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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2j7t274Serine/threonine-protein kinase 102.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2j7t274Serine/threonine-protein kinase 102.7.11.11.000
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.467
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.463
4nka2K7Fibroblast growth factor receptor 1/0.450
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.447
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.447
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
3w2sW2REpidermal growth factor receptor2.7.10.10.444
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.443
4wkqIREEpidermal growth factor receptor2.7.10.10.442
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.440
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440