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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/1.000
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.539
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.532
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.527
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.473
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.464
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.463
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.458
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.454
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.453
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.448
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440