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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hs8FMN12-oxophytodienoate reductase 31.3.1.42

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hs8FMN12-oxophytodienoate reductase 31.3.1.421.000
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.654
1q45FMN12-oxophytodienoate reductase 31.3.1.420.641
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.634
1icpFMN12-oxophytodienoate reductase 11.3.1.420.626
1icqFMN12-oxophytodienoate reductase 11.3.1.420.623
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.599
3f03FMNPentaerythritol tetranitrate reductase/0.599
1icsFMN12-oxophytodienoate reductase 11.3.1.420.592
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.588
4tmbFMNOld yellow enzyme/0.581
2abbFMNPentaerythritol tetranitrate reductase/0.575
3p74FMNPentaerythritol tetranitrate reductase/0.570
1h50FMNPentaerythritol tetranitrate reductase/0.567
1h63FMNPentaerythritol tetranitrate reductase/0.563
1vyrFMNPentaerythritol tetranitrate reductase/0.561
2q3oFMN12-oxophytodienoate reductase 31.3.1.420.561
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.555
3p82FMNPentaerythritol tetranitrate reductase/0.550
3p62FMNPentaerythritol tetranitrate reductase/0.545
4jicFMNGTN Reductase/0.542
4rnuFMNNADPH dehydrogenase 11.6.99.10.538
4rnvFMNNADPH dehydrogenase 11.6.99.10.538
3p67FMNPentaerythritol tetranitrate reductase/0.536
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.531
1h51FMNPentaerythritol tetranitrate reductase/0.529
4e2dFMNDehydrogenase/0.525
3atzFMNProstaglandin F2a synthase/0.515
3p84FMNPentaerythritol tetranitrate reductase/0.510
4rnwFMNNADPH dehydrogenase 11.6.99.10.510
4e2bFMNDehydrogenase/0.498
3atyFMNProstaglandin F2a synthase/0.497
3l5lFMNXenobiotic reductase/0.497
3gkaFMNN-ethylmaleimide reductase/0.496
3p8jFMNPentaerythritol tetranitrate reductase/0.493
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.483
1bwlFMNNADPH dehydrogenase 11.6.99.10.478
3n19FNRXenobiotic reductase/0.478
3p8iFMNPentaerythritol tetranitrate reductase/0.478
1bwkFMNNADPH dehydrogenase 11.6.99.10.477
4awtFMNNADH:flavin oxidoreductase Sye1/0.475
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.474
4df2FMNNADPH dehydrogenase/0.474
1oyaFMNNADPH dehydrogenase 11.6.99.10.469
4tmcFMNOld yellow enzyme/0.468
4m5pFMNNADPH dehydrogenase/0.467
1z44FMNNADPH dehydrogenase/0.463
3tjlFMNNADPH dehydrogenase/0.460
1z41FMNNADPH dehydrogenase/0.459
4uthFMNXenobiotic reductase/0.459
1bwsNDPGDP-L-fucose synthase/0.457
4utlFNRXenobiotic reductase/0.456
4h6kFMNNADPH dehydrogenase 11.6.99.10.454
4utkFNRXenobiotic reductase/0.454
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.453
4ycpFMNtRNA-dihydrouridine(16) synthase/0.453
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
3a1nNADNDP-sugar epimerase/0.450
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.450
1oycFMNNADPH dehydrogenase 11.6.99.10.447
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2gouFMNNADH:flavin oxidoreductase Sye1/0.444
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2g8yNADHydroxycarboxylate dehydrogenase B/0.443
4rnxFMNNADPH dehydrogenase 11.6.99.10.443
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.442
4rvfTYDD-mycarose 3-C-methyltransferase/0.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
4zlaBESCytosol aminopeptidase3.4.11.10.441
1d0lBLGMembrane-bound lytic murein transglycosylase B4.2.2.n10.440