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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.11.000
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.593
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.574
4qmpDKISerine/threonine-protein kinase 242.7.11.10.555
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.547
1di8DTQCyclin-dependent kinase 22.7.11.220.515
3uli1N3Cyclin-dependent kinase 22.7.11.220.514
2iw84SPCyclin-dependent kinase 22.7.11.220.512
1oiyN41Cyclin-dependent kinase 22.7.11.220.511
2b7aIZATyrosine-protein kinase JAK2/0.509
3rmf20ZCyclin-dependent kinase 22.7.11.220.509
4aqc88ATyrosine-protein kinase JAK2/0.509
2pvnP63Casein kinase II subunit alpha2.7.11.10.508
1oi9N20Cyclin-dependent kinase 22.7.11.220.505
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.504
2eufLQQCyclin-dependent kinase 62.7.11.220.499
3r9oZ71Cyclin-dependent kinase 22.7.11.220.499
3s1h56ZCyclin-dependent kinase 22.7.11.220.496
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.496
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.496
1aq1STUCyclin-dependent kinase 22.7.11.220.492
2pvhP19Casein kinase II subunit alpha2.7.11.10.491
5e8wSTUTGF-beta receptor type-12.7.11.300.491
4jia1K3Tyrosine-protein kinase JAK2/0.490
3zep1NXTyrosine-protein kinase JAK32.7.10.20.488
3be9P04Casein kinase II subunit alpha2.7.11.10.485
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.484
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.484
2uzlC94Cyclin-dependent kinase 22.7.11.220.481
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.479
4erwSTUCyclin-dependent kinase 22.7.11.220.479
1gih1PUCyclin-dependent kinase 22.7.11.220.477
2xikJ60Serine/threonine-protein kinase 252.7.11.10.477
4jr7GNPCasein kinase II subunit alpha2.7.11.10.477
1h1s4SPCyclin-dependent kinase 22.7.11.220.476
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.476
1g5sI17Cyclin-dependent kinase 22.7.11.220.475
3rk708ZCyclin-dependent kinase 22.7.11.220.475
2c6tDT5Cyclin-dependent kinase 22.7.11.220.474
3r9dX6BCyclin-dependent kinase 22.7.11.220.474
2xmyCDKCyclin-dependent kinase 22.7.11.220.473
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.473
1urwI1PCyclin-dependent kinase 22.7.11.220.472
4dgnLU2Casein kinase II subunit alpha2.7.11.10.472
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.471
3qu0X40Cyclin-dependent kinase 22.7.11.220.471
2cchATPCyclin-dependent kinase 22.7.11.220.470
3rak03ZCyclin-dependent kinase 22.7.11.220.470
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.470
2iw94SPCyclin-dependent kinase 22.7.11.220.469
2wihP48Cyclin-dependent kinase 22.7.11.220.469
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.469
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.469
2x1nX1NCyclin-dependent kinase 22.7.11.220.468
3ezvEZVCyclin-dependent kinase 22.7.11.220.468
3qtzX42Cyclin-dependent kinase 22.7.11.220.468
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.468
4jqeANPCasein kinase II subunit alpha2.7.11.10.468
1h1r6CPCyclin-dependent kinase 22.7.11.220.467
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.467
3r9hZ67Cyclin-dependent kinase 22.7.11.220.467
3rk507ZCyclin-dependent kinase 22.7.11.220.467
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.466
3ral04ZCyclin-dependent kinase 22.7.11.220.466
3zmmF9JTyrosine-protein kinase JAK2/0.466
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.466
1ke6LS2Cyclin-dependent kinase 22.7.11.220.465
3ggfGVDSerine/threonine-protein kinase 26/0.465
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.465
3l8p0CEAngiopoietin-1 receptor2.7.10.10.464
4fko20KCyclin-dependent kinase 22.7.11.220.464
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.464
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.464
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.463
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.463
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.463
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.463
2j0m4STFocal adhesion kinase 12.7.10.20.462
4e4m0NHTyrosine-protein kinase JAK2/0.462
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.462
5cvhADPCasein kinase II subunit alpha2.7.11.10.462
1e9hINRCyclin-dependent kinase 22.7.11.220.461
1gij2PUCyclin-dependent kinase 22.7.11.220.461
1oiuN76Cyclin-dependent kinase 22.7.11.220.461
1pkdUCNCyclin-dependent kinase 22.7.11.220.461
2vu3LZECyclin-dependent kinase 22.7.11.220.461
3le62BZCyclin-dependent kinase 22.7.11.220.461
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.461
4bcoT6QCyclin-dependent kinase 22.7.11.220.461
4ji91M3Tyrosine-protein kinase JAK2/0.461
2w05FRTCyclin-dependent kinase 22.7.11.220.460
3bi6396Wee1-like protein kinase2.7.10.20.460
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.460
4bgg844Activin receptor type-12.7.11.300.460
1oguST8Cyclin-dependent kinase 22.7.11.220.459
2xnbY8LCyclin-dependent kinase 22.7.11.220.459
4bbfO19Tyrosine-protein kinase JAK2/0.459
4bcpT3CCyclin-dependent kinase 22.7.11.220.459
4hge15VTyrosine-protein kinase JAK2/0.459
1bygSTUTyrosine-protein kinase CSK/0.458
2i40BLZCyclin-dependent kinase 22.7.11.220.458
