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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.11.000
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.543
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.524
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.519
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.503
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.500
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.495
5e8wSTUTGF-beta receptor type-12.7.11.300.493
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.492
4riyADPEpidermal growth factor receptor2.7.10.10.492
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.491
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.490
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.486
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.485
4c02TAKActivin receptor type-12.7.11.300.484
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.483
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.482
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.482
4hni16WCasein kinase I isoform epsilon2.7.11.10.481
1u54ACPActivated CDC42 kinase 1/0.480
1rw8580TGF-beta receptor type-12.7.11.300.479
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.478
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.477
1bygSTUTyrosine-protein kinase CSK/0.475
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.475
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.475
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.474
1vjy460TGF-beta receptor type-12.7.11.300.474
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.474
3vs3VSETyrosine-protein kinase HCK2.7.10.20.474
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.473
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.473
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.472
3mtfA3FActivin receptor type-12.7.11.300.472
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.472
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.470
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.470
3beaIXHMacrophage colony-stimulating factor 1 receptor2.7.10.10.469
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.469
4i22IREEpidermal growth factor receptor2.7.10.10.469
4jq7KJQEpidermal growth factor receptor2.7.10.10.468
2vwx7X4Ephrin type-B receptor 42.7.10.10.467
2hk51BMTyrosine-protein kinase HCK2.7.10.20.466
2itnANPEpidermal growth factor receptor2.7.10.10.466
4dymIYZActivin receptor type-12.7.11.300.466
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.465
3vryB43Tyrosine-protein kinase HCK2.7.10.20.465
3vs1VSATyrosine-protein kinase HCK2.7.10.20.465
2wotZZGTGF-beta receptor type-12.7.11.300.464
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.464
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.464
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.463
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.463
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.462
3oom507Activin receptor type-12.7.11.300.462
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.461
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.461
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.461
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.460
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.460
3gxlQIGTGF-beta receptor type-12.7.11.300.460
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.460
3zze6XPHepatocyte growth factor receptor2.7.10.10.460
2vwu7X1Ephrin type-B receptor 42.7.10.10.459
4gk3L87Ephrin type-A receptor 32.7.10.10.459
4kiq1RAMitogen-activated protein kinase 14/0.459
1py5PY1TGF-beta receptor type-12.7.11.300.458
2vx17X8Ephrin type-B receptor 42.7.10.10.458
4c58824Cyclin-G-associated kinase2.7.11.10.458
5e92ANPTGF-beta receptor type-22.7.11.300.458
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
2qo9ANPEphrin type-A receptor 32.7.10.10.457
4c62XWWTyrosine-protein kinase JAK2/0.457
2vwy7X5Ephrin type-B receptor 42.7.10.10.456
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.456
3el4ROCGag-Pol polyprotein3.4.23.160.456
4hvh19RTyrosine-protein kinase JAK32.7.10.20.456
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.455
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.455
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.455
3ormAGSSerine/threonine protein kinase/0.455
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2ittAEEEpidermal growth factor receptor2.7.10.10.454
2of2547Tyrosine-protein kinase Lck2.7.10.20.454
5cvhADPCasein kinase II subunit alpha2.7.11.10.454
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.453
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.453
3l8xN4DMitogen-activated protein kinase 14/0.453
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.453
4hjoAQ4Epidermal growth factor receptor2.7.10.10.453
2bakAQZMitogen-activated protein kinase 14/0.452
2io6330Wee1-like protein kinase2.7.10.20.452
2y6o1N1Ephrin type-A receptor 42.7.10.10.452
3zewSTUEphrin type-B receptor 42.7.10.10.452
4a9yAQZMitogen-activated protein kinase 14/0.452
4jr3KJREpidermal growth factor receptor2.7.10.10.452
1m2rMNYCasein kinase II subunit alpha2.7.11.10.451
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.451
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.451
2vwz7X6Ephrin type-B receptor 42.7.10.10.451
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.451
2in6839Wee1-like protein kinase2.7.10.20.450
3a4pDFQHepatocyte growth factor receptor2.7.10.10.450
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.450
4bb432WEphrin type-B receptor 42.7.10.10.450
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.450
1xkkFMMEpidermal growth factor receptor2.7.10.10.449
2wouZZFTGF-beta receptor type-12.7.11.300.449
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.449
3zh8C58Protein kinase C iota type2.7.11.130.449
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4kb81QOCasein kinase I isoform delta2.7.11.10.448
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1h1s4SPCyclin-dependent kinase 22.7.11.220.447
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
2uzlC94Cyclin-dependent kinase 22.7.11.220.447
3hmm855TGF-beta receptor type-12.7.11.300.447
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.447
5e8xSTUTGF-beta receptor type-12.7.11.300.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.446
4gk2L66Ephrin type-A receptor 32.7.10.10.446
1u4dDBQActivated CDC42 kinase 1/0.445
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1z1rHBHGag-Pol polyprotein3.4.23.160.444
2qoqANPEphrin type-A receptor 32.7.10.10.444
3biz61EWee1-like protein kinase2.7.10.20.444
3kddJZQGag-Pol polyprotein3.4.23.160.444
3rvg17PTyrosine-protein kinase JAK2/0.444
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.444
4fnyI3KALK tyrosine kinase receptor2.7.10.10.444
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.444
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
5dpvSKEAurora kinase A2.7.11.10.444
1csnATPCasein kinase I homolog 12.7.11.10.443
1oiyN41Cyclin-dependent kinase 22.7.11.220.443
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.443
4cd0AWJALK tyrosine kinase receptor2.7.10.10.443
4hy6FJ1Heat shock protein HSP 90-alpha/0.443
4zseANPEpidermal growth factor receptor2.7.10.10.443
1m17AQ4Epidermal growth factor receptor2.7.10.10.442
1pkdUCNCyclin-dependent kinase 22.7.11.220.442
2ogiGDPUncharacterized protein/0.442
2xa4AZ5Tyrosine-protein kinase JAK2/0.442
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.442
4bgg844Activin receptor type-12.7.11.300.442
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.442
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
1aq1STUCyclin-dependent kinase 22.7.11.220.441
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.441
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2balPQAMitogen-activated protein kinase 14/0.441
3gu83GUDeath-associated protein kinase 12.7.11.10.441
3nszANPCasein kinase II subunit alpha2.7.11.10.441
3q9zTXQCasein kinase II subunit alpha2.7.11.10.441
3vjoANPEpidermal growth factor receptor2.7.10.10.441
3zsh469Mitogen-activated protein kinase 14/0.441
1oecAA2Fibroblast growth factor receptor 2/0.440
1qxoFMNChorismate synthase/0.440
2pvlP55Casein kinase II subunit alpha2.7.11.10.440
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
3c50ADPRhodopsin kinase/0.440
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4jq8KJ8Epidermal growth factor receptor2.7.10.10.440