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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2o1oRISPutative farnesyl pyrophosphate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2o1oRISPutative farnesyl pyrophosphate synthase/1.000
3dyh721Farnesyl pyrophosphate synthase/0.531
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.482
3rywK9HFarnesyl pyrophosphate synthase, putative/0.482
5ero210Fusicoccadiene synthase2.5.1.290.481
3egt722Farnesyl pyrophosphate synthase/0.480
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.480
1yq7RISFarnesyl pyrophosphate synthase2.5.1.100.477
1rqjRISFarnesyl diphosphate synthase2.5.1.100.474
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.474
2f94BFQFarnesyl pyrophosphate synthase2.5.1.100.470
2e8wIPEGeranylgeranyl pyrophosphate synthase/0.467
3rbmB73Farnesyl pyrophosphate synthase, putative/0.466
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.466
2oz57XYUncharacterized protein/0.460
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.455
2vjmCOAFormyl-CoA:oxalate CoA-transferase/0.455
4dwb0M7Farnesyl pyrophosphate synthase/0.455
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.454
1t3zCAOFormyl-CoA:oxalate CoA-transferase/0.453
1u28NAPNAD(P) transhydrogenase subunit beta1.6.1.20.453
4dxj0M9Farnesyl pyrophosphate synthase/0.453
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.452
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.452
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.447
4p5aFADFlavin-dependent thymidylate synthase/0.447
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.446
5ej5TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.446
2w2lNADD-mandelate dehydrogenase/0.445
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.444
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.444
1f0yNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.443
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.443
1wuuANPGalactokinase2.7.1.60.443
5kwvANPPantothenate synthetase/0.443
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.442
2e94364Geranylgeranyl pyrophosphate synthase/0.442
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.442
4y9lFADAcyl-CoA dehydrogenase family member 11/0.442
5idwNAPShort-chain dehydrogenase/reductase SDR/0.442
3fx4FX4Alcohol dehydrogenase [NADP(+)]1.1.1.20.441
3ndjJHZMethyltransferase/0.441
3tqcADPPantothenate kinase/0.440