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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ic3HBYGag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ic3HBYGag-Pol polyprotein2.7.7.491.000
1hquHBYGag-Pol polyprotein2.7.7.490.563
3i0rRT3Gag-Pol polyprotein2.7.7.490.539
3dmjGWEPol protein/0.521
1rt2TNKGag-Pol polyprotein2.7.7.490.520
3ffi3OBGag-Pol polyprotein2.7.7.490.519
1tvrTB9Gag-Pol polyprotein2.7.7.490.518
1hpzAAPGag-Pol polyprotein2.7.7.490.502
4uymVOR14-alpha sterol demethylase Cyp51B/0.500
1jlaTNKGag-Pol polyprotein2.7.7.490.498
2hcdBIVVitamin D3 receptor A/0.498
4i2q1BTGag-Pol polyprotein2.7.7.490.493
1xuoLA1Integrin alpha-L/0.492
4ia2BIVVitamin D3 receptor A/0.490
3dleGFAGag-Pol polyprotein2.7.7.490.489
4i7fNVEGag-Pol polyprotein2.7.7.490.488
4ruoBIVVitamin D3 receptor A/0.488
1rtiHEFGag-Pol polyprotein2.7.7.490.487
3i0sRT7Gag-Pol polyprotein2.7.7.490.487
3stxBKAMethylketone synthase I/0.485
4ia7BIVVitamin D3 receptor A/0.483
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.481
1q5dEPBEpothilone C/D epoxidase1.140.476
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.476
3syiFADSulfide-quinone reductase/0.476
1hnvTBOGag-Pol polyprotein2.7.7.490.473
3p99LNPLanosterol 14-alpha-demethylase/0.473
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.473
3a60STURibosomal protein S6 kinase beta-12.7.11.10.472
3di6PDZGag-Pol polyprotein2.7.7.490.472
3kpkFADSulfide-quinone reductase/0.472
3ce31FNHepatocyte growth factor receptor2.7.10.10.471
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.471
3s79ASDAromatase1.14.14.140.471
3t2zFADSulfide-quinone reductase/0.471
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/0.470
3drrR8EGag-Pol polyprotein2.7.7.490.470
3sz0FADSulfide-quinone reductase/0.470
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.470
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.469
3t14FADSulfide-quinone reductase/0.469
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.469
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.468
4ib4ERM5-hydroxytryptamine receptor 2B/0.468
4nc3ERM5-hydroxytryptamine receptor 2B/0.468
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.468
1tkzH16Gag-Pol polyprotein2.7.7.490.467
3abaFLICytochrome P450/0.467
3t2yFADSulfide-quinone reductase/0.467
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.467
1c1bGCAGag-Pol polyprotein2.7.7.490.466
1vruAAPGag-Pol polyprotein2.7.7.490.466
3gc9B45Mitogen-activated protein kinase 112.7.11.240.465
3lamKRPGag-Pol polyprotein2.7.7.490.465
3vt8YI3Vitamin D3 receptor/0.465
4rupH97Vitamin D3 receptor A/0.465
1s1vTNKGag-Pol polyprotein2.7.7.490.464
1w2xRCPAcetyl-CoA carboxylase/0.464
1xddAAYIntegrin alpha-L/0.464
4g3jVNTLanosterol 14-alpha-demethylase/0.464
4q5hANPProtein kinase OspG2.70.464
1c1c612Gag-Pol polyprotein2.7.7.490.463
1eh4IC1Casein kinase I homolog 12.7.11.10.463
2q59240Peroxisome proliferator-activated receptor gamma/0.463
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.462
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.462
3vt5YI2Vitamin D3 receptor/0.462
1s9eADBGag-Pol polyprotein2.7.7.490.461
3wv9FEGHmd co-occurring protein HcgE/0.461
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.461
4jlj1NMDeoxycytidine kinase2.7.1.740.461
2vn0TDZCytochrome P450 2C8/0.460
3drcMTXDihydrofolate reductase1.5.1.30.460
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.460
1fm9570Peroxisome proliferator-activated receptor gamma/0.459
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.459
4fkv61KCyclin-dependent kinase 22.7.11.220.459
4iarERM5-hydroxytryptamine receptor 1B/0.459
5hs1VORLanosterol 14-alpha demethylase/0.459
3och2MXDihydrofolate reductase1.5.1.30.458
3vt7VDXVitamin D3 receptor/0.458
3zcw4A2Kinesin-like protein KIF11/0.458
5cyqT27Gag-Pol polyprotein2.7.7.490.458
1revTB9Gag-Pol polyprotein2.7.7.490.457
3dolGWIPol protein/0.457
3gcoVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.457
4y8wSTRSteroid 21-hydroxylase/0.457
1hniAAAGag-Pol polyprotein2.7.7.490.456
1bygSTUTyrosine-protein kinase CSK/0.455