4eok4SPCyclin-dependent kinase 22.7.11.220.458
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.458
1fvv107Cyclin-dependent kinase 22.7.11.220.457
2bhhRYUCyclin-dependent kinase 22.7.11.220.457
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.457
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.457
3qxpX64Cyclin-dependent kinase 22.7.11.220.457
4fkv61KCyclin-dependent kinase 22.7.11.220.457
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.457
4qmySTUSerine/threonine-protein kinase 242.7.11.10.457
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.456
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.456
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.456
2vttLZDCyclin-dependent kinase 22.7.11.220.456
2xa4AZ5Tyrosine-protein kinase JAK2/0.456
3gxlQIGTGF-beta receptor type-12.7.11.300.456
3lfnA27Cyclin-dependent kinase 22.7.11.220.456
3rpv26ZCyclin-dependent kinase 22.7.11.220.456
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.456
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.456
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.456
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.456
1vjy460TGF-beta receptor type-12.7.11.300.455
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.455
3roy22ZCyclin-dependent kinase 22.7.11.220.455
4grb0XGCasein kinase II subunit alpha2.7.11.10.455
4gub0Y4Casein kinase II subunit alpha2.7.11.10.455
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.454
4anmWULCasein kinase II subunit alpha2.7.11.10.454
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.454
4iva1J5Tyrosine-protein kinase JAK2/0.454
1om1IQACasein kinase II subunit alpha2.7.11.10.453
3lpbNVBTyrosine-protein kinase JAK2/0.453
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.452
2wxvWXVCyclin-dependent kinase 22.7.11.220.452
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.452
3qtxX43Cyclin-dependent kinase 22.7.11.220.452
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.452
4fkw62KCyclin-dependent kinase 22.7.11.220.452
2hog710Serine/threonine-protein kinase Chk12.7.11.10.451
3sw418KCyclin-dependent kinase 22.7.11.220.451
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4fkr45KCyclin-dependent kinase 22.7.11.220.451
4gmy0X5Tyrosine-protein kinase JAK2/0.451
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.450
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.450
3rni21ZCyclin-dependent kinase 22.7.11.220.450
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.450
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.449
2igoFADPyranose 2-oxidase/0.449
2j9mPY8Cyclin-dependent kinase 22.7.11.220.449
3zh8C58Protein kinase C iota type2.7.11.130.449
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.449
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.448
1xddAAYIntegrin alpha-L/0.447
2vv9IM9Cyclin-dependent kinase 22.7.11.220.447
3iok1P6Tyrosine-protein kinase JAK2/0.447
3lqfNADGalactitol dehydrogenase/0.447
4dgmAGICasein kinase II subunit alpha2.7.11.10.447
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.447
1dawANPCasein kinase II subunit alpha2.7.11.10.446
1m2rMNYCasein kinase II subunit alpha2.7.11.10.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
3dogNNNCyclin-dependent kinase 22.7.11.220.446
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.446
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.445
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.445
3py0SU9Cyclin-dependent kinase 22.7.11.220.445
4dgo0JWCasein kinase II subunit alpha2.7.11.10.445
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
5jscFADPutative acyl-CoA dehydrogenase/0.445
2c5nCK8Cyclin-dependent kinase 22.7.11.220.444
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.444
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.444
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.444
4dymIYZActivin receptor type-12.7.11.300.444
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.444
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.443
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.443
3zewSTUEphrin type-B receptor 42.7.10.10.443
4bcnT9NCyclin-dependent kinase 22.7.11.220.443
4wsqKSAAP2-associated protein kinase 12.7.11.10.443
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.442
4c61LMMTyrosine-protein kinase JAK2/0.442
4fx360KCyclin-dependent kinase 22.7.11.220.442
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.442
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1xjdSTUProtein kinase C theta type2.7.11.130.441
2w06FRVCyclin-dependent kinase 22.7.11.220.441
2w17I19Cyclin-dependent kinase 22.7.11.220.441
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.441
3begANPSRSF protein kinase 12.7.11.10.441
3ddpRC8Cyclin-dependent kinase 22.7.11.220.441
3own3OWRenin3.4.23.150.441
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.441
4hvh19RTyrosine-protein kinase JAK32.7.10.20.441
2uzdC85Cyclin-dependent kinase 22.7.11.220.440
3at3ATKCasein kinase II subunit alpha2.7.11.10.440
3unj0BXCyclin-dependent kinase 22.7.11.220.440
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.440