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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2io6330Wee1-like protein kinase2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2io6330Wee1-like protein kinase2.7.10.21.000
2z2w770Wee1-like protein kinase2.7.10.20.819
2in6839Wee1-like protein kinase2.7.10.20.766
3biz61EWee1-like protein kinase2.7.10.20.715
3cqeP91Wee1-like protein kinase2.7.10.20.680
1x8b824Wee1-like protein kinase2.7.10.20.651
3cr0809Wee1-like protein kinase2.7.10.20.638
3bi6396Wee1-like protein kinase2.7.10.20.607
2yac937Serine/threonine-protein kinase PLK12.7.11.210.543
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.523
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.518
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.504
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.503
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.501
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.496
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.494
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.494
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.492
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.491
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.488
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.486
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.486
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.482
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.481
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.479
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.479
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.479
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.478
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.478
3zewSTUEphrin type-B receptor 42.7.10.10.477
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.476
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.476
3d5wADPSerine/threonine-protein kinase PLK/0.475
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.475
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.469
2yn8STUEphrin type-B receptor 42.7.10.10.468
3zep1NXTyrosine-protein kinase JAK32.7.10.20.468
2owb626Serine/threonine-protein kinase PLK12.7.11.210.467
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.466
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.465
1yvj4STTyrosine-protein kinase JAK32.7.10.20.464
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.463
4e4m0NHTyrosine-protein kinase JAK2/0.462
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.462
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.460
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.460
4hvh19RTyrosine-protein kinase JAK32.7.10.20.460
3zh8C58Protein kinase C iota type2.7.11.130.458
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.457
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.457
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.457
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.456
4bfwZVWPantothenate kinase2.7.1.330.456
4wkqIREEpidermal growth factor receptor2.7.10.10.456
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.455
2x9vTMQPteridine reductase/0.454
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.454
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.452
4grb0XGCasein kinase II subunit alpha2.7.11.10.452
2ph5NADHomospermidine synthase/0.451
2zsdCOAPantothenate kinase2.7.1.330.450
4iarERM5-hydroxytryptamine receptor 1B/0.450
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.450
4f1oACPProbable serine/threonine-protein kinase roco42.7.11.10.448
4fnyI3KALK tyrosine kinase receptor2.7.10.10.448
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.447
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.447
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
4bftZVTPantothenate kinase2.7.1.330.447
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.447
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.446
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.446
4qnaX11Serine/threonine-protein kinase 242.7.11.10.446
3reyXACAdenosine receptor A2a/0.446
2itpAEEEpidermal growth factor receptor2.7.10.10.445
2j7t274Serine/threonine-protein kinase 102.7.11.10.445
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
4bfvZVVPantothenate kinase2.7.1.330.444
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.444
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.444
4riyADPEpidermal growth factor receptor2.7.10.10.444
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.443
1eh4IC1Casein kinase I homolog 12.7.11.10.442
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.442
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.442
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.442
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.442
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.440
4jq7KJQEpidermal growth factor receptor2.7.10.10.440
4jq8KJ8Epidermal growth factor receptor2.7.10.10.440