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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2jd1NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2jd1NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/1.000
2jd0NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.708
1q0qNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.573
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.497
3ggoNAIPrephenate dehydrogenase/0.495
4dpmCOAMalonyl-CoA reductase1.2.1.750.490
1nvmNADAcetaldehyde dehydrogenase1.2.1.100.484
1c1dNAIPhenylalanine dehydrogenase/0.465
3ceaNADMyo-inositol 2-dehydrogenase-like (Promiscuous)/0.464
2dbrNAPGlyoxylate reductase1.1.1.260.462
2g5cNADPrephenate dehydrogenase/0.462
4jbiNDPAlcohol dehydrogenase (Zinc)/0.462
2c0cNAPProstaglandin reductase 310.460
1nvtNAPShikimate dehydrogenase (NADP(+))/0.459
2f1kNAPPrephenate dehydrogenase/0.458
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.458
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.458
3abiNADUncharacterized protein/0.456
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.455
2p9eNAID-3-phosphoglycerate dehydrogenase1.1.1.950.452
4dplNAPMalonyl-CoA reductase1.2.1.750.450
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.449
4e5yNDPGDP-L-fucose synthase1.1.1.2710.449
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.449
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.448
1nytNAPShikimate dehydrogenase (NADP(+))/0.447
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.447
1gypNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.446
2ahrNAPPyrroline-5-carboxylate reductase/0.446
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.445
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.444
1zemNADXylitol dehydrogenase/0.444
3toxNAPPutative oxidoreductase/0.444
3gggNADPrephenate dehydrogenase/0.443
3gw9VNILanosterol 14-alpha-demethylase/0.443
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.443
2vyvNADGlyceraldehyde-3-phosphate dehydrogenase A/0.442
3b70NAPEnoyl reductase LovC10.442
3iupNDPPossible NADH oxidoreductase/0.442
3wmxNADNAD dependent epimerase/dehydratase/0.442
2rcyNAPPyrroline-5-carboxylate reductase/0.441
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4plpNADHomospermidine synthase2.5.1.440.441
4xyeNADFormate dehydrogenase/0.440