sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 1.000 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.632 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.485 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.465 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.464 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.463 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.461 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.461 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.460 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.458 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.457 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.457 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.457 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.457 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.453 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.453 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.453 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.451 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.450 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.449 | |
| 4yvz | 3AT | DNA integrity scanning protein DisA | / | 0.449 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.448 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.447 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.447 | |
| 5cfp | C2E | Stimulator of interferon genes protein | / | 0.447 | |
| 1vjt | NAD | Alpha-glucosidase, putative | / | 0.446 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.446 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.446 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.446 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.446 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.445 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.444 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.444 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.442 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.442 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.442 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.441 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4dja | FAD | (6-4) photolyase | / | 0.441 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.441 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.440 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.440 |