sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 1.000 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.554 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.531 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.497 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.475 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.456 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.453 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 3wcz | NAP | Aldo-keto reductase AKR2E4 | / | 0.450 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.449 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.449 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.448 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.448 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.446 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.446 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.445 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.443 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.443 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.443 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.443 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.443 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.442 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 3mzt | TFX | Beta-2-microglobulin | / | 0.442 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.441 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.441 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.440 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.440 | |
| 5dp2 | NAP | CurF | / | 0.440 |