sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2o2r | NDP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2o2r | NDP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 1.000 | |
| 4go2 | TAP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 0.659 | |
| 2ehq | NAP | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.636 | |
| 2o2q | NAP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 0.617 | |
| 4nmj | NAP | Aldehyde dehydrogenase | / | 0.588 | |
| 2esd | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.576 | |
| 2j40 | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.568 | |
| 4h73 | NDP | Aldehyde dehydrogenase | / | 0.567 | |
| 3n83 | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.560 | |
| 4zuk | NAD | Alpha-aminoadipic semialdehyde dehydrogenase | 1.2.1.31 | 0.560 | |
| 2eii | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.557 | |
| 4oe2 | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.556 | |
| 2j5n | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.555 | |
| 1qi1 | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.553 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.550 | |
| 2j6l | NAI | Alpha-aminoadipic semialdehyde dehydrogenase | 1.2.1.31 | 0.548 | |
| 2jg7 | NAD | Antiquitin | / | 0.547 | |
| 2ilu | NDP | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.540 | |
| 4fr8 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.540 | |
| 1bxs | NAD | Retinal dehydrogenase 1 | 1.2.1.36 | 0.539 | |
| 4nmk | NAP | Aldehyde dehydrogenase | / | 0.538 | |
| 4itb | NDP | Succinate-semialdehyde dehydrogenase | / | 0.537 | |
| 2y5d | NAP | 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase | / | 0.535 | |
| 4pxl | NAD | Aldehyde dehydrogenase3 | / | 0.535 | |
| 2ehu | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.534 | |
| 2onm | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.531 | |
| 1uxn | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.530 | |
| 1bpw | NAD | Betaine aldehyde dehydrogenase | 1.2.1.8 | 0.529 | |
| 3rhd | NAP | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.528 | |
| 2bhp | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.525 | |
| 2wme | NAP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.524 | |
| 1nzz | NAI | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.521 | |
| 3v9l | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.520 | |
| 2eit | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.519 | |
| 4fr8 | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.519 | |
| 4pt3 | NDP | Aldehyde dehydrogenase | / | 0.519 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.518 | |
| 4wb9 | NAI | Retinal dehydrogenase 1 | 1.2.1.36 | 0.513 | |
| 2d4e | NAD | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] | / | 0.512 | |
| 3iwk | NAD | Aminoaldehyde dehydrogenase | / | 0.512 | |
| 3n82 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.512 | |
| 1nzx | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.509 | |
| 4fqf | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.509 | |
| 4x4l | NAI | Retinal dehydrogenase 1 | 1.2.1.36 | 0.506 | |
| 1o01 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.505 | |
| 1nzw | NAI | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.503 | |
| 4pz2 | NAD | Aldehyde dehydrogenase 2-6 | / | 0.503 | |
| 2bja | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.502 | |
| 4zz7 | NAD | Methylmalonate-semialdehyde dehydrogenase | / | 0.501 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.499 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.499 | |
| 1o02 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.498 | |
| 1t90 | NAD | Malonate-semialdehyde dehydrogenase | 1.2.1.27 | 0.498 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.497 | |
| 4pxn | NAD | Aldehyde dehydrogenase family 7 member B4 | / | 0.495 | |
| 2onp | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.494 | |
| 3ju8 | NAD | N-succinylglutamate 5-semialdehyde dehydrogenase | 1.2.1.71 | 0.493 | |
| 4ihi | NAD | Probable pyrroline-5-carboxylate dehydrogenase RocA | / | 0.492 | |
| 1o00 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.491 | |
| 4a0m | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.490 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.490 | |
| 1cw3 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.488 | |
| 3lv1 | NAP | NAD(P)-dependent benzaldehyde dehydrogenase | 1.2.1.28 | 0.488 | |
| 4v37 | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.488 | |
| 3rhh | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.487 | |
| 1ad3 | NAD | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.485 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.485 | |
| 5eyu | NAD | Betaine-aldehyde dehydrogenase | / | 0.485 | |
| 4pt0 | NAD | Aldehyde dehydrogenase | / | 0.484 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.481 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.480 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.480 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.480 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.479 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.479 | |
| 1o04 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.478 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.478 | |
| 3lns | NAP | NAD(P)-dependent benzaldehyde dehydrogenase | 1.2.1.28 | 0.478 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.478 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.477 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.477 | |
| 3u8k | 09P | Acetylcholine-binding protein | / | 0.476 | |
| 3zok | NAD | 3-dehydroquinate synthase, chloroplastic | 4.2.3.4 | 0.476 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.475 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.475 | |
| 2xb5 | I7T | Tetracycline repressor protein class D | / | 0.474 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.474 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.474 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.473 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.472 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.471 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.471 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.470 | |
| 1osv | CHC | Bile acid receptor | / | 0.470 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.470 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.470 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.469 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.469 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.469 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.469 | |
| 4l9q | 9TP | Serum albumin | / | 0.468 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.467 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.467 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.467 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.467 | |
| 1qax | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.466 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.466 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.466 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.466 | |
