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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2o2143BApoptosis regulator Bcl-2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2o2143BApoptosis regulator Bcl-2/1.000
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.502
4lxd1XVApoptosis regulator Bcl-2/0.479
1dgbNDPCatalase1.11.1.60.477
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.475
1dggNDPCatalase1.11.1.60.473
4man1Y1Apoptosis regulator Bcl-2/0.468
4kfj1R0Dihydrofolate reductase1.5.1.30.466
7catNDPCatalase1.11.1.60.465
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.463
1rf9DBRCamphor 5-monooxygenase1.14.15.10.462
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4o761M3Bromodomain-containing protein 4/0.459
1zzqDP9Nitric oxide synthase, brain1.14.13.390.457
3dqrJI2Nitric oxide synthase, brain1.14.13.390.457
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.457
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.455
8catNDPCatalase1.11.1.60.455
3nwlNDPCatalase1.11.1.60.454
4a33PS8Glycylpeptide N-tetradecanoyltransferase/0.453
2r0cFADPutative FAD-monooxygenase/0.451
3oafOAGDihydrofolate reductase1.5.1.30.451
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.449
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3zsh469Mitogen-activated protein kinase 14/0.448
1kqnNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.446
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.446
2woeAR6ADP-ribosyl-[dinitrogen reductase] glycohydrolase3.2.2.240.446
3btjDEQHTH-type transcriptional regulator QacR/0.444
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.443
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
4nieDMXNuclear receptor ROR-gamma/0.443
2z3uCRRCytochrome P450/0.442
4euxHW1Nitric oxide synthase, brain1.14.13.390.442
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
1rdtL79Retinoic acid receptor RXR-alpha/0.441
4bz7B3NHistone deacetylase/0.441
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.441
4jvlESTEstrogen sulfotransferase2.8.2.40.441
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3jx4J11Nitric oxide synthase, brain1.14.13.390.440