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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hr8SAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hr8SAHDiphthine synthase/1.000
2huqSAHDiphthine synthase/0.678
1vceSAHDiphthine synthase/0.677
2e16SAHDiphthine synthase/0.671
2ed5SAHDiphthine synthase/0.669
1wngSAHDiphthine synthase/0.668
2pcaSAHDiphthine synthase/0.666
2owgSAHDiphthine synthase/0.665
2p5fSAHDiphthine synthase/0.665
2owkSAHDiphthine synthase/0.661
2dekSAHDiphthine synthase/0.660
2eglSAHDiphthine synthase/0.660
2dxxSAHDiphthine synthase/0.659
2el0SAHDiphthine synthase/0.657
2egbSAHDiphthine synthase/0.656
2ek3SAHDiphthine synthase/0.655
2huxSAHDiphthine synthase/0.654
2dxvSAHDiphthine synthase/0.653
2eh5SAHDiphthine synthase/0.652
2p9dSAHDiphthine synthase/0.652
2e8qSAHDiphthine synthase/0.651
2ehlSAHDiphthine synthase/0.651
2dxwSAHDiphthine synthase/0.650
2e08SAHDiphthine synthase/0.650
2egsSAHDiphthine synthase/0.649
2eh4SAHDiphthine synthase/0.649
2p5cSAHDiphthine synthase/0.649
2dv7SAHDiphthine synthase/0.646
2p2xSAHDiphthine synthase/0.646
2hutSAHDiphthine synthase/0.645
2eh2SAHDiphthine synthase/0.644
2huvSAHDiphthine synthase/0.644
2e07SAHDiphthine synthase/0.643
2pchSAHDiphthine synthase/0.643
2e8hSAHDiphthine synthase/0.642
2emrSAHDiphthine synthase/0.642
2z6rSAHDiphthine synthase/0.641
2pb4SAHDiphthine synthase/0.640
2owuSAHDiphthine synthase/0.639
2e7rSAHDiphthine synthase/0.638
2ejkSAHDiphthine synthase/0.638
2p6iSAHDiphthine synthase/0.638
2en5SAHDiphthine synthase/0.637
2pcmSAHDiphthine synthase/0.637
2owvSAHDiphthine synthase/0.636
2dshSAHDiphthine synthase/0.635
2eleSAHDiphthine synthase/0.635
2pb5SAHDiphthine synthase/0.634
2eniSAHDiphthine synthase/0.633
2e15SAHDiphthine synthase/0.632
2emuSAHDiphthine synthase/0.632
2dv4SAHDiphthine synthase/0.631
2ejjSAHDiphthine synthase/0.631
2pcgSAHDiphthine synthase/0.628
2el3SAHDiphthine synthase/0.627
2dv5SAHDiphthine synthase/0.626
2e8rSAHDiphthine synthase/0.626
2dv3SAHDiphthine synthase/0.625
2e17SAHDiphthine synthase/0.625
2ek2SAHDiphthine synthase/0.625
2e4nSAHDiphthine synthase/0.624
2ek7SAHDiphthine synthase/0.622
2p6dSAHDiphthine synthase/0.622
2p6kSAHDiphthine synthase/0.622
2e8sSAHDiphthine synthase/0.621
2dsgSAHDiphthine synthase/0.620
2ekaSAHDiphthine synthase/0.619
2dsiSAHDiphthine synthase/0.617
2pckSAHDiphthine synthase/0.617
2ed3SAHDiphthine synthase/0.616
2pb6SAHDiphthine synthase/0.615
2eeqSAHDiphthine synthase/0.612
2ek4SAHDiphthine synthase/0.611
2eldSAHDiphthine synthase/0.611
2p6lSAHDiphthine synthase/0.601
2pciSAHDiphthine synthase/0.595
2owfSAHDiphthine synthase/0.580
2ejzSAHDiphthine synthase/0.556
4g7gVFVLanosterol 14-alpha-demethylase/0.504
1lbcCYZGlutamate receptor 2/0.487
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.484
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.481
4g3jVNTLanosterol 14-alpha-demethylase/0.480
2gjlFMNNitronate monooxygenase1.13.12.160.477
2ifaFMNUncharacterized protein/0.476
3hl0NADMaleylacetate reductase/0.475
1xe55FEPlasmepsin-23.4.23.390.474
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.473
3zh8C58Protein kinase C iota type2.7.11.130.473
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.471
3gw9VNILanosterol 14-alpha-demethylase/0.471
2znnS44Peroxisome proliferator-activated receptor alpha/0.470
2xlrFADPutative flavin-containing monooxygenase/0.469
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.468
4ipw1G7Mycocyclosin synthase1.14.21.90.468
2b53D23Cyclin-dependent kinase 22.7.11.220.467
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.467
3oibFDAPutative acyl-CoA dehydrogenase/0.467
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
1hdrNADDihydropteridine reductase1.5.1.340.466
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.464
4a8v2ANMajor pollen allergen Bet v 1-J/0.463
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.462
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.462
1zeoC01Peroxisome proliferator-activated receptor gamma/0.461
2pswCOAN-alpha-acetyltransferase 50/0.460
2y3sTIRTamL/0.460
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
1x1dSAHC-20 methyltransferase/0.459
2a94AP0L-lactate dehydrogenase1.1.1.270.459
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.459
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.459
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
3ig6438Urokinase-type plasminogen activator3.4.21.730.459
1bxoPP7Penicillopepsin-13.4.23.200.458
1x1cSAHC-20 methyltransferase/0.458
1xddAAYIntegrin alpha-L/0.457
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.457
2q5g1FAPeroxisome proliferator-activated receptor delta/0.457
1f20FADNitric oxide synthase, brain1.14.13.390.456
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.456
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.456
3vqsJT1Genome polyprotein/0.456
3lqfNADGalactitol dehydrogenase/0.455
3mdmFJZCholesterol 24-hydroxylase/0.455
