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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ijmATPFocal adhesion kinase 12.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ijmATPFocal adhesion kinase 12.7.10.21.000
2j0lANPFocal adhesion kinase 12.7.10.20.527
3pxkPXKFocal adhesion kinase 12.7.10.20.510
5l8lADPAurora kinase A2.7.11.10.509
2henADPEphrin type-B receptor 22.7.10.10.504
1i44ACPInsulin receptor2.7.10.10.492
2qoqANPEphrin type-A receptor 32.7.10.10.483
2wqeADPAurora kinase A2.7.11.10.479
2ijmADPFocal adhesion kinase 12.7.10.20.478
4c3pACPAurora kinase A2.7.11.10.478
4o0uADNAurora kinase A2.7.11.10.478
3t8oATPRhodopsin kinase/0.472
3c4xATPRhodopsin kinase/0.470
4l9i8PRRhodopsin kinase/0.465
3c4wATPRhodopsin kinase/0.462
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.458
2etm7PYFocal adhesion kinase 12.7.10.20.457
5dosATPAurora kinase A2.7.11.10.457
4jia1K3Tyrosine-protein kinase JAK2/0.456
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.456
2w1fL0FAurora kinase A2.7.11.10.454
2qo7ANPEphrin type-A receptor 32.7.10.10.452
4j99ACPFibroblast growth factor receptor 2/0.452
1pmn984Mitogen-activated protein kinase 102.7.11.240.451
4qmlANPSerine/threonine-protein kinase 242.7.11.10.451
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.449
2bfyH1NAurora kinase B-A2.7.11.10.448
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.445
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.445
3c4zADPRhodopsin kinase/0.444
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
2j0m4STFocal adhesion kinase 12.7.10.20.441
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.440
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.440