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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ii6C5PAlpha-2,3/2,6-sialyltransferase/sialidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ii6C5PAlpha-2,3/2,6-sialyltransferase/sialidase/1.000
2iiqC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.539
3f03FMNPentaerythritol tetranitrate reductase/0.482
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.480
1h63FMNPentaerythritol tetranitrate reductase/0.477
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.472
1h50FMNPentaerythritol tetranitrate reductase/0.469
1h51FMNPentaerythritol tetranitrate reductase/0.468
1vyrFMNPentaerythritol tetranitrate reductase/0.466
2gjlFMNNitronate monooxygenase1.13.12.160.466
2abbFMNPentaerythritol tetranitrate reductase/0.465
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.465
4dx7DM2Multidrug efflux pump subunit AcrB/0.460
1h74AGSHomoserine kinase2.7.1.390.459
2v58LZJBiotin carboxylase6.3.4.140.459
3q9bB3NAcetylpolyamine amidohydrolase/0.459
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.458
1qwjNCCN-acylneuraminate cytidylyltransferase2.7.7.430.455
1r6tTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.455
2e1zB4PPropionate kinase/0.455
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.455
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.455
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.453
2xpuTDCTetracycline repressor protein class D/0.453
4gdcNDPUDP-galactopyranose mutase/0.453
4p63NADProbable deoxyhypusine synthase2.5.1.460.453
2iyfERYOleandomycin glycosyltransferase2.4.10.452
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.451
2f3rG5PGuanylate kinase2.7.4.80.449
4jicFMNGTN Reductase/0.447
4yj2GTPTubulin alpha-1B chain/0.447
2zsaADPPantothenate kinase2.7.1.330.446
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.445
4m83ERYOleandomycin glycosyltransferase2.4.10.445
2bn4FMNNADPH--cytochrome P450 reductase/0.444
3hyoADPPyridoxal kinase/0.443
3p82FMNPentaerythritol tetranitrate reductase/0.443
3pdqKC6Lysine-specific demethylase 4A1.14.110.443
4gddNAIUDP-galactopyranose mutase/0.443
5d3qGDPDynamin-13.6.5.50.443
3tr05GPGuanylate kinase/0.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3c34KAIGlutamate receptor ionotropic, kainate 1/0.441
3c35KAIGlutamate receptor ionotropic, kainate 1/0.441
1e3eNAIAlcohol dehydrogenase 41.1.1.10.440
2vkeTACTetracycline repressor protein class D/0.440
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.440
4djaFAD(6-4) photolyase/0.440
4r81FMNPredicted NADH dehydrogenase/0.440