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.455
4irnFADAnaB/0.455
4q71FADBifunctional protein PutA/0.455
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.454
3ixp834Ecdysone receptor/0.454
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.454
1g1aNADdTDP-glucose 4,6-dehydratase/0.453
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4egbNADdTDP-glucose 4,6-dehydratase/0.453
1tqf32PBeta-secretase 13.4.23.460.452
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.452
2p5uNADUDP-glucose 4-epimerase/0.452
2qbuSAHPrecorrin-2 methyltransferase/0.452
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.452
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
1bil0IURenin3.4.23.150.451
1dhrNADDihydropteridine reductase1.5.1.340.451
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.451
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.451
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3lpkZ76Beta-secretase 13.4.23.460.451
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.451
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.451
1g63FMNEpidermin decarboxylase4.1.10.450
2g1r3IGRenin3.4.23.150.450
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.450
2oapANPType II secretion system protein (GspE-2)/0.450
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.450
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.450
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4eb7PLPCysteine desulfurase IscS 2/0.450
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4xguADPPutative pachytene checkpoint protein 2/0.450
4j0v1H7Beta-secretase 13.4.23.460.449
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.448
1pjcNADAlanine dehydrogenase/0.448
1x1aSAMC-20 methyltransferase/0.448
1xl5190Gag-Pol polyprotein3.4.23.160.448
2znpK55Peroxisome proliferator-activated receptor delta/0.448
3a3gDLZLumazine protein/0.448
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.448
4jbiNDPAlcohol dehydrogenase (Zinc)/0.448
4qecNAPElxO/0.448
5af7FADAcyl-CoA dehydrogenase/0.448
1dirNADDihydropteridine reductase1.5.1.340.447
1rneC60Renin3.4.23.150.447
2gmjFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.447
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.447
3f3sNADLambda-crystallin homolog/0.447
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.447
4nbwNADShort-chain dehydrogenase/reductase SDR/0.447
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1bwsNDPGDP-L-fucose synthase/0.446
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.446
2q4bNAPUncharacterized protein At5g02240/0.446
2rhgIGPTryptophan synthase alpha chain/0.446
3tneRITCandidapepsin-13.4.23.240.446
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.446
1vp6CMPCyclic nucleotide-gated potassium channel mll3241/0.445
2wedPP6Penicillopepsin-13.4.23.200.445
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.445
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.444
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.444
3pndFADFAD:protein FMN transferase/0.444
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.444
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
2rcyNAPPyrroline-5-carboxylate reductase/0.443
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443
4dpy2P0Mevalonate diphosphate decarboxylase/0.443
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.443
4ure1PSCyclohexanol dehydrogenase/0.443
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.443
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
1x1bSAHC-20 methyltransferase/0.442
2bjfDXCCholoylglycine hydrolase3.5.1.240.442
2fznFADBifunctional protein PutA1.5.5.20.442
2ien017Gag-Pol polyprotein3.4.23.160.442
3ggoNAIPrephenate dehydrogenase/0.442
3ik6HCZGlutamate receptor 2/0.442
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.442
4yaoFMNNADPH--cytochrome P450 reductase/0.442
5c77SAHProtein arginine N-methyltransferase SFM1/0.442
1ma0NADAlcohol dehydrogenase class-31.1.1.10.441
1w6hTITPlasmepsin-23.4.23.390.441
2iviACWIsopenicillin N synthase1.21.3.10.441
2oegUPGUDP-glucose pyrophosphorylase/0.441
2xhd7T9Glutamate receptor 2/0.441
2xx91NFGlutamate receptor 2/0.441
2zsaADPPantothenate kinase2.7.1.330.441
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3to6LYS_CMCHistone acetyltransferase ESA1/0.441
3uylTYDProbable NDP-rhamnosyltransferase/0.441
4a83DXCMajor pollen allergen Bet v 1-A/0.441
4ambDUDPutative glycosyl transferase/0.441
5hwsNAP2-dehydropantoate 2-reductase/0.441
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.440
1me6IVSPlasmepsin-23.4.23.390.440
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.440
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.440
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.440
4a802ANMajor pollen allergen Bet v 1-A/0.440
4h3j10WBeta-secretase 13.4.23.460.440
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.440
4r20AERCytochrome P450 family 17 polypeptide 2/0.440