| 1uh5 | TCL | Enoyl-ACP reductase | / | 0.465 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.465 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
| 4i1w | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.465 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.464 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.464 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.464 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.463 | |
| 1e3v | DXC | Steroid Delta-isomerase | 5.3.3.1 | 0.463 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.462 | |
| 1yre | COA | Uncharacterized protein | / | 0.462 | |
| 2c3y | HTL | Pyruvate synthase | / | 0.462 | |
| 3fzw | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.462 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.462 | |
| 3qce | NXY | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.462 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.462 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.462 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.462 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.462 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 1wnb | NAI | Gamma-aminobutyraldehyde dehydrogenase | 1.2.1.19 | 0.461 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.461 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.461 | |
| 2qe0 | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.461 | |
| 2yat | EEU | Estrogen receptor | / | 0.461 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.461 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.461 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.461 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.461 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.460 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.460 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.460 | |
| 4d7m | TDC | Tetracycline repressor protein class D | / | 0.460 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.460 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.460 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.460 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.460 | |
| 2o2s | TCL | Enoyl-acyl carrier reductase | / | 0.459 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.459 | |
| 1zdw | FLV | Prenyltransferase | / | 0.458 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.458 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.458 | |
| 3jsk | AHZ | Thiamine thiazole synthase | / | 0.458 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.458 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.458 | |
| 1kk4 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.457 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.457 | |
| 3v49 | PK0 | Androgen receptor | / | 0.457 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.457 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.457 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.457 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.457 | |
| 4inb | 1F6 | Gag protein | / | 0.457 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.457 | |
| 5fko | TDC | Tetracycline repressor protein class D | / | 0.457 | |
| 1fnd | A2P | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.456 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.456 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.456 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.456 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1ikv | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 1l0l | FMX | Cytochrome b | / | 0.455 | |
| 1ork | ATC | Tetracycline repressor protein class D | / | 0.455 | |
| 1upa | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.455 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.455 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2o2y | TCL | Enoyl-ACP reductase | / | 0.455 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.455 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 3stx | BKA | Methylketone synthase I | / | 0.455 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.455 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.455 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.454 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 2p15 | EZT | Estrogen receptor | / | 0.454 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.454 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.454 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.454 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.454 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.453 | |
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 | 0.453 | |
| 2c3p | 1TP | Pyruvate synthase | / | 0.453 | |
| 2ynf | WHU | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.453 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.453 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.453 | |
| 2bgj | FAD | NADPH:ferredoxin reductase | / | 0.452 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.452 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.452 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.452 | |
| 3a7d | FBN | Catechol O-methyltransferase | 2.1.1.6 | 0.452 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 3lov | FAD | Protoporphyrinogen oxidase | / | 0.452 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.452 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.452 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.452 | |
| 4iwv | 1J9 | Glucokinase | 2.7.1.2 | 0.452 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.452 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.452 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.452 | |
| 2fav | APR | Nonstructural polyprotein pp1a | / | 0.451 | |
| 2jj2 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.451 | |
| 2jj2 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.451 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.451 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.451 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4iwy | ADP | Ribosomal protein S6--L-glutamate ligase | / | 0.451 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.451 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.450 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.450 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.450 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.450 | |
| 4b3a | TAC | Tetracycline repressor protein class D | / | 0.450 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.450 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.450 | |
| 4rv9 | SAH | D-mycarose 3-C-methyltransferase | / | 0.450 | |
| 5ej4 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.450 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.449 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.449 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.449 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.449 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.449 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.449 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.449 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.449 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.449 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.449 | |
