProtein kinase OspG2.70.457
3at4CCKCasein kinase II subunit alpha2.7.11.10.456
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.456
4ysjADPCalmodulin-like domain protein kinase/0.456
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.456
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.455
2ijmATPFocal adhesion kinase 12.7.10.20.455
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
4bcmT7ZCyclin-dependent kinase 22.7.11.220.455
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.455
4fx360KCyclin-dependent kinase 22.7.11.220.455
5auxKMPDeath-associated protein kinase 12.7.11.10.455
2izuP01Casein kinase I isoform gamma-32.7.11.10.454
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.454
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.454
4fv9E71Mitogen-activated protein kinase 12.7.11.240.454
2etm7PYFocal adhesion kinase 12.7.10.20.453
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.453
2zjwREFCasein kinase II subunit alpha2.7.11.10.453
3ormAGSSerine/threonine protein kinase/0.453
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4fob0USALK tyrosine kinase receptor2.7.10.10.453
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.453
1ig1ANPDeath-associated protein kinase 12.7.11.10.452
2j0j4STFocal adhesion kinase 12.7.10.20.452
3igoANPCalmodulin-domain protein kinase 1, putative/0.452
1pjkANPCasein kinase II subunit alpha2.7.11.10.451
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1u54ACPActivated CDC42 kinase 1/0.451
2cchATPCyclin-dependent kinase 22.7.11.220.451
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.451
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.451
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.451
3bu5ATPInsulin receptor2.7.10.10.451
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.451
4ix5ANPUncharacterized protein/0.451
4kbk1QGCasein kinase I isoform delta2.7.11.10.451
2wihP48Cyclin-dependent kinase 22.7.11.220.450
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.450
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.450
4eooATPCyclin-dependent kinase 22.7.11.220.450
1finATPCyclin-dependent kinase 22.7.11.220.449
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.449
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.449
4anmWULCasein kinase II subunit alpha2.7.11.10.449
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
4hgt15GCasein kinase I isoform delta2.7.11.10.449
4iarERM5-hydroxytryptamine receptor 1B/0.449
2bujSTUSerine/threonine-protein kinase 16/0.448
2izt23DCasein kinase I isoform gamma-32.7.11.10.448
2j0lANPFocal adhesion kinase 12.7.10.20.448
2w4jADPDeath-associated protein kinase 12.7.11.10.448
3c50ADPRhodopsin kinase/0.448
3sheI85MAP kinase-activated protein kinase 32.7.11.10.448
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.448
4b99R4LMitogen-activated protein kinase 72.7.11.240.448
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.448
4fv6E57Mitogen-activated protein kinase 12.7.11.240.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
2x1nX1NCyclin-dependent kinase 22.7.11.220.447
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.447
4fkv61KCyclin-dependent kinase 22.7.11.220.447
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.447
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.446
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3s1h56ZCyclin-dependent kinase 22.7.11.220.446
4axdANPInositol-pentakisphosphate 2-kinase2.7.1.1580.446
4cd0AWJALK tyrosine kinase receptor2.7.10.10.446
4fod0UVALK tyrosine kinase receptor2.7.10.10.446
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.445
3uzp0CKCasein kinase I isoform delta2.7.11.10.445
3zxtACPDeath-associated protein kinase 12.7.11.10.445
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.445
5cvhADPCasein kinase II subunit alpha2.7.11.10.445
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.444
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.444
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.444
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
2etrY27Rho-associated protein kinase 12.7.11.10.444
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.444
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.444
3kf7L9GMitogen-activated protein kinase 14/0.444
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.444
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.444
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.444
1pmn984Mitogen-activated protein kinase 102.7.11.240.443
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.443
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.443
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2iw84SPCyclin-dependent kinase 22.7.11.220.443
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.443
2vv9IM9Cyclin-dependent kinase 22.7.11.220.443
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.443
1e9hINRCyclin-dependent kinase 22.7.11.220.442
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.442
2ojj82AMitogen-activated protein kinase 12.7.11.240.442
2oxtSAMGenome polyprotein/0.442
3gu83GUDeath-associated protein kinase 12.7.11.10.442
5av4GENDeath-associated protein kinase 12.7.11.10.442
1k6cMK1Gag-Pol polyprotein3.4.23.160.441
1tvoFRZMitogen-activated protein kinase 12.7.11.240.441
1zys199Serine/threonine-protein kinase Chk12.7.11.10.441
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.441
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3q9wEMOCasein kinase II subunit alpha2.7.11.10.441
3s2pPMUCyclin-dependent kinase 22.7.11.220.441
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.441
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.441
2c6hPXICytochrome P450 monooxygenase PikC/0.440
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.440
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.440
4hni16WCasein kinase I isoform epsilon2.7.11.10.440
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.440