sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 1.000 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.735 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.699 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.699 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.692 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.651 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.637 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.636 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.635 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.633 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.626 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.616 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.615 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.613 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.610 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.606 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.606 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.605 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.604 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.602 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.598 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.597 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.592 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.590 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.590 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.590 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.578 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.572 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.567 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.557 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.554 | |
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.543 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.543 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.539 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.538 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.536 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.535 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.534 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.528 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.524 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.523 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.521 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.521 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.520 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.520 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.519 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.517 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.515 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.514 | |
| 3h4g | FID | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.512 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.511 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.511 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.510 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.509 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.509 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.509 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.508 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.508 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.507 | |
| 1rxj | BNI | Streptavidin | / | 0.505 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.504 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.503 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.503 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.503 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.503 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.502 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.501 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.500 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.498 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.498 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.497 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.497 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.497 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.497 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.497 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.496 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.496 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.495 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.495 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.495 | |
| 2hzq | STR | Apolipoprotein D | / | 0.495 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.495 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.495 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.495 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.494 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.493 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.492 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.492 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.492 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.491 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.491 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.491 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.491 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.491 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.490 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.489 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.489 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.489 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.489 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.489 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.488 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.488 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.487 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.487 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.487 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.487 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.485 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.484 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.484 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.483 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.482 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.482 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.481 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.481 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.481 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.481 | |
| 2po3 | T4K | 4-dehydrase | / | 0.481 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.481 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.480 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.480 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.480 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.480 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.479 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 3c1o | NAP | Eugenol synthase | / | 0.479 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.479 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.479 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.478 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.478 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.478 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.478 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.478 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.477 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.477 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.477 | |
| 3zo7 | K6H | Muconolactone Delta-isomerase | / | 0.477 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.477 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4mrx | CZH | Obelin | / | 0.477 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.476 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.476 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.476 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.476 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.476 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.476 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.475 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.475 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.475 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.475 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.475 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.474 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.474 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.474 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.474 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.473 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.473 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.472 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.472 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.472 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.472 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.472 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.472 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.472 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.471 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.471 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 3f6s | FMN | Flavodoxin | / | 0.471 | |
| 4j7h | TRH | PCZA361.3 | / | 0.471 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.471 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.471 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.470 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.469 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.469 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.469 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.468 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.468 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.468 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.468 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.468 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.468 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.468 | |
| 4yfy | 0FX | VioF | / | 0.468 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 1qvt | PRL | HTH-type transcriptional regulator QacR | / | 0.467 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.467 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 3w2e | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.467 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.467 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.467 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.466 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 2vq3 | NAP | Metalloreductase STEAP3 | / | 0.466 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.466 | |
| 3jqg | AX6 | Pteridine reductase, putative | / | 0.466 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.466 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 1lke | DOG | Bilin-binding protein | / | 0.465 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.465 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.465 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.465 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.465 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1uk1 | FRQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.464 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.464 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.464 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.464 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.464 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.464 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.464 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.463 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.463 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.463 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.463 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.463 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.463 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.463 | |
| 1az1 | ALR | Aldose reductase | 1.1.1.21 | 0.462 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.462 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.462 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.462 | |
| 2iuz | D1H | Endochitinase B1 | 3.2.1.14 | 0.462 | |
| 2zoz | ET | Transcriptional regulator | / | 0.462 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.462 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.462 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.462 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.462 | |
| 5agk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.462 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.461 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.461 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.461 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 3cui | X4S | Exoglucanase/xylanase | 3.2.1.91 | 0.461 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3ocx | 2AM | Lipoprotein E | / | 0.461 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.461 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.461 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.461 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.460 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.460 | |
| 1s36 | CEI | Obelin | / | 0.460 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.460 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.460 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.460 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.460 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.460 | |