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.455
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.455
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.455
1y4sADPChaperone protein HtpG/0.454
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.454
2j14GNIPeroxisome proliferator-activated receptor delta/0.454
2xd6XD6ATP-dependent molecular chaperone HSP82/0.454
4d7eFADPutative lysine-N-oxygenase/0.454
4jlk1NODeoxycytidine kinase2.7.1.740.454
4loqSB4Mitogen-activated protein kinase 14/0.454
1kkq471Peroxisome proliferator-activated receptor alpha/0.453
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.453
2uxpCLMHTH-type transcriptional regulator TtgR/0.453
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.453
3lu6IMXSerum albumin/0.453
3nga3NGCasein kinase II subunit alpha2.7.11.10.453
3t2kFADSulfide-quinone reductase/0.453
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
1cqp803Integrin alpha-L/0.452
1g1aNADdTDP-glucose 4,6-dehydratase/0.452
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3a1l2CCCytochrome P450/0.452
3nbpJGZGag-Pol polyprotein2.7.7.490.452
3p6oETGCamphor 5-monooxygenase1.14.15.10.452
4ipw1G7Mycocyclosin synthase1.14.21.90.452
4kko1REGag-Pol polyprotein2.7.7.490.452
1rt1MKCGag-Pol polyprotein2.7.7.490.451
2ovhAS0Progesterone receptor/0.451
2q5g1FAPeroxisome proliferator-activated receptor delta/0.451
2vnhFADNADPH:ferredoxin reductase/0.451
2w98P1ZProstaglandin reductase 21.3.1.480.451
2wpwACOOrf14/0.451
3lanKBTGag-Pol polyprotein2.7.7.490.451
3lshFADPyranose 2-oxidase/0.451
4g7gVFVLanosterol 14-alpha-demethylase/0.451
4nb6444Nuclear receptor ROR-gamma/0.451
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.451
1eetBFUGag-Pol polyprotein2.7.7.490.450
1rt5UC2Gag-Pol polyprotein2.7.7.490.450
2bu9HFVIsopenicillin N synthase1.21.3.10.450
2dteNAIGlucose 1-dehydrogenase related protein/0.450
2ovmAS0Progesterone receptor/0.450
3adaNADSubunit alpha of sarocosine oxidase/0.450
3p3zP3ZPutative cytochrome P450/0.450
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.450
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.450
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.450
4hee14RPeroxisome proliferator-activated receptor gamma/0.450
4ia3BIVVitamin D3 receptor A/0.450
4xldBRLPeroxisome proliferator-activated receptor gamma/0.450
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.449
2p4yC03Peroxisome proliferator-activated receptor gamma/0.449
3pgqGY3Acetyl-CoA carboxylase/0.449
4ez50RSCyclin-dependent kinase 62.7.11.220.449
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.449
6coxS58Prostaglandin G/H synthase 21.14.99.10.449
1fmjRTLRetinol dehydratase/0.448
1knuYPAPeroxisome proliferator-activated receptor gamma/0.448
1u2oNECEndoplasmin/0.448
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.448
2cig1DGDihydrofolate reductase1.5.1.30.448
2gtk208Peroxisome proliferator-activated receptor gamma/0.448
2rkiTT1Gag-Pol polyprotein2.7.7.490.448
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.448
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.448
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3hekBD0Heat shock protein HSP 90-alpha/0.448
3nr4PYVAbscisic acid receptor PYL2/0.448
3slkNDPPolyketide synthase extender module 2/0.448
3ua506XCytochrome P450 2B61.14.130.448
4a802ANMajor pollen allergen Bet v 1-A/0.448
4iq71G9Mycocyclosin synthase1.14.21.90.448
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.448
1eioGCHGastrotropin/0.447
1lf3EH5Plasmepsin-23.4.23.390.447
1phgMYTCamphor 5-monooxygenase1.14.15.10.447
1uumAFIDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.447
3is9AC7Gag-Pol polyprotein2.7.7.490.447
3tmz06XCytochrome P450 2B41.14.14.10.447
4e5yNDPGDP-L-fucose synthase1.1.1.2710.447
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.447
4isk1JYThymidylate synthase/0.447
1aq1STUCyclin-dependent kinase 22.7.11.220.446
1kzjCB3Thymidylate synthase/0.446
2aclREARetinoic acid receptor RXR-alpha/0.446
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.446
