Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2iki388Aldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2iki388Aldose reductase1.1.1.211.000
1z8962PAldose reductase1.1.1.210.762
2pdmZSTAldose reductase1.1.1.210.756
1t40ID5Aldose reductase1.1.1.210.750
2fz8ZSTAldose reductase1.1.1.210.735
2ikj393Aldose reductase1.1.1.210.688
3ld5LDTAldose reductase1.1.1.210.675
1z3n3NAAldose reductase1.1.1.210.668
2i16LDTAldose reductase1.1.1.210.666
3ghrLDTAldose reductase1.1.1.210.661
2dv0ZSTAldose reductase1.1.1.210.644
2pdiZSTAldose reductase1.1.1.210.643
4gca2X9Aldose reductase1.1.1.210.641
2duzZSTAldose reductase1.1.1.210.636
1t41ID5Aldose reductase1.1.1.210.626
2fz9ZSTAldose reductase1.1.1.210.626
3ghsLDTAldose reductase1.1.1.210.626
2ikhLITAldose reductase1.1.1.210.625
2qxwLDTAldose reductase1.1.1.210.612
2duxZSTAldose reductase1.1.1.210.608
3lqlLDTAldose reductase1.1.1.210.607
3lboLDTAldose reductase1.1.1.210.606
3lenZSTAldose reductase1.1.1.210.606
3m4h388Aldose reductase1.1.1.210.606
3mb9ZSTAldose reductase1.1.1.210.606
2i17LDTAldose reductase1.1.1.210.602
3ghtLDTAldose reductase1.1.1.210.602
1pwlBFIAldose reductase1.1.1.210.599
2pdfZSTAldose reductase1.1.1.210.596
2hv5ZSTAldose reductase1.1.1.210.595
3m64393Aldose reductase1.1.1.210.595
2pdp393Aldose reductase1.1.1.210.592
2pdxZSTAldose reductase1.1.1.210.586
3g5eQ74Aldose reductase1.1.1.210.585
2pdh47DAldose reductase1.1.1.210.582
2pdu393Aldose reductase1.1.1.210.582
2pdc393Aldose reductase1.1.1.210.577
3mc5393Aldose reductase1.1.1.210.577
2pdg47DAldose reductase1.1.1.210.569
1ieiZESAldose reductase1.1.1.210.568
2pzn393Aldose reductase1.1.1.210.566
3lz5LDTAldose reductase1.1.1.210.565
3ghuLDTAldose reductase1.1.1.210.557
2pdbZSTAldose reductase1.1.1.210.553
1us0LDTAldose reductase1.1.1.210.551
2pdlTOLAldose reductase1.1.1.210.549
3t423T4Aldose reductase1.1.1.210.549
2hvnZSTAldose reductase1.1.1.210.547
3m0iZSTAldose reductase1.1.1.210.547
2pd5ZSTAldose reductase1.1.1.210.546
2pdwFIDAldose reductase1.1.1.210.546
2iqdLPAAldose reductase1.1.1.210.545
2pdj393Aldose reductase1.1.1.210.544
2pdn47DAldose reductase1.1.1.210.542
1frbZSTAldose reductase-related protein 2/0.540
1zuaTOLAldo-keto reductase family 1 member B101.1.10.536
4yu153NAldose reductase1.1.1.210.535
2inzOHPAldose reductase1.1.1.210.534
2agtFIDAldose reductase1.1.1.210.533
2fzdTOLAldose reductase1.1.1.210.533
2hvoZSTAldose reductase1.1.1.210.533
2pdq47DAldose reductase1.1.1.210.520
1ah3TOLAldose reductase1.1.1.210.500
2f2kTGGAldose reductase1.1.1.210.486
3f3y4OABile salt sulfotransferase2.8.2.140.482
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.482
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.480
5liu388Aldo-keto reductase family 1 member B101.1.10.477
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.474
3n0hTOPDihydrofolate reductase1.5.1.30.474
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
1ry0PG2Aldo-keto reductase family 1 member C3/0.472
2pdyFIDAldose reductase1.1.1.210.472
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.472
3v35NTIAldose reductase1.1.1.210.471
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.471
4li61XOTankyrase-12.4.2.300.471
1el3I84Aldose reductase1.1.1.210.463
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.463
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.463
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
4dbw511Aldo-keto reductase family 1 member C3/0.461
4e0u0MVCyclic dipeptide N-prenyltransferase/0.461
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2f3815MAldo-keto reductase family 1 member C3/0.459
4u163C0Muscarinic acetylcholine receptor M3/0.459
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.458
4phlPILPhosphodiesterase/0.458
2cekN8TAcetylcholinesterase3.1.1.70.457
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.457
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3u2cSUZAldose reductase1.1.1.210.456
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.456
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.455
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.455
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.455
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2aovC2MHistamine N-methyltransferase2.1.1.80.454
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.454
1c7oPPGHemolysin/0.453
2aouCQAHistamine N-methyltransferase2.1.1.80.453
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.453
4bftZVTPantothenate kinase2.7.1.330.453
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.453
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.453
1s9dAFBCytohesin-2/0.452
1s9dAFBADP-ribosylation factor 1/0.452
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3t0kDCQSulfide-quinone reductase/0.452
3w2eFADNADH-cytochrome b5 reductase 31.6.2.20.452
4hcy0YNTransketolase/0.452
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.451
2nvcITAAldose reductase1.1.1.210.451
1lkeDOGBilin-binding protein/0.450
1ry8RUTAldo-keto reductase family 1 member C3/0.450
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3s3gTLTAldose reductase1.1.1.210.449
1esmCOAPantothenate kinase2.7.1.330.448
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.448
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3uweVJJAldo-keto reductase family 1 member C3/0.448
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.448
4bfuZVUPantothenate kinase2.7.1.330.448
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
1pkfEPDEpothilone C/D epoxidase1.140.447
1x8lOXRRetinol dehydratase/0.447
2aot2PMHistamine N-methyltransferase2.1.1.80.447
2fzbTOLAldose reductase1.1.1.210.447
2qimZEAClass 10 plant pathogenesis-related protein/0.447
2xuhTZ4Acetylcholinesterase3.1.1.70.447
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.447
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.447
1ekoI84Aldose reductase1.1.1.210.446
1lnmDTXBilin-binding protein/0.446
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3iu9T07Methionine aminopeptidase 2/0.446
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
4q0kGA3Phytohormone-binding protein/0.446
1zgbA1EAcetylcholinesterase3.1.1.70.445
3c1oNAPEugenol synthase/0.445
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.444
2cbqTH2Neocarzinostatin/0.444
2gvcFADThiol-specific monooxygenase1.14.130.444
4ga8SBIAldo-keto reductase family 1 member B101.1.10.444
4wevSUZAldo-keto reductase family 1 member B101.1.10.444
4xwtU5PRibonuclease J/0.444
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.443
2jb4A14Isopenicillin N synthase1.21.3.10.443
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.443
1xf0ASDAldo-keto reductase family 1 member C3/0.442
1yw7A41Methionine aminopeptidase 2/0.442
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.442
2ct8MSPMethionine--tRNA ligase6.1.1.100.441
2xupTZ5Acetylcholinesterase3.1.1.70.441
4es5MGTPolymerase basic protein 2/0.441
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
5stdUNNScytalone dehydratase4.2.1.940.441
2v0mKLNCytochrome P450 3A4/0.440
2xlpNAPPutative flavin-containing monooxygenase/0.440
3d2dRENReticuline oxidase1.21.3.30.440
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3r8hZOMAldo-keto reductase family 1 member C3/0.440