Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hyySTITyrosine-protein kinase ABL12.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hyySTITyrosine-protein kinase ABL12.7.10.21.000
1iepSTITyrosine-protein kinase ABL12.7.10.20.634
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.557
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.550
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.536
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.530
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.526
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.525
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.511
4o2z046Mitogen-activated protein kinase/0.508
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.499
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.497
2og81N8Tyrosine-protein kinase Lck2.7.10.20.488
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.477
3efl706Vascular endothelial growth factor receptor 22.7.10.10.471
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.470
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.456
3hv5R24Mitogen-activated protein kinase 14/0.448
3hng8STVascular endothelial growth factor receptor 12.7.10.10.444