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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2jg7NADAntiquitin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2jg7NADAntiquitin/1.000
2j6lNAIAlpha-aminoadipic semialdehyde dehydrogenase1.2.1.310.583
4pxnNADAldehyde dehydrogenase family 7 member B4/0.543
3hazNADBifunctional protein PutA/0.506
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.490
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.483
4zz7NADMethylmalonate-semialdehyde dehydrogenase/0.483
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.480
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.480
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.476
4pz2NADAldehyde dehydrogenase 2-6/0.476
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.464
3lv1NAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.461
4i3vNADAldehyde dehydrogenase (NAD+)/0.461
3v9lNADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.456
1bxsNADRetinal dehydrogenase 11.2.1.360.450
2esdNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase1.2.1.90.448
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.447
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.446
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.444
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.443