| 4j7g | TRH | PCZA361.3 | / | 0.460 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.459 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.459 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.459 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.459 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.459 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 4a7z | AY9 | Aldos-2-ulose dehydratase | / | 0.459 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.459 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.459 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.459 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.459 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.459 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.459 | |
| 5d0r | B1T | Adenylate cyclase type 10 | / | 0.459 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.459 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.458 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.458 | |
| 2xej | OKD | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.458 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.458 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.458 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 4bvh | OCZ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.458 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.458 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.458 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.458 | |
| 5jr3 | 4MU | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.458 | |
| 2ycz | I32 | Beta-1 adrenergic receptor | / | 0.458 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.457 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.457 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.457 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.457 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.456 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.456 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.456 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.456 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.455 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.455 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.455 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.455 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.455 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.455 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.455 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.454 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.454 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.454 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.454 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.454 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.454 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.454 | |
| 2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.454 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.454 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.454 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.454 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.454 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.454 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.454 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.454 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.454 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.454 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.453 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.453 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.453 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.453 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.453 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.453 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.453 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.453 | |
| 4l1x | STR | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4x3u | SVR | Chromobox protein homolog 7 | / | 0.453 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.452 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.452 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.452 | |
| 3gsi | THG | Dimethylglycine oxidase | 1.5.3.10 | 0.452 | |
| 3hth | PRL | EbrA repressor | / | 0.452 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 4azw | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.452 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.452 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.451 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.451 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.451 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.451 | |
| 3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3b9g | IMH | IAG-nucleoside hydrolase | / | 0.451 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.451 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.451 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 4qtn | NNR | Nicotinamide riboside transporter PnuC | / | 0.451 | |
| 4to6 | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.450 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.450 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.450 | |
| 2y03 | 5FW | Beta-1 adrenergic receptor | / | 0.450 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.450 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.450 | |
| 3vhh | VHH | Avidin | / | 0.450 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 4khn | XG4 | DNA-directed DNA polymerase | / | 0.450 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.450 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.449 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.449 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.449 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.449 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.449 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.449 | |
| 2cje | DUN | DUTPase | / | 0.449 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.449 | |
| 2j7d | GI1 | Beta-glucosidase A | 3.2.1.21 | 0.449 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.449 | |
| 3r94 | FLR | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.449 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.449 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 4kmz | FOL | Folate receptor beta | / | 0.449 | |
| 4gbr | CAU | Beta-2 adrenergic receptor | / | 0.449 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.448 | |
| 2jgs | BTN | Avidin | / | 0.448 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.448 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.448 | |
| 3hyw | DCQ | Sulfide-quinone reductase | / | 0.448 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3of3 | DIH | Purine nucleoside phosphorylase DeoD-type 1 | / | 0.448 | |
| 3zpq | XF5 | Beta-1 adrenergic receptor | / | 0.448 | |
| 4dlc | UMP | Deoxyuridine triphosphatase, putative | / | 0.448 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.448 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.447 | |
| 1m9m | 6NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.447 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.447 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.447 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.447 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.447 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 3o76 | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.447 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.447 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.447 | |
| 3rme | RME | Acidic mammalian chitinase | 3.2.1.14 | 0.447 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.447 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 4jtp | ASC | Ribosome inactivating protein | / | 0.447 | |
| 1eir | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.446 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1n0s | FLU | Bilin-binding protein | / | 0.446 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.446 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2gmv | UN8 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.446 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.446 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.446 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.446 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.446 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4cb4 | MGT | Polymerase basic protein 2 | / | 0.446 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4n1f | CZH | Obelin | / | 0.446 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.446 | |
| 1ddt | APU | Diphtheria toxin | / | 0.445 | |
| 1jf2 | CZH | Obelin | / | 0.445 | |
| 1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2gh6 | CF3 | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.445 | |
| 2gl0 | ADN | Uncharacterized protein | / | 0.445 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3br2 | DEQ | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 3gwn | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.445 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4cb7 | 41G | Polymerase basic protein 2 | / | 0.445 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.445 | |
| 4nv7 | COA | Arylamine N-acetyltransferase | / | 0.445 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.445 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.445 | |
| 1c7o | PPG | Hemolysin | / | 0.444 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.444 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.444 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1vft | DCS | Alanine racemase | / | 0.444 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.444 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.444 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.444 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 3jt6 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 3n61 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4dya | 0MF | Nucleoprotein | / | 0.444 | |
| 4uqs | INE | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.444 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1e2l | TMC | Thymidine kinase | / | 0.443 | |
| 1fwy | UD1 | Bifunctional protein GlmU | / | 0.443 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.443 | |
| 1isj | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.443 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1uhj | CZB | Aequorin-2 | / | 0.443 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.443 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.443 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.443 | |
| 3nhl | YTR | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.443 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 3up3 | XCA | aceDAF-12 | / | 0.443 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.443 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4dyb | 0MH | Nucleoprotein | / | 0.443 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.443 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4phl | PIL | Phosphodiesterase | / | 0.443 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 1swn | BTN | Streptavidin | / | 0.442 | |
| 2fje | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.442 | |
| 2oac | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.442 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.442 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.442 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.442 | |
| 3jt3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.442 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.442 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.442 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 5agp | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1el4 | CTZ | Obelin | / | 0.441 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.441 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
| 1swg | BTN | Streptavidin | / | 0.441 | |
| 1w29 | TS1 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.441 | |
| 2zi6 | 3D1 | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.441 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.441 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.441 | |
| 3voi | RCB | Glucanase | / | 0.441 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4xcz | T3Q | Qdtf | / | 0.441 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 2y04 | 68H | Beta-1 adrenergic receptor | / | 0.441 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.440 | |
| 1ogx | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 1xid | ASC | Xylose isomerase | 5.3.1.5 | 0.440 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.440 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.440 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3irh | DTP | HD domain protein | / | 0.440 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.440 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
| 3upr | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.440 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.440 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4cb6 | 29R | Polymerase basic protein 2 | / | 0.440 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.440 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 4iae | 1DX | Alr2278 protein | / | 0.440 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4xwt | U5P | Ribonuclease J | / | 0.440 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.440 | |
| 5epv | ACP | Blue-light-activated histidine kinase | 2.7.13.3 | 0.440 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.440 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.440 | |
| 3ny9 | JSZ | Beta-2 adrenergic receptor | / | 0.440 |