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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2jav5Z5Serine/threonine-protein kinase Nek22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2jav5Z5Serine/threonine-protein kinase Nek22.7.11.11.000
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.574
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.538
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.516
2xnoED8Serine/threonine-protein kinase Nek22.7.11.10.504
2zs9ADPPantothenate kinase2.7.1.330.489
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.478
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.471
3af1GDPPantothenate kinase2.7.1.330.469
2owb626Serine/threonine-protein kinase PLK12.7.11.210.466
3af0GDPPantothenate kinase2.7.1.330.465
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.464
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.463
1pkfEPDEpothilone C/D epoxidase1.140.462
2yac937Serine/threonine-protein kinase PLK12.7.11.210.460
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.460
2zs8ADPPantothenate kinase2.7.1.330.458
3gcq1BUMitogen-activated protein kinase 14/0.456
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.455
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.454
2x9vTMQPteridine reductase/0.454
4g1nNZTPyruvate kinase PKM2.7.1.400.454
2zsdCOAPantothenate kinase2.7.1.330.453
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.452
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.451
1q5dEPBEpothilone C/D epoxidase1.140.450
2getCOKPantothenate kinase2.7.1.330.450
1u1gBBBUridine phosphorylase2.4.2.30.448
2ejzSAHDiphthine synthase/0.448
2gesCOKPantothenate kinase2.7.1.330.448
2zsbADPPantothenate kinase2.7.1.330.448
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.447
2ydoADNAdenosine receptor A2a/0.447
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.447
3aezGDPPantothenate kinase2.7.1.330.446
3e6tH4BNitric oxide synthase, inducible1.14.13.390.446
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.445
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.444
2j4lUTPUridylate kinase2.7.4.220.444
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.444
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.444
4kfj1R0Dihydrofolate reductase1.5.1.30.444
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.443
2z2w770Wee1-like protein kinase2.7.10.20.443
5bn4ANPV-type ATP synthase alpha chain/0.443
2gevCOKPantothenate kinase2.7.1.330.442
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.442
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.441
4l0oPLPCystathionine gamma-synthase2.5.1.480.441
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.440