Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
2hl1 | A3S | Threonine--tRNA ligase | 6.1.1.3 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
2hl1 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 1.000 | |
4rrq | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.679 | |
3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.613 | |
2hl2 | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.601 | |
3pd5 | TSB | Threonine--tRNA ligase | 6.1.1.3 | 0.601 | |
3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.594 | |
4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.570 | |
3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.562 | |
2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.560 | |
4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.555 | |
4rrm | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.548 | |
4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.546 | |
4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.543 | |
4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.534 | |
4rri | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.534 | |
4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.516 | |
4rrb | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.512 | |
4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.507 | |
4rrd | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.503 | |
4rrc | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.501 | |
4rrl | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.498 | |
3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.495 | |
3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.491 | |
4rr9 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.487 | |
5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.485 | |
4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.484 | |
2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.483 | |
4rrk | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.481 | |
1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.475 | |
1r2j | FAD | FkbI | / | 0.474 | |
3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
5h8t | RTL | Retinol-binding protein 1 | / | 0.470 | |
4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.469 | |
1syn | F89 | Thymidylate synthase | / | 0.468 | |
3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.468 | |
3pgi | F41 | Endothiapepsin | 3.4.23.22 | 0.466 | |
4rrj | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.466 | |
4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.466 | |
3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.465 | |
4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.464 | |
4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.464 | |
4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.463 | |
4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
4lww | LWW | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.463 | |
4m6p | 20R | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.463 | |
3dr1 | C5D | Vitamin D3 receptor A | / | 0.462 | |
3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.462 | |
3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.462 | |
2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.461 | |
3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.460 | |
3u8h | BHP | Phospholipase A2, membrane associated | / | 0.460 | |
4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.460 | |
5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.460 | |
3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.459 | |
3w5p | 4OA | Vitamin D3 receptor | / | 0.459 | |
1fml | RTL | Retinol dehydratase | / | 0.458 | |
3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.458 | |
3v49 | PK0 | Androgen receptor | / | 0.458 | |
4gu6 | 10N | Focal adhesion kinase 1 | 2.7.10.2 | 0.458 | |
1gvv | 0GM | Endothiapepsin | 3.4.23.22 | 0.457 | |
1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.457 | |
4o71 | CPB | Bromodomain-containing protein 4 | / | 0.457 | |
5iub | CLR | Adenosine receptor A2a | / | 0.457 | |
1kqw | RTL | Cellular retinol-binding protein type II | / | 0.456 | |
4lxh | C1E | Alpha/beta hydrolase fold | / | 0.456 | |
4oac | ADP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.456 | |
1od1 | 0QS | Endothiapepsin | 3.4.23.22 | 0.455 | |
1ve3 | SAM | Uncharacterized protein | / | 0.455 | |
3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.455 | |
3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.455 | |
4ma6 | 28E | Ara h 8 allergen | / | 0.455 | |
4nmb | FAD | Bifunctional protein PutA | / | 0.455 | |
1fmj | RTL | Retinol dehydratase | / | 0.454 | |
1q4x | G24 | Thyroid hormone receptor beta | / | 0.454 | |
2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.454 | |
2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.454 | |
3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.453 | |
2g1p | SAH | DNA adenine methylase | 2.1.1.72 | 0.453 | |
2z3u | CRR | Cytochrome P450 | / | 0.453 | |
3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.453 | |
4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.453 | |
1d2s | DHT | Sex hormone-binding globulin | / | 0.452 | |
3gwf | FAD | Cyclohexanone monooxygenase | / | 0.452 | |
4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.452 | |
4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.451 | |
4ite | TEY | Vitamin D3 receptor | / | 0.451 | |
4lm5 | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.450 | |
1hk1 | T44 | Serum albumin | / | 0.450 | |
1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.450 | |
2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.450 | |
4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.450 | |
4pkl | 1GH | Uncharacterized protein | / | 0.450 | |
