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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2nliFMNLactate oxidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2nliFMNLactate oxidase/1.000
2zfaFMNLactate oxidase/0.546
1kbiFMNCytochrome b2, mitochondrial1.1.2.30.537
2e77FMNLactate oxidase/0.526
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.523
2j6xFMNLactate oxidase/0.521
1goxFMNPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.520
1kbjFMNCytochrome b2, mitochondrial1.1.2.30.519
5ebuFMNLactate oxidase/0.519
1szgFNSCytochrome b2, mitochondrial1.1.2.30.515
3giyFMN(S)-mandelate dehydrogenase1.1.99.310.512
4yl2FMNLactate oxidase/0.504
4rjeFNRLactate oxidase/0.501
1szfFMNCytochrome b2, mitochondrial1.1.2.30.491
4h6kFMNNADPH dehydrogenase 11.6.99.10.483
2oz0FMNCytochrome b2, mitochondrial1.1.2.30.482
3p62FMNPentaerythritol tetranitrate reductase/0.475
1h63FMNPentaerythritol tetranitrate reductase/0.474
3f03FMNPentaerythritol tetranitrate reductase/0.474
3hf3FMNChromate reductase/0.473
1z44FMNNADPH dehydrogenase/0.468
2oapANPType II secretion system protein (GspE-2)/0.467
3p74FMNPentaerythritol tetranitrate reductase/0.465
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.463
2du2FMNLactate oxidase/0.461
4qaiFMNNADPH dehydrogenase/0.459
1qcwFNSCytochrome b2, mitochondrial1.1.2.30.458
3p84FMNPentaerythritol tetranitrate reductase/0.457
1bwsNDPGDP-L-fucose synthase/0.456
1vyrFMNPentaerythritol tetranitrate reductase/0.456
1bwlFMNNADPH dehydrogenase 11.6.99.10.455
1h51FMNPentaerythritol tetranitrate reductase/0.454
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1icqFMN12-oxophytodienoate reductase 11.3.1.420.453
3p67FMNPentaerythritol tetranitrate reductase/0.453
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.452
4gtlFADFlavin-dependent thymidylate synthase2.1.1.1480.452
2x7hPFNProstaglandin reductase 310.451
5ckuNAPL-ornithine N(5)-monooxygenase/0.451
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2gjlFMNNitronate monooxygenase1.13.12.160.450
2abbFMNPentaerythritol tetranitrate reductase/0.449
2eixFADNADH-cytochrome b5 reductase/0.449
3p8jFMNPentaerythritol tetranitrate reductase/0.449
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.448
4rnuFMNNADPH dehydrogenase 11.6.99.10.448
5idwNAPShort-chain dehydrogenase/reductase SDR/0.448
3b70NAPEnoyl reductase LovC10.447
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.446
4jicFMNGTN Reductase/0.446
1kq4FADFlavin-dependent thymidylate synthase2.1.1.1480.444
3l5lFMNXenobiotic reductase/0.444
4n9wGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.444
4uthFMNXenobiotic reductase/0.444
1ipeNDPTropinone reductase 21.1.1.2360.443
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.443
3p82FMNPentaerythritol tetranitrate reductase/0.443
4d03FADPhenylacetone monooxygenase1.14.13.920.443
1nzdUPGDNA beta-glucosyltransferase/0.442
1oycFMNNADPH dehydrogenase 11.6.99.10.442
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.442
4y7cNAPNADPH--cytochrome P450 reductase/0.442
1h50FMNPentaerythritol tetranitrate reductase/0.441
2cmkCDPCytidylate kinase2.7.4.250.441
3af1GDPPantothenate kinase2.7.1.330.441
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.440
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.440
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
5cwa0GAAnthranilate synthase component 14.1.3.270.440