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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.17

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.171.000
4r20AERCytochrome P450 family 17 polypeptide 2/0.483
1q5dEPBEpothilone C/D epoxidase1.140.478
1pkfEPDEpothilone C/D epoxidase1.140.477
3abaFLICytochrome P450/0.470
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.463
3tubFPUTyrosine-protein kinase SYK2.7.10.20.459
2owb626Serine/threonine-protein kinase PLK12.7.11.210.458
3rfmCFFAdenosine receptor A2a/0.458
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.457
4jbtASDCytochrome P450 monooxygenase/0.455
3tdaPN0Cytochrome P450 2D6/0.453
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
4equG6ISerine/threonine-protein kinase 102.7.11.10.451
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.450
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.450
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.449
3uzcT4EAdenosine receptor A2a/0.449
3t8xT8XT-cell surface glycoprotein CD1b/0.448
3uzaT4GAdenosine receptor A2a/0.448
4j6dTESCytochrome P450 monooxygenase/0.447
1g63FMNEpidermin decarboxylase4.1.10.446
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3g6zA7TRenin3.4.23.150.446
5iua6DXAdenosine receptor A2a/0.446
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.445
3pe2E1BCasein kinase II subunit alpha2.7.11.10.444
4j6bPLOCytochrome P450 monooxygenase/0.443
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.442
3gcq1BUMitogen-activated protein kinase 14/0.442
3p3zP3ZPutative cytochrome P450/0.442
2yac937Serine/threonine-protein kinase PLK12.7.11.210.441
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.441
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.440