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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hejNDPAldo-keto reductase family 1 member C211.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hejNDPAldo-keto reductase family 1 member C211.1.11.000
2p5nNDPAldo-keto reductase family 1 member C211.1.10.598
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.535
4jtqNAPAldo-keto reductase family 1 member C2/0.531
4xo7NAPAldo-keto reductase family 1 member C2/0.520
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.507
2hdjNDPAldo-keto reductase family 1 member C2/0.505
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.502
4dz5NAPAldo-keto reductase family 1 member C3/0.502
1s1rNAPAldo-keto reductase family 1 member C3/0.494
3h7rNAPAldo-keto reductase family 4 member C8/0.488
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.486
2iq0NAPAldose reductase1.1.1.210.475
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.474
3q65NAPAldose reductase1.1.1.210.473
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.473
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.471
2j8tNAPAldose reductase1.1.1.210.470
4jq3NAPAldo-keto reductase family 1 member C2/0.469
1x96NAPAldose reductase1.1.1.210.467
2acqNAPAldose reductase1.1.1.210.467
1ah4NAPAldose reductase1.1.1.210.466
1az2NAPAldose reductase1.1.1.210.465
1x98NAPAldose reductase1.1.1.210.463
4l1xNAPAldo-keto reductase family 1 member C2/0.456
2pf8NDPAldose reductase1.1.1.210.452
4pmjNAPPutative oxidoreductase/0.452
2pevNDPAldose reductase1.1.1.210.449
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.449
3wczNAPAldo-keto reductase AKR2E4/0.449
1z8aNAPAldose reductase1.1.1.210.448
1c9wNAPAldose reductase-related protein 2/0.442
3q67NAPAldose reductase1.1.1.210.442
1zgdNAPChalcone reductase/0.440
2he5NDPAldo-keto reductase family 1 member C211.1.10.440
2pfhNDPAldose reductase1.1.1.210.440