sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 1.000 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.555 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.528 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.514 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.512 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.501 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.500 | |
| 2xyn | VX6 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.498 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.495 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.494 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.494 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.490 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.487 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.487 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.485 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.484 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.484 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.484 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.483 | |
| 1qpe | PP2 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.482 | |
| 3g0f | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.482 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.482 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.481 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.481 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.480 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.480 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.480 | |
| 3qri | 919 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.480 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.479 | |
| 1qvn | FRI | Interleukin-2 | / | 0.479 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.479 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.479 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.478 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.478 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.477 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.477 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.476 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.476 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.476 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.476 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.476 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.476 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.475 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.475 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.474 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.474 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.472 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.472 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.472 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.471 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.471 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.470 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.470 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.470 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.469 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.469 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.469 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.468 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.468 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.467 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.466 | |
| 5kj1 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.466 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.465 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.465 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.465 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.465 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.464 | |
| 3liq | E14 | Protease | / | 0.464 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.463 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.463 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.463 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.463 | |
| 3t9i | 3T9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.463 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.463 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.463 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.463 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.463 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.462 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.462 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.462 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.462 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.462 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.462 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.462 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.461 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.461 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.461 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.461 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 2ol4 | JPN | Enoyl-ACP reductase | / | 0.460 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.460 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.460 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.460 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.460 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.459 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.459 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.459 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.459 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.459 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.459 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.459 | |
| 4b8m | VX6 | Aurora kinase B-A | 2.7.11.1 | 0.459 | |
| 4l9q | 9TP | Serum albumin | / | 0.459 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.458 | |
| 2bb9 | AKC | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.458 | |
| 2i1m | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.458 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.458 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.458 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.458 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 4cnj | FAD | L-amino acid oxidase | / | 0.458 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.458 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.457 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.457 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2qu5 | 276 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.457 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.457 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.457 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.457 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.457 | |
| 4pd6 | URI | Nucleoside permease | / | 0.457 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.457 | |
| 5cds | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.457 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.456 | |
| 2qu6 | 857 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.456 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.456 | |
| 3up3 | XCA | aceDAF-12 | / | 0.456 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.456 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.456 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.455 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.455 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.455 | |
| 3ad6 | KSC | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.455 | |
| 3g0e | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.455 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.455 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.455 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.455 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.455 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.455 | |
| 1ppj | ANY | Cytochrome b | / | 0.454 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.454 | |
| 2zv9 | PP2 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.454 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.454 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.454 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.454 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.454 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.453 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.453 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.453 | |
| 3c5u | P41 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.453 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.453 | |
| 3vry | B43 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.453 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.453 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.453 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.453 | |
| 4n6b | COA | Uncharacterized protein | / | 0.453 | |
| 5dp2 | NAP | CurF | / | 0.453 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.453 | |
| 1s7n | COA | Acetyl transferase | / | 0.452 | |
| 1swt | BTN | Streptavidin | / | 0.452 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.452 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 3liv | E16 | Protease | / | 0.452 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.452 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.452 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.452 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.452 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.451 | |
| 2ji6 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.451 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.451 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.451 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.451 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.451 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.451 | |
| 1bdr | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1fbm | RTL | Cartilage oligomeric matrix protein | / | 0.450 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1msn | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.450 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.450 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.450 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.450 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.450 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.450 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 4nfh | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 5dt0 | SKE | Aurora kinase A | 2.7.11.1 | 0.450 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.450 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.449 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.449 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.449 | |
| 3w2c | N15 | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 3zk6 | H1I | Bcl-2-like protein 1 | / | 0.449 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.449 | |
| 5cdg | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.449 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.449 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.448 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 2of4 | 979 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.448 | |
| 2zyb | KSL | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.448 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.448 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.448 | |
| 4agc | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.447 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 2gzw | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.447 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.447 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.447 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.447 | |
| 3nfa | CBJ | Gag-Pol polyprotein | / | 0.447 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.447 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.447 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 4l8u | 9AZ | Serum albumin | / | 0.447 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.446 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.446 | |
| 1zdw | FLV | Prenyltransferase | / | 0.446 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.446 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.446 | |
| 2jdv | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.446 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.446 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.446 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.446 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.446 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.446 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.446 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.446 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.446 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.445 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.445 | |
| 1i6x | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.445 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.445 | |
| 1osv | CHC | Bile acid receptor | / | 0.445 | |
| 2c7g | FAD | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.445 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.445 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.445 | |
| 3iup | NDP | Possible NADH oxidoreductase | / | 0.445 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.445 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.445 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.445 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 4fst | HK4 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4i5h | G17 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 4kxn | 6K6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.445 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.444 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.444 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.444 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.444 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.444 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.444 | |
| 2pzp | ACP | Fibroblast growth factor receptor 2 | / | 0.444 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 3up0 | D7S | aceDAF-12 | / | 0.444 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.444 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.444 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.444 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 4njt | 017 | Protease | / | 0.444 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.444 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 5cdt | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.444 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 1v5e | FAD | Pyruvate oxidase | / | 0.443 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.443 | |
| 1yol | S03 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.443 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.443 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.443 | |
| 3iw7 | IPK | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3stx | BKA | Methylketone synthase I | / | 0.443 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.443 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.443 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.443 | |
| 4mlh | VO2 | Glucokinase | 2.7.1.2 | 0.443 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.443 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.443 | |
| 5a3b | APR | SIR2 family protein | / | 0.443 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.442 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.442 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.442 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.442 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 2f8g | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2yir | YIR | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2yyy | NAP | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.59 | 0.442 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.442 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.442 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 5c3z | ACP | Ribokinase | / | 0.442 | |
| 1c6y | MK1 | Protease | / | 0.441 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.441 | |
| 1nde | MON | Estrogen receptor beta | / | 0.441 | |
| 1nq2 | 4HY | Thyroid hormone receptor beta | / | 0.441 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.441 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.441 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.441 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.441 | |
| 2vx1 | 7X8 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.441 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.441 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.441 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3suf | SUE | Polyprotein | / | 0.441 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.441 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 4lgg | VGG | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.441 | |
| 1b6k | PI5 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.440 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.440 | |
| 2oby | NAP | Quinone oxidoreductase PIG3 | 1 | 0.440 | |
| 2w4i | VGA | Glutamate racemase | / | 0.440 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3fmk | FMK | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.440 | |
| 3lby | SAH | Uncharacterized protein | / | 0.440 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.440 | |
| 3r5z | F42 | Uncharacterized protein | / | 0.440 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.440 | |
| 4ag8 | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 4c4j | X21 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.440 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.440 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.440 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 | |
| 4zoh | MCN | Putative oxidoreductase molybdopterin-binding subunit | / | 0.440 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.440 | |
| 5kcp | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.440 |