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.446
2zb3NDPProstaglandin reductase 21.3.1.480.446
2zjmF1MBeta-secretase 13.4.23.460.446
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.446
3t1a5MAGag-Pol polyprotein2.7.7.490.446
4b8zNAPGDP-L-fucose synthase1.1.1.2710.446
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2vcmM11Isopenicillin N synthase1.21.3.10.445
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.445
3d75NBBPheromone-binding protein ASP1/0.445
3iupNDPPossible NADH oxidoreductase/0.445
3oqkS52Renin3.4.23.150.445
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.445
4fkpLS5Cyclin-dependent kinase 22.7.11.220.445
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.445
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
1pkfEPDEpothilone C/D epoxidase1.140.444
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.444
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.444
2pobGW4Peroxisome proliferator-activated receptor gamma/0.444
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.444
3gdvTYR_GLN_PHESerine endoprotease DegS3.4.21.1070.444
3gw9VNILanosterol 14-alpha-demethylase/0.444
3iqeF42F420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.444
3linE13Protease/0.444
3p6pA6BCamphor 5-monooxygenase1.14.15.10.444
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.444
4ia1BIVVitamin D3 receptor A/0.444
4z34ON7Lysophosphatidic acid receptor 1/0.444
1ikxPNUGag-Pol polyprotein2.7.7.490.443
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1qy5NECEndoplasmin/0.443
1s19MC9Vitamin D3 receptor/0.443
1zemNADXylitol dehydrogenase/0.443
2w17I19Cyclin-dependent kinase 22.7.11.220.443
2wpxACOOrf14/0.443
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.443
3le62BZCyclin-dependent kinase 22.7.11.220.443
3r9oZ71Cyclin-dependent kinase 22.7.11.220.443
4ko0JLJGag-Pol polyprotein2.7.7.490.443
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.443
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.443
1errRALEstrogen receptor/0.442
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1iyzNDPProbable quinone oxidoreductase/0.442
1m13HYFNuclear receptor subfamily 1 group I member 2/0.442
1ndeMONEstrogen receptor beta/0.442
1nytNAPShikimate dehydrogenase (NADP(+))/0.442
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.442
2vnkFADNADPH:ferredoxin reductase/0.442
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3h0aD30Peroxisome proliferator-activated receptor gamma/0.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.442
3opdHIEHeat shock protein 83/0.442
3wxyCOAUncharacterized protein/0.442
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.442
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.442
4okx198Androgen receptor/0.442
4xumIMNPeroxisome proliferator-activated receptor gamma/0.442
5cnnANPEpidermal growth factor receptor2.7.10.10.442
5uviZMAAdenosine receptor A2a/0.442
3sn6P0GBeta-2 adrenergic receptor/0.442
1xucPB3Collagenase 33.4.240.441
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.441
2q5p241Peroxisome proliferator-activated receptor gamma/0.441
2q8sL92Peroxisome proliferator-activated receptor gamma/0.441
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.441
3livE16Protease/0.441
3own3OWRenin3.4.23.150.441
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.441
4e0iFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.441
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.441
4jazSTLPeroxisome proliferator-activated receptor gamma/0.441
4ktl1CQCytochrome P450/0.441
4uyf73BBromodomain-containing protein 2/0.441
1ep4S11Gag-Pol polyprotein2.7.7.490.440
1n4hREANuclear receptor ROR-beta/0.440
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
1yc2NADNAD-dependent protein deacylase 2/0.440
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.440
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.440
2xviFADPutative flavin-containing monooxygenase/0.440
3b6zCO7Enoyl reductase LovC10.440
4ips1G4Mycocyclosin synthase1.14.21.90.440
4r21STRCytochrome P450 family 17 polypeptide 2/0.440