3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.450 | |
1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.449 | |
2gpu | OHT | Estrogen-related receptor gamma | / | 0.449 | |
3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
3ggg | NAD | Prephenate dehydrogenase | / | 0.449 | |
3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.449 | |
4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.449 | |
4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.449 | |
1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
2jjj | 0QS | Endothiapepsin | 3.4.23.22 | 0.448 | |
2k62 | ITL | Fatty acid-binding protein, liver | / | 0.448 | |
2w3w | VG9 | Dihydrofolate reductase | / | 0.448 | |
3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
3oqk | S52 | Renin | 3.4.23.15 | 0.448 | |
4a9i | P9I | Bromodomain-containing protein 2 | / | 0.448 | |
4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.448 | |
5iu8 | 6DZ | Adenosine receptor A2a | / | 0.448 | |
1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
3q5k | D1U | Heat shock protein 83-1 | / | 0.447 | |
4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
4kfn | 1QR | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.447 | |
3eml | ZMA | Adenosine receptor A2a | / | 0.447 | |
1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.446 | |
2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
3w5t | LHP | Vitamin D3 receptor | / | 0.446 | |
4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.446 | |
1tsd | F89 | Thymidylate synthase | / | 0.445 | |
2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.445 | |
2has | C3O | Vitamin D3 receptor | / | 0.445 | |
2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.445 | |
2p7z | OHT | Estrogen-related receptor gamma | / | 0.445 | |
2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
3vf8 | 0JE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.445 | |
4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
5jtb | ZMA | Adenosine receptor A2a | / | 0.445 | |
1byg | STU | Tyrosine-protein kinase CSK | / | 0.444 | |
1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.444 | |
2ewp | TXF | Estrogen-related receptor gamma | / | 0.444 | |
2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.444 | |
3ix8 | TX3 | Transcriptional activator protein LasR | / | 0.444 | |
4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.444 | |
4kfp | 1R7 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.444 | |
4lts | LTS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.444 | |
4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.444 | |
4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
4xwt | U5P | Ribonuclease J | / | 0.444 | |
5eyp | LOC | Tubulin beta chain | / | 0.444 | |
1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
1nde | MON | Estrogen receptor beta | / | 0.443 | |
1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
1xp6 | AIU | Estrogen receptor | / | 0.443 | |
2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.443 | |
2ham | C33 | Vitamin D3 receptor | / | 0.443 | |
3q9w | EMO | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.443 | |
4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
4q0a | 4OA | Vitamin D3 receptor A | / | 0.443 | |
4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.443 | |
1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.442 | |
1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.442 | |
1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.442 | |
2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.442 | |
2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.442 | |
3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
3t2k | FAD | Sulfide-quinone reductase | / | 0.442 | |
3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
3vt8 | YI3 | Vitamin D3 receptor | / | 0.442 | |
3w0y | DS4 | Vitamin D3 receptor | / | 0.442 | |
3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
1ddt | APU | Diphtheria toxin | / | 0.441 | |
1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
1u54 | ACP | Activated CDC42 kinase 1 | / | 0.441 | |
1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.441 | |
2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.441 | |
2fum | MIX | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.441 | |
2vn9 | GVD | Calcium/calmodulin-dependent protein kinase type II subunit delta | 2.7.11.17 | 0.441 | |
3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
3r35 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
3vru | YS3 | Vitamin D3 receptor | / | 0.441 | |
3w0a | DS5 | Vitamin D3 receptor | / | 0.441 | |
3w0h | W12 | Vitamin D3 receptor | / | 0.441 | |
4aoj | V4Z | High affinity nerve growth factor receptor | 2.7.10.1 | 0.441 | |
4hnc | 0UT | Mandelate racemase | / | 0.441 | |
4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
4r81 | FMN | Predicted NADH dehydrogenase | / | 0.441 | |
4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
5iua | 6DX | Adenosine receptor A2a | / | 0.441 | |
1bws | NDP | GDP-L-fucose synthase | / | 0.440 | |
1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
1kzi | THG | Thymidylate synthase | / | 0.440 | |
2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
2imf | TOM | 2-hydroxychromene-2-carboxylate isomerase | 5.99.1.4 | 0.440 | |
2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.440 | |
2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.440 | |
2xyt | TC9 | Soluble acetylcholine receptor | / | 0.440 | |
3dcv | 55E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
3vew | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.440 | |
4fhh | 0U3 | Vitamin D3 receptor A | / | 0.440 | |
4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.440 | |
4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 |