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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hvoZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hvoZSTAldose reductase1.1.1.211.000
2hvnZSTAldose reductase1.1.1.210.680
2fz8ZSTAldose reductase1.1.1.210.667
3m64393Aldose reductase1.1.1.210.654
3ghrLDTAldose reductase1.1.1.210.650
2pdiZSTAldose reductase1.1.1.210.646
3ghsLDTAldose reductase1.1.1.210.646
2dv0ZSTAldose reductase1.1.1.210.644
3ghuLDTAldose reductase1.1.1.210.639
1z3n3NAAldose reductase1.1.1.210.633
2duxZSTAldose reductase1.1.1.210.629
2pdg47DAldose reductase1.1.1.210.624
1us0LDTAldose reductase1.1.1.210.619
2pdbZSTAldose reductase1.1.1.210.619
3ghtLDTAldose reductase1.1.1.210.619
2pdxZSTAldose reductase1.1.1.210.616
3g5eQ74Aldose reductase1.1.1.210.616
2i17LDTAldose reductase1.1.1.210.613
2pdfZSTAldose reductase1.1.1.210.609
2duzZSTAldose reductase1.1.1.210.608
3mc5393Aldose reductase1.1.1.210.606
2pdh47DAldose reductase1.1.1.210.603
3mb9ZSTAldose reductase1.1.1.210.603
3m0iZSTAldose reductase1.1.1.210.599
3ld5LDTAldose reductase1.1.1.210.598
2hv5ZSTAldose reductase1.1.1.210.597
3lz5LDTAldose reductase1.1.1.210.597
4yu153NAldose reductase1.1.1.210.597
2fz9ZSTAldose reductase1.1.1.210.596
2pzn393Aldose reductase1.1.1.210.595
2pd5ZSTAldose reductase1.1.1.210.592
2pdn47DAldose reductase1.1.1.210.588
3lenZSTAldose reductase1.1.1.210.586
2pdmZSTAldose reductase1.1.1.210.582
1pwlBFIAldose reductase1.1.1.210.576
2ikj393Aldose reductase1.1.1.210.576
4gca2X9Aldose reductase1.1.1.210.576
2qxwLDTAldose reductase1.1.1.210.568
2i16LDTAldose reductase1.1.1.210.565
3t423T4Aldose reductase1.1.1.210.563
2pdlTOLAldose reductase1.1.1.210.559
1frbZSTAldose reductase-related protein 2/0.555
2pdj393Aldose reductase1.1.1.210.555
3lboLDTAldose reductase1.1.1.210.552
3m4h388Aldose reductase1.1.1.210.551
2pdp393Aldose reductase1.1.1.210.550
2pdu393Aldose reductase1.1.1.210.549
2pdc393Aldose reductase1.1.1.210.542
2fzdTOLAldose reductase1.1.1.210.541
2ikhLITAldose reductase1.1.1.210.530
3lqlLDTAldose reductase1.1.1.210.525
1t41ID5Aldose reductase1.1.1.210.522
1ieiZESAldose reductase1.1.1.210.521
1zuaTOLAldo-keto reductase family 1 member B101.1.10.518
1el3I84Aldose reductase1.1.1.210.504
2pdq47DAldose reductase1.1.1.210.499
2iki388Aldose reductase1.1.1.210.496
1t40ID5Aldose reductase1.1.1.210.482
1z8962PAldose reductase1.1.1.210.481
1ah3TOLAldose reductase1.1.1.210.472
1ekoI84Aldose reductase1.1.1.210.472
2pdkSBIAldose reductase1.1.1.210.469
4bj9UHBTankyrase-22.4.2.300.468
4gabFIDAldo-keto reductase family 1 member B101.1.10.464
2pdyFIDAldose reductase1.1.1.210.462
1ry0PG2Aldo-keto reductase family 1 member C3/0.459
1pwmFIDAldose reductase1.1.1.210.458
1ef3FIDAldose reductase1.1.1.210.456
1u65CP0Acetylcholinesterase3.1.1.70.456
2aovC2MHistamine N-methyltransferase2.1.1.80.456
2f3815MAldo-keto reductase family 1 member C3/0.456
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.456
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.456
4wevSUZAldo-keto reductase family 1 member B101.1.10.456
2fzbTOLAldose reductase1.1.1.210.453
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.453
2pdwFIDAldose reductase1.1.1.210.450
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.450
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.450
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.449
4hyf1AKTankyrase-22.4.2.300.449
1ry8RUTAldo-keto reductase family 1 member C3/0.448
2inzOHPAldose reductase1.1.1.210.448
3s3gTLTAldose reductase1.1.1.210.448
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.448
4li61XOTankyrase-12.4.2.300.447
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.446
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2v0mKLNCytochrome P450 3A4/0.445
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
4ga8SBIAldo-keto reductase family 1 member B101.1.10.445
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.444
4jt91NSNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.443
2qimZEAClass 10 plant pathogenesis-related protein/0.442
4xwtU5PRibonuclease J/0.442
1dghNDPCatalase1.11.1.60.441
2cekN8TAcetylcholinesterase3.1.1.70.441
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.441
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.441
4dbuBT9Aldo-keto reductase family 1 member C3/0.440
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.440
2y0468HBeta-1 adrenergic receptor/0.440
4u140HKMuscarinic acetylcholine receptor M3/0.440