| 4okx | 198 | Androgen receptor | / | 0.449 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.448 | |
| 1kvo | OAP | Phospholipase A2, membrane associated | / | 0.448 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.448 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.448 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.448 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.448 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.448 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.448 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4ku3 | MYA | 3-oxoacyl-[ACP] synthase III | / | 0.448 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.448 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 1e3r | AND | Steroid Delta-isomerase | 5.3.3.1 | 0.447 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 1upc | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.447 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.447 | |
| 2y3s | TIR | TamL | / | 0.447 | |
| 3am4 | FT1 | Enoyl-ACP reductase | / | 0.447 | |
| 3lt1 | FT2 | Enoyl-ACP reductase | / | 0.447 | |
| 3p2e | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.447 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.447 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.447 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.447 | |
| 4a4w | YFB | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.447 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.447 | |
| 4x2q | NAD | Retinal dehydrogenase 2 | 1.2.1.36 | 0.447 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.446 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.446 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.446 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.446 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2pz5 | ACP | Fibroblast growth factor receptor 2 | / | 0.446 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.446 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.446 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 3d5f | L41 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 3e01 | PZ2 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.446 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.446 | |
| 4ku2 | MYA | 3-oxoacyl-[ACP] synthase III | / | 0.446 | |
| 4lva | 20M | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.446 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.446 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.446 | |
| 1gx1 | CDP | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.445 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.445 | |
| 1tll | NAP | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.445 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.445 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.445 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 3gob | HXX | DdmC | / | 0.445 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3upt | TPP | Transketolase | / | 0.445 | |
| 3vgl | ANP | Glucokinase | / | 0.445 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.445 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 4e0i | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.445 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.445 | |
| 5c88 | COA | N-alpha-acetyltransferase | / | 0.445 | |
| 5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.445 | |
| 1adc | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2pr5 | FMN | Blue-light photoreceptor | / | 0.444 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.444 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 3am5 | TCL | Enoyl-ACP reductase | / | 0.444 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 3exn | ACO | Probable acetyltransferase | / | 0.444 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.444 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.444 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.444 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.444 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.443 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.443 | |
| 2ijm | ADP | Focal adhesion kinase 1 | 2.7.10.2 | 0.443 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.443 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.443 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.443 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.443 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3lt2 | FT3 | Enoyl-ACP reductase | / | 0.443 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.443 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.443 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.443 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.443 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1dxr | MST | Reaction center protein L chain | / | 0.442 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 2fdv | D2G | Cytochrome P450 2A6 | 1.14.13 | 0.442 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.442 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 2toh | HBI | Tyrosine 3-monooxygenase | 1.14.16.2 | 0.442 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.442 | |
| 3aox | EMH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.442 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.442 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.442 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.442 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.442 | |
| 5buk | FAD | FADH2-dependent halogenase | / | 0.442 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.441 | |
| 1iqr | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.441 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.441 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.441 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.441 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3am3 | TCL | Enoyl-ACP reductase | / | 0.441 | |
| 3c6u | M22 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.441 | |
| 3lsy | FT0 | Enoyl-ACP reductase | / | 0.441 | |
| 3o7l | ANP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.441 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.441 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 4ihl | 1F5 | 14-3-3 protein zeta/delta | / | 0.441 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.441 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.441 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.441 | |
| 1c2t | NHS | Phosphoribosylglycinamide formyltransferase | / | 0.440 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.440 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.440 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.440 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.440 | |
| 1ysx | 4EB | Serum albumin | / | 0.440 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.440 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.440 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.440 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.440 | |
| 4xvu | ATP | ATPase GET3 | / | 0.440 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 |